Research map: Aortic valve stenosis in 2026: from emerging mechanisms to clinical drug development

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Papers in this map

  1. Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia · Deepak L. Bhatt · 2018 · 3331 citations · Cited by this paper
  2. Persistent gaps in management and risk factor control among patients with atherosclerotic cardiovascular disease: All of us research program · 2026 · Related
  3. Lipoprotein(a) Reduction in Persons with Cardiovascular Disease · Sotirios Tsimikas · 2020 · 1081 citations · Cited by this paper
  4. Standard modifiable cardiovascular risk factors and acute coronary syndrome free survival · 2026 · Related
  5. Genetic Associations with Valvular Calcification and Aortic Stenosis · George Thanassoulis · 2013 · 1014 citations · Cited by this paper
  6. Lipid profile in pediatric and adult patients with lysosomal acid lipase deficiency treated with sebelipase alfa: longitudinal evidence from the International LAL-D Registry · 2026 · Related
  7. Elevated Lipoprotein(a) and Risk of Aortic Valve Stenosis in the General Population · Pia R. Kamstrup · 2013 · 602 citations · Cited by this paper
  8. CD146 extracellular vesicles accumulate at atherosclerotic lesions, reducing inflammation and atheroma burden · 2026 · Related
  9. Impact of Statins on Serial Coronary Calcification During Atheroma Progression and Regression · Rishi Kumar Puri · 2015 · 570 citations · Cited by this paper
  10. NOD1 ligand FK565 promotes atherogenesis and accumulation of NOD1+ smooth muscle cells in atherosclerotic lesions · 2026 · Related
  11. Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990–2017 · Simon Yadgir · 2020 · 493 citations · Cited by this paper
  12. Precision and network medicine in cardiovascular prevention and disease · 2026 · Related
  13. TET2 -Driven Clonal Hematopoiesis and Response to Canakinumab · E. C. Svensson · 2022 · 389 citations · Cited by this paper
  14. Dietary vitamin K intakes and atherosclerotic cardiovascular disease incidence: Findings from the UK biobank · 2026 · Related
  15. Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis · Kang H. Zheng · 2019 · 341 citations · Cited by this paper
  16. Serial OCT-based coronary physiology and plaque composition in vessels with nonobstructive coronary lesions following intensive lipid-lowering therapy: YELLOW III sub-study · 2026 · Related
  17. Lipoprotein(a) Levels, Genotype, and Incident Aortic Valve Stenosis · Benoît J. Arsenault · 2014 · 312 citations · Cited by this paper
  18. Culprit in custody but disease remains at large: OCT substrate and the residual SYNTAX score · 2026 · Related
  19. The Prevalence, Incidence, Progression, and Risks of Aortic Valve Sclerosis · Sean Coffey · 2014 · 255 citations · Cited by this paper
  20. Elevated remnant cholesterol, but not LDL cholesterol, explains part of recurrent ASCVD events in individuals with and without impaired renal function: the Copenhagen General Population Study and the UK Biobank · 2026 · Related
  21. Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation · Silvia Mas‐Peiró · 2019 · 235 citations · Cited by this paper
  22. Cell-Type Transcriptome Atlas of Human Aortic Valves Reveal Cell Heterogeneity and Endothelial to Mesenchymal Transition Involved in Calcific Aortic Valve Disease · Kang Xu · 2020 · 190 citations · Cited by this paper
  23. Evolution and Prognostic Impact of Cardiac Damage After Aortic Valve Replacement · Philippe Généreux · 2022 · 178 citations · Cited by this paper
  24. Effect of Denosumab or Alendronic Acid on the Progression of Aortic Stenosis: A Double-Blind Randomized Controlled Trial · Tania Pawade · 2021 · 152 citations · Cited by this paper
  25. Association of Clonal Hematopoiesis of Indeterminate Potential With Inflammatory Gene Expression in Patients With Severe Degenerative Aortic Valve Stenosis or Chronic Postischemic Heart Failure · Wesley Tyler Abplanalp · 2020 · 149 citations · Cited by this paper
  26. A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis · Sébastien Thériault · 2018 · 144 citations · Cited by this paper
  27. A prospective, double-blind, randomized controlled trial of the angiotensin-converting enzyme inhibitor Ramipril In Aortic Stenosis (RIAS trial) · Sacha Bull · 2015 · 142 citations · Cited by this paper
  28. An Exploratory Analysis of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition and Aortic Stenosis in the FOURIER Trial · Brian A. Bergmark · 2020 · 138 citations · Cited by this paper
  29. PCSK9 R46L Loss-of-Function Mutation Reduces Lipoprotein(a), LDL Cholesterol, and Risk of Aortic Valve Stenosis · Anne Langsted · 2016 · 137 citations · Cited by this paper
  30. Angiotensin Receptor-1 Blocker Inhibits Atherosclerotic Changes and Endothelial Disruption of the Aortic Valve in Hypercholesterolemic Rabbits · Kumiko Arishiro · 2007 · 135 citations · Cited by this paper
  31. Dapagliflozin in Patients Undergoing Transcatheter Aortic-Valve Implantation · Sergio Raposeiras‐Roubín · 2025 · 126 citations · Cited by this paper
  32. Dipeptidyl Peptidase-4 Induces Aortic Valve Calcification by Inhibiting Insulin-Like Growth Factor-1 Signaling in Valvular Interstitial Cells · Bongkun Choi · 2017 · 121 citations · Cited by this paper
  33. Lumican promotes calcific aortic valve disease through H3 histone lactylation · Yuming Huang · 2024 · 119 citations · Cited by this paper
  34. Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study · Hao Yu Chen · 2023 · 116 citations · Cited by this paper
  35. Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis · Mark C. Blaser · 2021 · 109 citations · Cited by this paper
  36. Lipoprotein(a) as a Pharmacological Target: Premises, Promises, and Prospects · Antonio Greco · 2025 · 109 citations · Cited by this paper
  37. Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis · Mark C. Blaser · 2023 · 104 citations · Cited by this paper
  38. Paradoxical Effects of Statins on Aortic Valve Myofibroblasts and Osteoblasts · Bing Wu · 2004 · 96 citations · Cited by this paper
  39. Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis · Nicolas Perrot · 2020 · 92 citations · Cited by this paper

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