Annals of Internal Medicine: Clinical Cases · Published 2026-06-01 · DOI 10.7326/aimcc.2025.1408
Samantha L. Shapiro, Haley Probst, David A. Feldstein
Diabetic myonecrosis (also known as diabetic muscle infarction, or DMI) is a rare complication of poorly controlled diabetes, with fewer than 200 discrete cases reported in the English language medical literature over the past 60 years. In most published cases, diabetic myonecrosis occurs concurrently with other micro/macrovascular diabetic sequelae (e.g., nephropathy). Here, we describe a case of a patient with DMI without nephropathy, whose presentation was otherwise pathognomonic for DMI. We share this case to increase clinician awareness of this uncommon condition and to highlight the diagnostic and treatment considerations to keep in mind when managing suspected DMI, as choice of treatment can dramatically affect clinical course.
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Shapiro, S., Probst, H., Feldstein, D. (2026). Acute Thigh Pain in a Patient With Diabetes Mellitus: A Rare Case of Diabetic Myonecrosis. Annals of Internal Medicine: Clinical Cases. https://doi.org/10.7326/aimcc.2025.1408