Research map: Hepatotoxicity in the Era of Precision Medicine: Toxicological Mechanisms and Management of Immune and Cell Therapy‐Induced Liver Injury

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  1. The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis · Patrick M. Smith · 2013 · 5491 citations · Cited by this paper
  2. A Possibility of Synthetic Lethality: Wee1 Kinase as a Promising Treating Target for Cancer · 2026 · Related
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  6. Exercise‐Induced Exerkines: Multi‐Nodal Suppression of the NLRP3 Inflammasome and Translational Potential · 2026 · Related
  7. Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance · Filipe Martins · 2019 · 2339 citations · Cited by this paper
  8. Advances in SIRT2‐Targeted Therapeutics: Structural Insights, Chemical Strategies, and Degrader Technologies · 2026 · Related
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  10. AI‐Driven Multi‐Omics Integrated Applications Using Diverse Neural Networks for Breast Cancer Diagnostic Screening and Biomarker Discovery · 2026 · Related
  11. Immunotherapies for hepatocellular carcinoma · Josep Maria Llovet · 2021 · 1895 citations · Cited by this paper
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  13. Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia · Joseph A. Fraietta · 2018 · 1842 citations · Cited by this paper
  14. FDA‐Approved Pyrimidine‐Containing Drugs: Synthesis and Clinical Application · 2025 · Related
  15. Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma · Toni K. Choueiri · 2021 · 1801 citations · Cited by this paper
  16. Senotherapeutics for Knee Osteoarthritis · 2026 · Related
  17. Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients · Diwakar Davar · 2021 · 1752 citations · Cited by this paper
  18. Hepatic Effects, Potential Drug-Induced Liver Injury, and Other Liver Safety Considerations of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in the New Era of Expanding Non-oncology Indications: Literature Review and Expert Consensus · 2025 · Related
  19. Updated efficacy and safety data from IMbrave150: Atezolizumab plus bevacizumab vs. sorafenib for unresectable hepatocellular carcinoma · Ann‐Lii Cheng · 2021 · 1752 citations · Cited by this paper
  20. Safety and efficacy of blinatumomab: a real world data · 2020 · Related
  21. Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients · Erez N. Baruch · 2020 · 1730 citations · Cited by this paper
  22. Human organs-on-chips for disease modelling, drug development and personalized medicine · Donald E. Ingber · 2022 · 1562 citations · Cited by this paper
  23. Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy · Antonio Di Stasi · 2011 · 1532 citations · Cited by this paper
  24. Immune-related adverse events of checkpoint inhibitors · Manuel Ramos‐Casals · 2020 · 1441 citations · Cited by this paper
  25. Mycophenolate mofetil and its mechanisms of action · ANTHONY C. ALLISON · 2000 · 1438 citations · Cited by this paper
  26. Bispecific antibodies: a mechanistic review of the pipeline · Aran F. Labrijn · 2019 · 1332 citations · Cited by this paper
  27. Multimodal biomedical AI · Julián Acosta · 2022 · 1325 citations · Cited by this paper
  28. Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade · Spencer C. Wei · 2017 · 1319 citations · Cited by this paper
  29. Management of toxicities from immunotherapy: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up · John B.A.G. Haanen · 2022 · 1289 citations · Cited by this paper
  30. Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib · Thomas C. C. Yau · 2020 · 1278 citations · Cited by this paper
  31. Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma · Gerald P. Linette · 2013 · 1202 citations · Cited by this paper
  32. Immune-related adverse events and anti-tumor efficacy of immune checkpoint inhibitors · Satya Das · 2019 · 1176 citations · Cited by this paper
  33. Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy · Emma C. Morris · 2021 · 1120 citations · Cited by this paper
  34. Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis · Xinyang Song · 2019 · 1036 citations · Cited by this paper
  35. Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer · Lisa Derosa · 2018 · 908 citations · Cited by this paper
  36. Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune checkpoint inhibitor-related adverse events · Julie Renee Brahmer · 2021 · 894 citations · Cited by this paper
  37. Immune Checkpoint Inhibitor Rechallenge After Immune-Related Adverse Events in Patients With Cancer · Charles Dolladille · 2020 · 604 citations · Cited by this paper
  38. Characterization of liver injury induced by cancer immunotherapy using immune checkpoint inhibitors · Eléonora De Martin · 2018 · 551 citations · Cited by this paper
  39. Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation · Mohamad Mohty · 2016 · 543 citations · Cited by this paper

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