Research map: Thrombomodulin Gly430Ser mutation attenuates the affinity with thrombin and contributes to thrombosis development

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  19. The Last Three Consecutive Epidermal Growth Factor-like Structures of Human Thrombomodulin Comprise the Minimum Functional Domain for Protein C-activating Cofactor Activity and Anticoagulant Activity · M Zushi · 1989 · 154 citations · Cited by this paper
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  22. Functionally Active Thrombomodulin Is Present in Human Platelets1 · Koji Suzuki · 1988 · 109 citations · Cited by this paper
  23. Functional domains of membrane-bound human thrombomodulin. EGF-like domains four to six and the serine/threonine-rich domain are required for cofactor activity. · Manuel Tsiang · 1992 · 106 citations · Cited by this paper
  24. Thrombomodulin: An overview and potential implications in vascular disorders · M C Boffa · 1998 · 106 citations · Cited by this paper
  25. Thrombin-Cofactor Interactions · Ty E. Adams · 2006 · 105 citations · Cited by this paper
  26. Activation of Thrombin-activable Fibrinolysis Inhibitor Requires Epidermal Growth Factor-like Domain 3 of Thrombomodulin and Is Inhibited Competitively by Protein C · Koichi Kokame · 1998 · 101 citations · Cited by this paper
  27. Thrombin Interacts with Thrombomodulin, Protein C, and Thrombin-activatable Fibrinolysis Inhibitor via Specific and Distinct Domains · Scott W. Hall · 1999 · 99 citations · Cited by this paper
  28. Thrombomodulin modulates growth of tumor cells independent of its anticoagulant activity. · Y Zhang · 1998 · 95 citations · Cited by this paper
  29. Alanine-scanning mutagenesis of the epidermal growth factor-like domains of human thrombomodulin identifies critical residues for its cofactor activity. · M. Nagashima · 1993 · 81 citations · Cited by this paper
  30. Expression of Thrombomodulin in Atherosclerotic Lesions and Mitogenic Activity of Recombinant Thrombomodulin in Vascular Smooth Muscle Cells · Gen Tohda · 1998 · 74 citations · Cited by this paper
  31. The epidermal growth factor-like domain of recombinant human thrombomodulin exhibits mitogenic activity for Swiss 3T3 cells · Hiroyuki Hamada · 1995 · 49 citations · Cited by this paper
  32. Platelet factor 4 stimulates thrombomodulin protein C-activating cofactor activity. A structure-function analysis. · Arne Slungaard · 1994 · 44 citations · Cited by this paper
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  34. Prospective study of the A455V polymorphism in the thrombomodulin gene, plasma thrombomodulin, and incidence of venous thromboembolism: the LITE Study · Nena Aleksic · 2003 · 36 citations · Cited by this paper
  35. Association of the Thrombomodulin Gene c.1418C>T Polymorphism With Thrombomodulin Levels and With Venous Thrombosis Risk · Silvia Navarro · 2013 · 33 citations · Cited by this paper
  36. Structure of the fifth EGF-like domain of thrombomodulin: an EGF-like domain with a novel disulfide-bonding pattern 1 1Edited by P. E. Wright · Benedetta Alessandra Sampoli Benitez · 1997 · 32 citations · Cited by this paper
  37. Thrombomodulin and Endothelial Dysfunction: A Disease-Modifier Shared between Malignant Hypertension and Atypical Hemolytic Uremic Syndrome · Marieke Demeulenaere · 2018 · 26 citations · Cited by this paper
  38. A case of thrombomodulin mutation causing defective thrombin binding with absence of protein C and TAFI activation · Masahiko Okada · 2020 · 25 citations · Cited by this paper
  39. Thrombomodulin gene c.1418C>T polymorphism and risk of recurrent venous thromboembolism · Abrar Ahmad · 2016 · 20 citations · Cited by this paper

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