Journal of Pharmacy & Pharmacognosy Research · Published 2026-03-01 · DOI 10.56499/jppres_14.2.2513
Context: Alopecia affects a large population and current treatments have limited efficacy and tolerability. Essential oils have gained increasing interest as natural, low-risk alternatives. Aims: To evaluate the effects of Syzygium aromaticum and Rosmarinus officinalis oils, alone and in combination, on hair regrowth in rats and compared with 2% minoxidil. Methods: S. aromaticum oil was prepared by hydro-distillation, while R. officinalis oil was purchased from the local market and analysed by GCMS. Male Wistar rats (n=30) were randomized to negative control (vehicle), 2% minoxidil, S. aromaticum oil, R. officinalis oil, and a S. aromaticum-R. officinalis oil mixture groups. Treatments were applied topically on a shaved dorsal skin area once a day for 35 days. The times required for hair growth initiation and completion were recorded, along with hair growth scores on days 7, 21, and 35. On day 35, hair weight, length, and thickness were measured, and skin histology was examined. Results: All active treatments showed significant improvements in hair regrowth parameters manifested by a significant reduction in the duration of hair initiation and completion and improvement in all the measured parameters. The effects of S. aromaticum oil and R. officinalis oil on hair re-growth were comparable to that of minoxidil. The oils mixture demonstrated superior performance to minoxidil in terms of faster regrowth initiation (6.5 days), completion (21.83 days), and higher hair weight (22.2 mg/cm²) and length (16.67 mm). Histology indicated a higher follicle density in treated groups. Conclusions: The oils mixture exhibited an additive effect, outperforming minoxidil in promoting hair regrowth.
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