Frontiers in Gastroenterology · Published 2026-07-15 · DOI 10.3389/fgstr.2026.1832175
Qiannan Wang, Kinan Drak Alsibai, Sarah Bailly, Jean-Pierre Droz, Dominique Louvel, Mathieu Nacher, Alolia Aboikoni
BackgroundHelicobacter pylori infection is a major etiological factor for gastric cancer, but its prognostic relevance once invasive gastric cancer has developed remains uncertain in French Guiana.MethodsWe conducted a retrospective hospital-based study including all patients diagnosed with histologically confirmed invasive gastric carcinoma at Cayenne Hospital Center between 2018 and 2023. H. pylori status was assessed by routine histopathology. Sociodemographic, clinicopathological, and histological characteristics, including associated gastric lesions, were collected. Overall survival was estimated using the Kaplan–Meier method and compared using the log-rank test according to H. pylori status and initial management strategy. Exploratory multivariable Cox regression analyses were performed.ResultsEighty-two patients were included, of whom 43 (52.4%) were H. pylori-positive. H. pylori positivity was significantly associated with non-active chronic gastritis, whereas H. pylori detection was uncommon in active chronic gastritis. H. pylori status was not associated with tumor location, histological subtype, differentiation, or preneoplastic lesions. Median follow-up was 25.7 months. Overall survival did not differ between H. pylori-positive and H. pylori-negative patients. In multivariable analyses, H. pylori status was not associated with survival, whereas initial management was strongly associated with outcome, likely reflecting disease stage at diagnosis rather than a causal treatment effect.ConclusionRoutine histology detected H. pylori in about half of gastric tumors, with an association with non-active chronic gastritis. H. pylori status was not associated with survival; differences by initial management likely reflected disease severity, with interpretation limited by incomplete TNM staging.
Abstract from DOAJ. Public domain (CC0 1.0).
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Wang, Q., Alsibai, K., Bailly, S., et al. (2026). Helicobacter pylori infection in gastric cancer patients in French Guiana: a hospital-based study (2018–2023). Frontiers in Gastroenterology. https://doi.org/10.3389/fgstr.2026.1832175