Research map: Histone deacetylase inhibitors enhance the amoebicidal activity of amphotericin B against Naegleria fowleri

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  1. Histone deacetylase inhibitors: molecular mechanisms of action · Weisheng Xu · 2007 · 1554 citations · Cited by this paper
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  13. A Phase I Study of Quisinostat (JNJ-26481585), an Oral Hydroxamate Histone Deacetylase Inhibitor with Evidence of Target Modulation and Antitumor Activity, in Patients with Advanced Solid Tumors · Balaji Venugopal · 2013 · 125 citations · Cited by this paper
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  15. Primary Amoebic Meningoencephalitis by Naegleria fowleri: Pathogenesis and Treatments · Andrea Güémez · 2021 · 119 citations · Cited by this paper
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  17. Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni · Florence Dubois · 2009 · 114 citations · Cited by this paper
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  21. Synergistic Activities of Azithromycin and Amphotericin B against Naegleria fowleri In Vitro and in a Mouse Model of Primary Amebic Meningoencephalitis · Shannon M. Soltow · 2006 · 84 citations · Cited by this paper
  22. Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae · Christopher A. Rice · 2020 · 68 citations · Cited by this paper
  23. Phase II multicentre trial of oral quisinostat, a histone deacetylase inhibitor, in patients with previously treated stage IB – IVA mycosis fungoides/Sézary syndrome · Fiona J. Child · 2016 · 64 citations · Cited by this paper
  24. SCRIPTAID AND SUBEROYLANILIDE HYDROXAMIC ACID ARE HISTONE DEACETYLASE INHIBITORS WITH POTENT ANTI–TOXOPLASMA GONDII ACTIVITY IN VITRO · Jeannine S. Strobl · 2007 · 61 citations · Cited by this paper
  25. Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite · Giuseppe Giannini · 2014 · 45 citations · Cited by this paper
  26. Advancing the understanding of Naegleria fowleri: Global epidemiology, phylogenetic analysis, and strategies to combat a deadly pathogen · Awadh Alanazi · 2025 · 38 citations · Cited by this paper
  27. Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei · John M. Kelly · 2012 · 33 citations · Cited by this paper
  28. HDAC inhibitors Tubastatin A and SAHA affect parasite cell division and are potential anti-Toxoplasma gondii chemotherapeutics · Carlla Assis Araújo-Silva · 2020 · 32 citations · Cited by this paper
  29. Occurrence of Naegleria fowleri and their implication for health - a look under the One Health approaches · Denise Leal dos Santos · 2022 · 26 citations · Cited by this paper
  30. Quisinostat is a brain-penetrant radiosensitizer in glioblastoma · Costanza Lo Cascio · 2023 · 26 citations · Cited by this paper
  31. Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production · Alessandra Guidi · 2018 · 22 citations · Cited by this paper
  32. Amphotericin B Penetrates into the Central Nervous System through Focal Disruption of the Blood-Brain Barrier in Experimental Hematogenous Candida Meningoencephalitis · Vidmantas Petraitis · 2019 · 22 citations · Cited by this paper
  33. Studies on the cyst stage of Naegleria fowleri in vivo and in vitro · Anna L Evdokiou · 2021 · 15 citations · Cited by this paper
  34. Successful Treatment of Confirmed Naegleria fowleri Primary Amebic Meningoencephalitis · Ahmed Mujadid Khan Burqi · 2024 · 15 citations · Cited by this paper
  35. A Fluorometric Assay for the In Vitro Evaluation of Activity against Naegleria fowleri Cysts · Iñigo Arberas-Jiménez · 2022 · 12 citations · Cited by this paper
  36. Antiproliferation and Antiencystation Effect of Class II Histone Deacetylase Inhibitors on Acanthamoeba castellanii · Ki‐Back Chu · 2022 · 11 citations · Cited by this paper
  37. HDAC inhibitors as anticancer drugs: chemical diversity, clinical trials, challenges and perspectives · A. AbdAllah · 2026 · 9 citations · Cited by this paper
  38. Histone Deacetylase Inhibitors Show a Potential Leishmanicidal Effect against Leishmania braziliensis in a Mouse Infection Model and Lead to Less Toxicity than Glucantime · Luciana Ângelo de Souza · 2025 · 6 citations · Cited by this paper
  39. Combination of tert-butyl hydroperoxide with vorinostat induces cell death of Acanthamoeba through cell cycle arrest · Hae‐Ahm Lee · 2020 · 4 citations · Cited by this paper

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