Research map: Molecular grappling: the complex interplay involving human herpesviruses, small ubiquitin-like modifier (SUMO), and the host immune system

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  1. Function and regulation of SUMO proteases · Christopher M. Hickey · 2012 · 652 citations · Cited by this paper
  2. Beyond the liver: the broadened tissue tropism of hepatitis E virus · 2026 · Related
  3. Role of SUMO-1–modified PML in nuclear body formation · Sue Zhong · 2000 · 564 citations · Cited by this paper
  4. Molecular dialogues in plant rhabdovirus–host interactions · 2026 · Related
  5. The Mechanisms of PML-Nuclear Body Formation · Tian Huai Shen · 2006 · 525 citations · Cited by this paper
  6. New directions in the multifunctionality of RNA viruses: insights from the rabies virus P-protein · 2025 · Related
  7. Herpes virus induced proteasome-dependent degradation of the nuclear bodies-associated PML and Sp100 proteins · Mounira K. Chelbi‐Alix · 1999 · 336 citations · Cited by this paper
  8. Orthobunyavirus entry: receptors, endocytosis, and fusion cues · 2026 · Related
  9. Viral Immediate-Early Proteins Abrogate the Modification by SUMO-1 of PML and Sp100 Proteins, Correlating with Nuclear Body Disruption · Stefan P Müller · 1999 · 308 citations · Cited by this paper
  10. Respiratory syncytial virus (RSV) and influenza A virus (IAV) interplay with the type I and III interferon (IFN) responses in the respiratory epithelium · 2026 · Related
  11. SUMO conjugation – a mechanistic view · Andrea Pichler · 2017 · 274 citations · Cited by this paper
  12. Virological and immunological determinants of hepatitis E virus infection outcomes · 2025 · Related
  13. Epstein-Barr Virus Immediate-Early Protein BZLF1 Is SUMO-1 Modified and Disrupts Promyelocytic Leukemia Bodies · Amy L. Adamson · 2001 · 232 citations · Cited by this paper
  14. Beyond brain fog: viral proteins as convergent drivers of neuroinflammation and proteinopathy · 2026 · Related
  15. Replication of ICP0-Null Mutant Herpes Simplex Virus Type 1 Is Restricted by both PML and Sp100 · Roger D. Everett · 2007 · 218 citations · Cited by this paper
  16. Inborn errors of autophagy underlying severe viral infections in humans · 2026 · Related
  17. Emerging Role of PML Nuclear Bodies in Innate Immune Signaling · Myriam Scherer · 2016 · 189 citations · Cited by this paper
  18. A storm is born: immune activation and pathogenesis in arthritogenic alphavirus infections · 2025 · Related
  19. Disruption of PML Subnuclear Domains by the Acidic IE1 Protein of Human Cytomegalovirus Is Mediated through Interaction with PML and May Modulate a RING Finger-Dependent Cryptic Transactivator Function of PML · Jin-Hyun Ahn · 1998 · 176 citations · Cited by this paper
  20. Use of age-specific human in vitro platforms to advance discovery and development of novel vaccine adjuvants · 2026 · Related
  21. Covalent Modification of the Transactivator Protein IE2-p86 of Human Cytomegalovirus by Conjugation to the Ubiquitin-Homologous Proteins SUMO-1 and hSMT3b · Heike Hofmann · 2000 · 165 citations · Cited by this paper
  22. Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase · Laurent Cappadocia · 2015 · 150 citations · Cited by this paper
  23. Ability of the Human Cytomegalovirus IE1 Protein To Modulate Sumoylation of PML Correlates with Its Functional Activities in Transcriptional Regulation and Infectivity in Cultured Fibroblast Cells · Hye-Ra Lee · 2004 · 141 citations · Cited by this paper
  24. Entrapment of Viral Capsids in Nuclear PML Cages Is an Intrinsic Antiviral Host Defense against Varicella-Zoster Virus · Mike Reichelt · 2011 · 109 citations · Cited by this paper
  25. ICP0 Induces the Accumulation of Colocalizing Conjugated Ubiquitin · Roger D. Everett · 2000 · 105 citations · Cited by this paper
  26. Evaluation of Interactions of Human Cytomegalovirus Immediate-Early IE2 Regulatory Protein with Small Ubiquitin-Like Modifiers and Their Conjugation Enzyme Ubc9 · Jin‐Hyun Ahn · 2001 · 101 citations · Cited by this paper
  27. SUMO Interacting Motifs: Structure and Function · Tak Yu Yau · 2021 · 95 citations · Cited by this paper
  28. Mechanisms and functions of SUMOylation in health and disease: a review focusing on immune cells · Chien-Hsin Huang · 2024 · 95 citations · Cited by this paper
  29. Kaposi's Sarcoma-associated Herpesvirus (KSHV) Encodes a SUMO E3 ligase That Is SIM-dependent and SUMO-2/3-specific · Pei‐Ching Chang · 2009 · 92 citations · Cited by this paper
  30. Kaposi's Sarcoma-Associated Herpesvirus Protein LANA2 Disrupts PML Oncogenic Domains and Inhibits PML-Mediated Transcriptional Repression of the Survivin Gene · Laura Marcos-Villar · 2009 · 84 citations · Cited by this paper
  31. Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease · Daniel Bailey · 2002 · 77 citations · Cited by this paper
  32. SUMO Binding by the Epstein-Barr Virus Protein Kinase BGLF4 Is Crucial for BGLF4 Function · Renfeng Li · 2012 · 75 citations · Cited by this paper
  33. Cooperativity of the SUMO and Ubiquitin Pathways in Genome Stability · Minghua Nie · 2016 · 75 citations · Cited by this paper
  34. A Unique SUMO-2-Interacting Motif within LANA Is Essential for KSHV Latency · Qiliang Cai · 2013 · 74 citations · Cited by this paper
  35. Disruption of PML Nuclear Bodies Is Mediated by ORF61 SUMO-Interacting Motifs and Required for Varicella-Zoster Virus Pathogenesis in Skin · Li Wang · 2011 · 72 citations · Cited by this paper
  36. Kaposi's Sarcoma-Associated Herpesvirus K-Rta Exhibits SUMO-Targeting Ubiquitin Ligase (STUbL) Like Activity and Is Essential for Viral Reactivation · Yoshihiro Izumiya · 2013 · 68 citations · Cited by this paper
  37. SUMO-1 Modification of Human Cytomegalovirus IE1/IE72 · Mary L. Spengler · 2002 · 63 citations · Cited by this paper
  38. Human Herpesvirus 6 Immediate-Early 1 Protein Is a Sumoylated Nuclear Phosphoprotein Colocalizing with Promyelocytic Leukemia Protein-associated Nuclear Bodies · Annie Gravel · 2002 · 61 citations · Cited by this paper
  39. Histone Demethylase JMJD2A Regulates Kaposi's Sarcoma-Associated Herpesvirus Replication and Is Targeted by a Viral Transcriptional Factor · Pei‐Ching Chang · 2011 · 56 citations · Cited by this paper

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