Medical Mycology Case Reports · Published 2026-01-20 · DOI 10.1016/j.mmcr.2026.100762
We report a 41-year-old woman with systemic lupus erythematosus who developed cryptococcal meningitis five months after a second rituximab cycle. Initial symptoms mimicked an SLE flare, delaying diagnosis. Worsening neurologic deficits prompted lumbar puncture, revealing findings consistent with fungal meningitis and CSF culture positive for Cryptococcus neoformans. Treatment with amphotericin B and fluconazole resulted in clinical improvement, highlighting the diagnostic challenges and the need for early evaluation in immunosuppressed SLE patients.
Abstract from DOAJ. Public domain (CC0 1.0).
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