Research map: In vitro and in vivo intestinal and hepatic oxidative metabolism of typical cytochrome P450 3A substrates, midazolam, nifedipine, and quinidine, in minipigs: A comparison with humans, monkeys, and dogs

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  1. Physiological Parameters in Laboratory Animals and Humans · Brian E. Davies · 1993 · 2935 citations · Cited by this paper
  2. Genetic polymorphisms of drug-metabolizing cytochromes P450 and flavin-containing monooxygenases in dogs and pigs inform the prediction of drug metabolism and toxicity in humans and other animal species · Yasuhiro Uno · 2026 · Cites this paper
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  6. Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals · Tugrul T. Kararli · 1995 · 1468 citations · Cited by this paper
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  8. Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes · Ronald Scott Obach · 1999 · 1231 citations · Cited by this paper
  9. Behavioural toxicodynamics and kinetic profiling of PCB congeners in Swiss Albino mouse dosed with Aroclor 1232 through inhalational route: a pivotal risk assessment study · 2026 · Related
  10. Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. · Frederick Peter Guengerich · 1986 · 730 citations · Cited by this paper
  11. The protective effect of linalool against carbon tetrachloride-induced testicular toxicity in rats · 2026 · Related
  12. The utility of the minipig as an animal model in regulatory toxicology · Gerd Bode · 2010 · 402 citations · Cited by this paper
  13. Steady-state pharmacokinetics of oral semaglutide using semi-mechanistic pharmacokinetic modelling and population simulations · 2026 · Related
  14. Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination · Manthena V. S. Varma · 2010 · 337 citations · Cited by this paper
  15. Linalool, linalyl acetate, and lavender essential oil: evaluation of metabolism and drug interactions using canine liver microsomes and recombinant enzymes · 2026 · Related
  16. Prediction of Human Intestinal First-Pass Metabolism of 25 CYP3A Substrates from In Vitro Clearance and Permeability Data · Michael Gertz · 2010 · 300 citations · Cited by this paper
  17. Novel cytochrome P450 2J isoforms in tree shrews are functional drug-metabolising enzymes involved in ebastine and astemizole oxidation · 2026 · Related
  18. Linear Correlation of the Fraction of Oral Dose Absorbed of 64 Drugs Between Humans and Rats · Win Loung Chiou · 1998 · 260 citations · Cited by this paper
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  20. Animal versus human oral drug bioavailability: Do they correlate? · Helen Musther · 2013 · 212 citations · Cited by this paper
  21. SUBSTRATE DEPLETION APPROACH FOR DETERMINING IN VITRO METABOLIC CLEARANCE: TIME DEPENDENCIES IN HEPATOCYTE AND MICROSOMAL INCUBATIONS · Hannah M. Jones · 2004 · 186 citations · Cited by this paper
  22. Evaluation of Using Dog as an Animal Model to Study the Fraction of Oral Dose Absorbed of 43 Drugs in Humans · Win Loung Chiou · 2000 · 183 citations · Cited by this paper
  23. Integration of in Vitro Data into Allometric Scaling to Predict Hepatic Metabolic Clearance in Man: Application to 10 Extensively Metabolized Drugs · T. Lave · 1997 · 183 citations · Cited by this paper
  24. Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil · Timothy S. Tracy · 1999 · 181 citations · Cited by this paper
  25. Comparisons of phase I and phase II in vitro hepatic enzyme activities of human, dog, rhesus monkey, and cynomolgus monkey. · Jane E. Sharer · 1995 · 168 citations · Cited by this paper
  26. The minipig in toxicology · Ove Svendsen · 2006 · 158 citations · Cited by this paper
  27. Intestinal and Hepatic Metabolic Activity of Five Cytochrome P450 Enzymes: Impact on Prediction of First-Pass Metabolism · Aleksandra Galetin · 2006 · 156 citations · Cited by this paper
  28. A Comparison of Pharmacokinetics between Humans and Monkeys · Takafumi Akabane · 2009 · 97 citations · Cited by this paper
  29. The pig as a preclinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review · Laura J. Henze · 2018 · 97 citations · Cited by this paper
  30. A Physiologically Based Pharmacokinetic Model of the Minipig: Data Compilation and Model Implementation · Claudia Suenderhauf · 2012 · 93 citations · Cited by this paper
  31. Species Differences in In Vitro and In Vivo Small Intestinal Metabolism of CYP3A Substrates · Hiroshi Komura · 2007 · 88 citations · Cited by this paper
  32. In Vitro Metabolism of Quinidine: The (3 S)-3-Hydroxylation of Quinidine Is a Specific Marker Reaction for Cytochrome P-4503A4 Activity in Human Liver Microsomes · Torben Leo Nielsen · 1999 · 86 citations · Cited by this paper
  33. Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update · Slobodan Rendić · 2021 · 85 citations · Cited by this paper
  34. Prediction of human blood‐to‐plasma drug concentration ratio · Takahide Uchimura · 2010 · 84 citations · Cited by this paper
  35. Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes · Yasuhiro Uno · 2016 · 81 citations · Cited by this paper
  36. Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research: Preface · Naoki Kaneko · 2011 · 78 citations · Cited by this paper
  37. Midazolam α‐Hydroxylation by Human Liver Microsomesin vitro: Inhibition by Calcium Channel Blockers, Itraconazole and Ketoconazole · Jun‐Sheng Wang · 1999 · 71 citations · Cited by this paper
  38. Species Differences in Distribution and Prediction of Human Vss from Preclinical Data · Loren Berry · 2011 · 68 citations · Cited by this paper
  39. Characterization of cynomolgus monkey cytochrome P450 (CYP) cDNAs: Is CYP2C76 the only monkey-specific CYP gene responsible for species differences in drug metabolism? · Yasuhiro Uno · 2007 · 66 citations · Cited by this paper

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