Current Directions in Biomedical Engineering · Published 2025-09-01 · DOI 10.1515/cdbme-2025-0206
Blood gas analyses (BGAs) are used during mechanical ventilation as a diagnostic tool for partial pressures of gases in the blood, but deliver only spot measurements due to their invasive nature. We evaluate an established neonatal pulmonary model on its suitability to estimate partial pressures of oxygen and carbon dioxide to bridge the gap between BGAs. The evaluation is twofold. First, we conduct a comparison to the model’s original evaluation, using five patients with one simulation each, to underline the importance of reproducibility of implementations. Second, we perform an evaluation based on a collected dataset of 11 patients and 452 simulations, comparing the simulated partial pressures of O2 and CO2 to BGA measurements. We report considerable deviations from real measurements and propose adaptations to improve the simulation.
Abstract from DOAJ. Public domain (CC0 1.0).
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