Research map: Decoding Context-Dependent Sirtuin Pharmacology in Cancer: Metabolic–Epigenetic Switches and Precision Therapeutic Targeting

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  1. HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS · Thomas Walle · 2004 · 1873 citations · Cited by this paper
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  11. Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells · Imène Hamaidi · 2020 · 165 citations · Cited by this paper
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  13. SIRT2‐dependent IDH1 deacetylation inhibits colorectal cancer and liver metastases · Bo Wang · 2020 · 135 citations · Cited by this paper
  14. Extracellular vesicle-mediated immunity-coagulation interaction in cancer-associated thrombosis during the immunotherapy era · 2026 · Related
  15. TSPAN8 + myofibroblastic cancer–associated fibroblasts promote chemoresistance in patients with breast cancer · Guangjian Fan · 2024 · 100 citations · Cited by this paper
  16. Revisiting Diffuse Gliomas in the Era of Precision Medicine: Molecular Insights and Therapeutic Implications · 2026 · Related
  17. Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway · Fuqing Hu · 2018 · 98 citations · Cited by this paper
  18. Liquid biopsy for early cancer detection in hereditary cancer syndromes: Current evidence · 2026 · Related
  19. Biochemical mechanism and biological effects of the inhibition of silent information regulator 1 (SIRT1) by EX-527 (SEN0014196 or selisistat) · Sylvain Broussy · 2020 · 93 citations · Cited by this paper
  20. Current status and prospects of chemotherapy-free strategies in ovarian cancer · 2026 · Related
  21. Targeting sirtuins for cancer therapy: epigenetics modifications and beyond · Hui Shen · 2024 · 92 citations · Cited by this paper
  22. Discovery of Novel PROTAC SIRT6 Degraders with Potent Efficacy against Hepatocellular Carcinoma · Jinbo Huang · 2024 · 62 citations · Cited by this paper
  23. SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation · Xiuli Yi · 2023 · 52 citations · Cited by this paper
  24. SIRT1 promotes glucolipid metabolic conversion to facilitate tumor development in colorectal carcinoma · Zhihao Wei · 2023 · 50 citations · Cited by this paper
  25. The histone deacetylase SIRT6 promotes glycolysis through the HIF-1α/HK2 signaling axis and induces erlotinib resistance in non-small cell lung cancer · Qiai You · 2022 · 44 citations · Cited by this paper
  26. miR-224 aggravates cancer-associated fibroblast-induced progression of non-small cell lung cancer by modulating a positive loop of the SIRT3/AMPK/mTOR/HIF-1α axis · Juan Zhang · 2021 · 42 citations · Cited by this paper
  27. Inhibition of SIRT6 potentiates the anti-tumor effect of doxorubicin through suppression of the DNA damage repair pathway in osteosarcoma · Zhongkai Zhang · 2020 · 40 citations · Cited by this paper
  28. SIRT1 ‐mediated deacetylation of FOXO3a transcription factor supports pro‐angiogenic activity of interferon‐deficient tumor‐associated neutrophils · Sharareh Bordbari · 2021 · 36 citations · Cited by this paper
  29. SIRT1 deacetylates WEE1 and sensitizes cancer cells to WEE1 inhibition · Xiaomei Zhu · 2023 · 35 citations · Cited by this paper
  30. The PIK3CA-E545K-SIRT4 signaling axis reduces radiosensitivity by promoting glutamine metabolism in cervical cancer · Wei Jiang · 2023 · 35 citations · Cited by this paper
  31. SIRT3 Functions as an Eraser of Histone H3K9 Lactylation to Modulate Transcription for Inhibiting the Progression of Esophageal Cancer · Chen Chen · 2025 · 34 citations · Cited by this paper
  32. SIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axis · Xiaowei Wang · 2023 · 32 citations · Cited by this paper
  33. NAD+ supplementation limits triple-negative breast cancer metastasis via SIRT1-P66Shc signaling · Yi Jiang · 2023 · 29 citations · Cited by this paper
  34. The role of SIRT1 in autophagy and drug resistance: unveiling new targets and potential biomarkers in cancer therapy · Yujing Tang · 2024 · 29 citations · Cited by this paper
  35. Cancer-associated fibroblasts in the tumor microenvironment: heterogeneity, crosstalk mechanisms, and therapeutic implications · Ziyue Huang · 2025 · 28 citations · Cited by this paper
  36. PROTAC Technology as a New Tool for Modern Pharmacotherapy · Natalia Kubryń · 2025 · 27 citations · Cited by this paper
  37. Role of SIRT2 in Regulation of Stemness of Cancer Stem-Like Cells in Renal Cell Carcinoma · Ruojing Wei · 2018 · 26 citations · Cited by this paper
  38. SUMOylation is essential for Sirt2 tumor-suppressor function in neuroblastoma · Wenmei Lu · 2020 · 25 citations · Cited by this paper
  39. Mitochondrial Sirtuins in Chronic Degenerative Diseases: New Metabolic Targets in Colorectal Cancer · Antonino Colloca · 2022 · 22 citations · Cited by this paper

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