Research map: Susceptibility of clinical isolates, laboratory-adapted and drug-resistant herpes simplex virus strains to helicase-primase inhibitor adibelivir (IM-250) and its synergy in combination therapy with acyclovir, penciclovir and foscarnet

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  1. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine · Gertrude B. Elion · 1977 · 1596 citations · Cited by this paper
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  5. 9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group · H. J. Schaeffer · 1978 · 1140 citations · Cited by this paper
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  9. Adenine Arabinoside Therapy of Biopsy-Proved Herpes Simplex Encephalitis · Richard J. Whitley · 1977 · 712 citations · Cited by this paper
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  13. Acyclovir: A Decade Later · Alastair J.J. Wood · 1992 · 410 citations · Cited by this paper
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  15. New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease · Gerald Kleymann · 2002 · 334 citations · Cited by this paper
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  17. Treatment of First Episodes of Genital Herpes Simplex Virus Infection with Oral Acyclovir · Yvonne J. Bryson · 1983 · 317 citations · Cited by this paper
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  19. Valaciclovir · Caroline M. Perry · 1996 · 244 citations · Cited by this paper
  20. Clinical Cure of Herpes Simplex Keratitis by 5-Iodo-2'-Deoxyuridine · Herbert E. Kaufman · 1962 · 242 citations · Cited by this paper
  21. Herpes simplex virus 1 helicase-primase: a complex of three herpes-encoded gene products. · James J. Crute · 1989 · 231 citations · Cited by this paper
  22. Clinical management of herpes simplex virus infections: past, present, and future · Richard J. Whitley · 2018 · 189 citations · Cited by this paper
  23. Therapeutic Antiviral Action of 5-Trifluoromethyl-2′-deoxyuridine in Herpes Simplex Keratitis · Herbert E. Kaufman · 1964 · 175 citations · Cited by this paper
  24. Helicase–Primase Inhibitor Pritelivir for HSV-2 Infection · Anna Wald · 2014 · 175 citations · Cited by this paper
  25. Potent In Vivo Antiviral Activity of the Herpes Simplex Virus Primase-Helicase Inhibitor BAY 57-1293 · Ulrich A. K. Betz · 2002 · 135 citations · Cited by this paper
  26. Agents and strategies in development for improved management of herpes simplex virus infection and disease · Gerald Kleymann · 2005 · 75 citations · Cited by this paper
  27. A helicase-primase drug candidate with sufficient target tissue exposure affects latent neural herpes simplex virus infections · Christian Gege · 2021 · 53 citations · Cited by this paper
  28. A randomized, double-blind, comparative trial comparing high- and standard-dose oral acyclovir for first-episode genital herpes infections · Anna Wald · 1994 · 51 citations · Cited by this paper
  29. Synergistic activity of amenamevir (ASP2151) with nucleoside analogs against herpes simplex virus types 1 and 2 and varicella-zoster virus · Koji Chono · 2012 · 38 citations · Cited by this paper
  30. Single-Dose, Patient-Initiated Amenamevir Therapy for Recurrent Genital Herpes: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study · Makoto Kawashima · 2022 · 27 citations · Cited by this paper
  31. A Generally Applicable, High-Throughput Screening–Compatible Assay to Identify, Evaluate, and Optimize Antimicrobial Agents for Drug Therapy · Gerald Kleymann · 2004 · 26 citations · Cited by this paper
  32. Pharmacokinetics and Safety of Amenamevir in Healthy Subjects: Analysis of Four Randomized Phase 1 Studies · Tomohiro Kusawake · 2017 · 24 citations · Cited by this paper
  33. Helicase primase inhibitors (HPIs) are efficacious for therapy of human herpes simplex virus (HSV) disease in an infection mouse model · Nadja Uhlig · 2021 · 23 citations · Cited by this paper
  34. Management of Refractory/Resistant Herpes Simplex Virus Infections in Haematopoietic Stem Cell Transplantation Recipients: A Literature Review · Léo Sallée · 2024 · 20 citations · Cited by this paper
  35. Intermittent therapy with helicase-primase inhibitor IM-250 efficiently controls recurrent herpes disease and reduces reactivation of latent HSV · David I. Bernstein · 2023 · 19 citations · Cited by this paper
  36. First‐in‐Human, Single‐ and Multiple‐Ascending‐Dose, Food‐Effect, and Absolute Bioavailability Trials to Assess the Pharmacokinetics, Safety, and Tolerability of Pritelivir, a Nonnucleoside Helicase‐Primase Inhibitor Against Herpes Simplex Virus in Healthy Subjects · Dirk Kropeit · 2023 · 17 citations · Cited by this paper
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