International Journal of Gastrointestinal Intervention · Published 2026-04-28 · DOI 10.18528/ijgii260011
Polypoid lesions at colorectal endoscopic submucosal dissection (ESD) scars are often interpreted as local tumor recurrence, although benign scar-related changes, such as polypoid nodule scar (PNS), have been reported in the colorectum in rare cases. We report the case of a 66-year-old man who developed recurrent polypoid lesions at a sigmoid colon ESD scar after curative resection of an intramucosal adenocarcinoma. Despite repeated endoscopic treatment, the lesions recurred; however, histopathologic examination consistently demonstrated granulation tissue with regenerative epithelial hyperplasia and no dysplasia or malignancy. Subsequent surveillance colonoscopies showed spontaneous resolution, with no recurrence during long-term follow-up. This case highlights the importance of recognizing benign PNS lesions to avoid unnecessary aggressive endoscopic or surgical intervention.
Abstract from DOAJ. Public domain (CC0 1.0).
Read the article at the publisher →