Research map: 7-azaindole as privileged scaffold: Advances in drug design and structural modification

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  1. The Hippo pathway: regulators and regulations · Fa‐Xing Yu · 2013 · 1266 citations · Cited by this paper
  2. Small Molecule Insulin Sensitisers: New Leads and Targets for Next-Generation Insulin Sensitising Strategies · 2026 · Related
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  22. CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1–Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma · Lars Henning Engelholm · 2017 · 118 citations · Cited by this paper
  23. Hippo signaling pathway and respiratory diseases · Weifeng Tang · 2022 · 98 citations · Cited by this paper
  24. A self-assembled, ROS-responsive Janus-prodrug for targeted therapy of inflammatory bowel disease · Shanshan Li · 2019 · 97 citations · Cited by this paper
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  26. Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer · Tingting Chen · 2023 · 94 citations · Cited by this paper
  27. Design, Synthesis, and Biological Evaluation of Potent c-Met Inhibitors · Noel D. D’Angelo · 2008 · 92 citations · Cited by this paper
  28. PDK1 promotes tumor cell proliferation and migration by enhancing the Warburg effect in non-small cell lung cancer · Tao Liu · 2016 · 87 citations · Cited by this paper
  29. Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors · Jeffrey T. Bagdanoff · 2019 · 86 citations · Cited by this paper
  30. Development of pyruvate dehydrogenase kinase inhibitors in medicinal chemistry with particular emphasis as anticancer agents · Shaolin Zhang · 2015 · 85 citations · Cited by this paper
  31. 7-Azaindole: A Versatile Scaffold for Developing Kinase Inhibitors · Takayuki Irie · 2017 · 85 citations · Cited by this paper
  32. A nanocleaner specifically penetrates the blood‒brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer's disease · Ting Lei · 2021 · 83 citations · Cited by this paper
  33. Targeting Undruggable Transcription Factors with PROTACs: Advances and Perspectives · Yan Li · 2022 · 83 citations · Cited by this paper
  34. Resveratrol exerts dose-dependent anti-fibrotic or pro-fibrotic effects in kidneys: A potential risk to individuals with impaired kidney function · Shuyun Liu · 2018 · 77 citations · Cited by this paper
  35. Hematopoietic progenitor kinase 1 is a critical component of prostaglandin E2-mediated suppression of the anti-tumor immune response · Saba Alzabin · 2009 · 75 citations · Cited by this paper
  36. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives · Fernanda Neumann · 2018 · 73 citations · Cited by this paper
  37. Erianin inhibits human lung cancer cell growth via PI3K /Akt/ mTOR pathway in vitro and in vivo · Huiqiong Zhang · 2021 · 68 citations · Cited by this paper
  38. Checking NEKs: Overcoming a Bottleneck in Human Diseases · Andressa Peres de Oliveira · 2020 · 67 citations · Cited by this paper
  39. The COP9 signalosome: A versatile regulatory hub of Cullin-RING ligases · Eric Schulze · 2022 · 65 citations · Cited by this paper

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