Copper depletion boosts CNS leukemia therapy by inhibiting nucleotide synthesis through impairment of mitochondrial complex IV activity

Nature Cancer · Published 2026-05-25 · DOI 10.1038/s43018-026-01177-4

Authors (21)

Alan Y. L. Wong, Jacob W. Myers, Gyan Prakash, Alice Ma, Jeannette R. Brook, Boryana Petrova, Baran Bulut, Ralph White, Catherine Merz, Maeve de Souza, Adam G. Maynard, Peng Wang, Amy Yu, Nancy K. Pohl, Michal Weitman, Lewis B. Silverman, Kimberly Stegmaier, L. Stirling Churchman, Peter D. Cole, Donita C. Brady, Naama Kanarek

Abstract

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Publication details

Year
2026

Citation

Wong, A., Myers, J., Prakash, G., et al. (2026). Copper depletion boosts CNS leukemia therapy by inhibiting nucleotide synthesis through impairment of mitochondrial complex IV activity. Nature Cancer. https://doi.org/10.1038/s43018-026-01177-4

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