Annals of Internal Medicine: Clinical Cases · Published 2026-07-01 · DOI 10.7326/aimcc.2025.1285
Daniel Weis, Philippe Braconnier, Claude Schalbar
Chronic lymphocytic leukemia (CLL) rarely causes clinically significant renal involvement, particularly in early-stage disease. We report a patient with Binet stage A CLL who developed progressive renal dysfunction due to probable diffuse leukemic infiltration of the kidneys. Diagnostic evaluation included blood studies, urinalysis, and ultimately kidney biopsy confirming dense interstitial accumulation of CD20−/CD23+ B cells. Ibrutinib therapy was well tolerated but kidney function did not recover. This case highlights that even low-stage CLL may present with organ infiltration and that unexplained renal impairment warrants early consideration of leukemic involvement.
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Weis, D., Braconnier, P., Schalbar, C. (2026). Terminal Kidney Failure in a Patient With Renal Involvement of Chronic Lymphocytic Leukemia. Annals of Internal Medicine: Clinical Cases. https://doi.org/10.7326/aimcc.2025.1285