Changing Research Orientations in Paget’s Disease of Bone: A Bibliometric Analysis

Inquiry: The Journal of Health Care Organization, Provision, and Financing · Published 2026-03-01 · DOI 10.1177/00469580261469861

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Abstract

Introduction Paget’s disease of bone (PDB) has long been studied as a condition characterized by disordered bone remodeling. In recent decades, research has increasingly incorporated molecular, genetic, and systemic perspectives, reflecting a broader understanding of the disease. Despite this apparent expansion, changes in the overall research orientation of the PDB field have not been systematically assessed at the field level. Methods A bibliometric analysis was performed using PDB-related publications indexed in the Web of Science Core Collection between 1999 and 2025. Publication trends, keyword-based thematic mapping, temporal patterns, and citation indicators were analyzed to examine shifts in research focus. Studies were categorized into three research orientations. These included bone-centered studies, molecular and genetic studies, and systemic and neurological studies. The evolution of these orientations over time was evaluated using descriptive metrics. Results A total of 963 articles published between 1999 and 2025 were included. The Systemic Orientation Index showed a sustained upward trajectory, indicating a gradual shift of PDB research beyond a predominantly bone-centered framework. In time-adjusted citation analysis, systemic and neurological studies showed the highest mean citations per year at 2.63, compared with 1.46 for both bone-centered and molecular and genetic studies. Conclusions The findings demonstrate a progressive broadening of PDB research beyond a predominantly skeletal framework. While bone-centered studies continue to form the foundation of the field, molecular, genetic, and systemic approaches are playing an important role in shaping contemporary research on PDB.

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Year
2026

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