Research map: Optimization strategies for monoclonal antibody production: advances in simulation and artificial intelligence in bioprocessing

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Papers in this map

  1. Principal component analysis · Hervé Abdi · 2010 · 10949 citations · Cited by this paper
  2. Data-Driven Approach for Bioreactor Monitoring and Prediction in Monoclonal Antibody Production · Kadeejathul Kubra · 2026 · Cites this paper
  3. NAStructuralDB : structural database to facilitate computational studies of molecular modeling and recognition of proteins with special focus on antibody–antigen interactions · 2026 · Related
  4. PLS-regression: a basic tool of chemometrics · Svante Wold · 2001 · 10036 citations · Cited by this paper
  5. Engineering of acidic pH-responsive anti-CD3 binding antibodies · 2026 · Related
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  7. Structure-based calculation of excipient effects on the viscosity of concentrated antibody solutions · 2026 · Related
  8. Artificial Intelligence in Pharmaceutical Technology and Drug Delivery Design · Lalitkumar K. Vora · 2023 · 1049 citations · Cited by this paper
  9. Balancing the extremes for antibody developability: hydrophobic and electrostatic germline framework signatures for CDR-loop compensation · 2026 · Related
  10. Review of multidimensional data processing approaches for Raman and infrared spectroscopy · Rekha Gautam · 2015 · 698 citations · Cited by this paper
  11. Efficient inference of non-polyreactive antibody variants dependent on local fine-tuning · 2026 · Related
  12. Industrialization of mAb production technology: The bioprocessing industry at a crossroads · Brian D. Kelley · 2009 · 672 citations · Cited by this paper
  13. ASD: antigen-specific antibody database · 2026 · Related
  14. Artificial intelligence and machine learning in clinical development: a translational perspective · Pratik P. Shah · 2019 · 520 citations · Cited by this paper
  15. Expanding the horizons of cancer therapy with next-generation 4-1BB agonists: a review of molecular and clinical strategies to maximize efficacy and ensure safety · 2026 · Related
  16. Bioseparations Science and Engineering · Roger G. Harrison · 2015 · 408 citations · Cited by this paper
  17. AbDist: a lightweight, distance-based model for antibody affinity prediction as an interpretable benchmark for machine learning models · 2026 · Related
  18. White Paper on Continuous Bioprocessing May 20–21 2014 Continuous Manufacturing Symposium · Konstantin B. Konstantinov · 2014 · 347 citations · Cited by this paper
  19. Novel bispecific T-cell engagers overcoming acquired EGFR resistance · 2026 · Related
  20. Sustainable packaging for supply chain management in the circular economy: A review · Lavanya Meherishi · 2019 · 339 citations · Cited by this paper
  21. Protein language models enable prediction of polyreactivity of monospecific, bispecific, and heavy-chain-only antibodies · 2024 · Related
  22. Trends in Upstream and Downstream Process Development for Antibody Manufacturing · Petra Gronemeyer · 2014 · 338 citations · Cited by this paper
  23. Continuous downstream processing of biopharmaceuticals · Alois Jungbauer · 2013 · 329 citations · Cited by this paper
  24. Continuous downstream processing for high value biological products: A Review · Andrew L. Zydney · 2015 · 308 citations · Cited by this paper
  25. The Convergence of Digital Twin, IoT, and Machine Learning: Transforming Data into Action · Maninder Kaur · 2019 · 257 citations · Cited by this paper
  26. The business impact of an integrated continuous biomanufacturing platform for recombinant protein production · Jason Walther · 2015 · 238 citations · Cited by this paper
  27. Predicting Antibody Developability Profiles Through Early Stage Discovery Screening · Marc Andre Bailly · 2020 · 235 citations · Cited by this paper
  28. Biopharmaceuticals from microorganisms: from production to purification · Ângela Faustino Jozala · 2016 · 206 citations · Cited by this paper
  29. Techno-economic analysis of a transient plant-based platform for monoclonal antibody production · Somen Nandi · 2016 · 194 citations · Cited by this paper
  30. Integrated continuous bioprocessing: Economic, operational, and environmental feasibility for clinical and commercial antibody manufacture · James Pollock · 2017 · 188 citations · Cited by this paper
  31. Bioreactor productivity and media cost comparison for different intensified cell culture processes · Sen Xu · 2016 · 171 citations · Cited by this paper
  32. Very-large-scale production of antibodies in plants: The biologization of manufacturing · Johannes F. Buyel · 2017 · 171 citations · Cited by this paper
  33. Data science tools and applications on the way to Pharma 4.0 · Valentin Steinwandter · 2019 · 161 citations · Cited by this paper
  34. Machine Learning for Biologics: Opportunities for Protein Engineering, Developability, and Formulation · Harini Narayanan · 2021 · 160 citations · Cited by this paper
  35. Artificial intelligence and machine learning applications in biopharmaceutical manufacturing · Anurag Singh Rathore · 2022 · 157 citations · Cited by this paper
  36. Economics of recombinant antibody production processes at various scales: Industry‐standard compared to continuous precipitation · Nikolaus Hammerschmidt · 2014 · 135 citations · Cited by this paper
  37. Implementation of Fully Integrated Continuous Antibody Processing: Effects on Productivity and COGm · Lindsay Arnold · 2018 · 135 citations · Cited by this paper
  38. A new, integrated, continuous purification process template for monoclonal antibodies: Process modeling and cost of goods studies · Alex Xenopoulos · 2015 · 126 citations · Cited by this paper
  39. Challenges and opportunities in biopharmaceutical manufacturing control · Moo Sun Hong · 2017 · 125 citations · Cited by this paper

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