Research map: The role of glymphatic dysfunction in cerebral small vessel disease and vascular cognitive impairment, and therapeutic implications

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Papers in this map

  1. A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β · Jeffrey J. Iliff · 2012 · 5918 citations · Cited by this paper
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  5. Brain Infarction and the Clinical Expression of Alzheimer Disease The Nun Study · David A. Snowdon · 1997 · 1598 citations · Cited by this paper
  6. Low-dose rivaroxaban plus antiplatelet therapy for symptomatic intracranial atherosclerotic stenosis: A prospective cohort study · 2026 · Related
  7. Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle · Jae-Eun Kang · 2009 · 1588 citations · Cited by this paper
  8. High ambient temperature, humidity, heat index, and stroke risk in a Mediterranean region · 2026 · Related
  9. The glymphatic pathway in neurological disorders · Martin Kaag Rasmussen · 2018 · 1577 citations · Cited by this paper
  10. Adjunctive intra-arterial alteplase after near-complete or complete reperfusion in acute ischemic stroke: A post hoc analysis of the PEARL Trial · 2026 · Related
  11. Cerebral Arterial Pulsation Drives Paravascular CSF–Interstitial Fluid Exchange in the Murine Brain · Jeffrey J. Iliff · 2013 · 1392 citations · Cited by this paper
  12. Safety and efficacy of early antiplatelet therapy after intravenous thrombolysis for acute ischemic stroke: A comprehensive meta-analysis with trial sequential analysis · 2026 · Related
  13. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep · Nina E. Fultz · 2019 · 1243 citations · Cited by this paper
  14. Small vessel disease burden and response to induced hypertension therapy in small vessel occlusion stroke with early neurological deterioration · 2026 · Related
  15. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases · Toshiaki Taoka · 2017 · 1181 citations · Cited by this paper
  16. Randomization of Endovascular Treatment with Stent-Retriever and/or Thromboaspiration versus Best Medical Therapy in Acute Ischemic Stroke Due to Large Vessel Occlusion in the Extended Time Window Trial (RESILIENT-Extend): Rationale and Design · 2026 · Related
  17. Glymphatic failure as a final common pathway to dementia · Maiken Nedergaard · 2020 · 1159 citations · Cited by this paper
  18. Distinct perforator hemodynamic phenotypes differentiate mechanisms of single subcortical infarction: In vivo evidence from 7T phase-contrast MRI · 2026 · Related
  19. Neuroimaging standards for research into small vessel disease—advances since 2013 · Marco Duering · 2023 · 1124 citations · Cited by this paper
  20. Vascular dementia: World Stroke Organization fact sheet 2026 · 2026 · Related
  21. What are White Matter Hyperintensities Made of? · Joanna Marguerite Wardlaw · 2015 · 948 citations · Cited by this paper
  22. The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI–neuropathology diagnostic accuracy study · Andreas Charidimou · 2022 · 722 citations · Cited by this paper
  23. SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Perivascular Drainage of Amyloid‐β Peptides from the Brain and Its Failure in Cerebral Amyloid Angiopathy and Alzheimer's Disease · Roy O. Weller · 2008 · 702 citations · Cited by this paper
  24. Cerebral Perivascular Spaces Visible on Magnetic Resonance Imaging: Development of a Qualitative Rating Scale and its Observer Reliability · Gillian M. Potter · 2015 · 522 citations · Cited by this paper
  25. Glymphatic clearance function in patients with cerebral small vessel disease · Wen‐Hua Zhang · 2021 · 497 citations · Cited by this paper
  26. Impaired Glymphatic Perfusion After Strokes Revealed by Contrast-Enhanced MRI · Thomas Gaberel · 2014 · 445 citations · Cited by this paper
  27. Sleep deprivation impairs molecular clearance from the human brain · Per Kristian Eide · 2020 · 399 citations · Cited by this paper
  28. Understanding the role of the perivascular space in cerebral small vessel disease · Rosalind Brown · 2018 · 358 citations · Cited by this paper
  29. Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep · Natalie Linea Hauglund · 2025 · 297 citations · Cited by this paper
  30. Impaired Glymphatic Transport in Spontaneously Hypertensive Rats · Kristian Nygaard Mortensen · 2019 · 288 citations · Cited by this paper
  31. Choroid Plexus Volume and Permeability at Brain MRI within the Alzheimer Disease Clinical Spectrum · Jong Duck Choi · 2022 · 282 citations · Cited by this paper
  32. Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts · Minghuan Wang · 2017 · 203 citations · Cited by this paper
  33. Low Frequency Systemic Hemodynamic “Noise” in Resting State BOLD fMRI: Characteristics, Causes, Implications, Mitigation Strategies, and Applications · Yunjie Tong · 2019 · 202 citations · Cited by this paper
  34. Interaction between blood-brain barrier and glymphatic system in solute clearance · Inge C.M. Verheggen · 2018 · 174 citations · Cited by this paper
  35. Perivascular space dilation is associated with vascular amyloid-β accumulation in the overlying cortex · Valentina Perosa · 2021 · 172 citations · Cited by this paper
  36. Intracranial hemodynamic relationships in patients with cerebral small vessel disease · Gordon W. Blair · 2020 · 152 citations · Cited by this paper
  37. Enlarged perivascular spaces and cognition · Saima Hilal · 2018 · 147 citations · Cited by this paper
  38. Visualization of Perivascular Spaces and Perforating Arteries With 7 T Magnetic Resonance Imaging · Willem H. Bouvy · 2014 · 145 citations · Cited by this paper
  39. Repetitive transcranial magnetic stimulation increases the brain’s drainage efficiency in a mouse model of Alzheimer’s disease · Yangyang Lin · 2021 · 139 citations · Cited by this paper

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