Russian Open Medical Journal · Published 2025-09-30 · DOI 10.15275/rusomj.2025.0312
The authors conducted a retrospective analysis of international publications devoted to the effects of endogenous and exogenous factors on the circadian rhythms of circulating blood cells. More than thirty studies were analyzed. No unequivocal conclusion regarding the 24‑hour dynamics of blood cell parameters was reached. These parameters showed substantial interindividual variability, especially against the background of sleep deprivation. In addition, the absence of a standardized approach to the quantitative assessment of circadian rhythms considerably complicates cross-study comparisons. Nevertheless, most authors agree that total or partial sleep deprivation results in circadian misalignment (desynchronosis), including disturbances in blood cell regulation. Circadian dynamics of blood parameters need further investigation, particularly within a personalized framework. The emphasis on developing wearable devices for prolonged monitoring should be put. Researchers should also aim to standardize study designs and to investigate post-illness alterations in circadian rhythms of blood parameters.
Abstract from DOAJ. Public domain (CC0 1.0).
Read the article at the publisher →