Research map: GAPDH inhibition by oridonin integrates glycolytic inhibition and anti-inflammation to alleviate rheumatoid arthritis synovitis

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  1. Fibroblast‐like synoviocytes: key effector cells in rheumatoid arthritis · Beatrix Bartók · 2009 · 1947 citations · Cited by this paper
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  13. Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albumin. · Theodore W. C. Lo · 1994 · 699 citations · Cited by this paper
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  19. Signaling pathways in rheumatoid arthritis: implications for targeted therapy · Qian Ding · 2023 · 477 citations · Cited by this paper
  20. 4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects · Shanting Liao · 2019 · 469 citations · Cited by this paper
  21. Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites. · Wilhelm Krek · 1991 · 448 citations · Cited by this paper
  22. Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis · Marta F. Bustamante · 2017 · 426 citations · Cited by this paper
  23. A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling · Michael J. Bollong · 2018 · 356 citations · Cited by this paper
  24. Experimental animal models for rheumatoid arthritis · Narayan Choudhary · 2018 · 304 citations · Cited by this paper
  25. Structure of holo-glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus at 1.8 Å resolution · T. Skarżński · 1987 · 276 citations · Cited by this paper
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  28. The Chaperone-Dependent Ubiquitin Ligase CHIP Targets HIF-1α for Degradation in the Presence of Methylglyoxal · Carla F. Bento · 2010 · 134 citations · Cited by this paper
  29. Glycoxidation of biological macromolecules: A critical approach to halt the menace of glycation · Saheem Ahmad · 2014 · 130 citations · Cited by this paper
  30. Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance · Xi Liu · 2020 · 129 citations · Cited by this paper
  31. Novel Nitrogen-Enriched Oridonin Analogues with Thiazole-Fused A-Ring: Protecting Group-Free Synthesis, Enhanced Anticancer Profile, and Improved Aqueous Solubility · Chunyong Ding · 2013 · 112 citations · Cited by this paper
  32. Cellular metabolic adaptations in rheumatoid arthritis and their therapeutic implications · Ursula Fearon · 2022 · 103 citations · Cited by this paper
  33. Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1 · Craig M. Forester · 2007 · 95 citations · Cited by this paper
  34. Methylglyoxal in Metabolic Disorders: Facts, Myths, and Promises · Paulo N. Matafome · 2016 · 92 citations · Cited by this paper
  35. Blood chemokine profile in untreated early rheumatoid arthritis: CXCL10 as a disease activity marker · Jayesh M. Pandya · 2017 · 91 citations · Cited by this paper
  36. PrfA regulation offsets the cost of L isteria virulence outside the host · Radhakrishnan B. Vasanthakrishnan · 2015 · 69 citations · Cited by this paper
  37. Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types · Sadiq Umar · 2021 · 66 citations · Cited by this paper
  38. Role of glucose metabolism in aggressive phenotype of fibroblast-like synoviocytes: Latest evidence and therapeutic approaches in rheumatoid arthritis · Maryam Masoumi · 2020 · 62 citations · Cited by this paper
  39. Difficult-to-treat rheumatoid arthritis: what have we learned and what do we still need to learn? · Zonne L. M. Hofman · 2024 · 56 citations · Cited by this paper

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