Child's Health · Published 2026-05-30 · DOI 10.22141/2224-0551.21.3.2026.1957
M.N.A. Apriansah, Sunny Mariana Samosir, Riza Noviandi, Prastiya Indra Gunawan
Background. Epilepsy in early childhood can cause a significant developmental and psychosocial burden, yet the determinants of health-related quality of life (HRQoL) in patients aged 2–4 years remain inadequately characterized, especially in clinical settings. This limited evidence becomes a hindrance to holistic management strategies for children with epilepsy. The purpose was to analyze factors that influence the quality of life of children with epilepsy, especially those aged 2–4 years. Materials and methods. A cross-sectional study was conducted involving 101 participants recruited from a pediatric neurology clinic. Questionnaire-based interviews using the PedsQL Epilepsy Module were performed to assess the HRQoL. Bivariate and multivariate analyses were used to assess factors associated with quality of life. Results. The highest proportion with poor HRQoL was observed in cognitive (67.3 %) and executive (73.3 %) domains. In multivariable analysis, seizure frequency ≥ 2 times per month (OR = 3.562; p = 0.026) and treatment duration ≥ 1 year (OR = 3.862; p = 0.006) were independently associated with poor HRQoL. Conclusions. The findings of this study highlight the importance of early detection of children with epilepsy who are at risk of reduced HRQoL, enabling more targeted interventions that extend beyond a sole focus on clinical improvement.
Abstract from DOAJ. Public domain (CC0 1.0).
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Apriansah, M., Samosir, S., Noviandi, R., et al. (2026). Factors influencing the quality of life of children with epilepsy aged 2–4 years. Child's Health. https://doi.org/10.22141/2224-0551.21.3.2026.1957