Research map: Obacunone attenuates Cholestatic liver disease via PPARα activation and gut microbiota remodeling

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Papers in this map

  1. Bile acids and the gut microbiota: metabolic interactions and impacts on disease · Stephanie L. Collins · 2022 · 1204 citations · Cited by this paper
  2. Targeting KIF11 degradation: Oxypeucedanin inhibits lung adenocarcinoma progression by disrupting the MCM2-CDK1 signaling pathway · 2026 · Related
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  11. Protocol for Primary Mouse Hepatocyte Isolation · Meital Charni‐Natan · 2020 · 443 citations · Cited by this paper
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  13. Bile Acid Sulfation: A Pathway of Bile Acid Elimination and Detoxification · Yazen Alnouti · 2009 · 405 citations · Cited by this paper
  14. Curculigoside A alleviates metabolic dysfunction-associated steatohepatitis by targeting Rab30 to improve lipid homeostasis · 2026 · Related
  15. Efficacy of Ursodeoxycholic Acid in Treating Intrahepatic Cholestasis of Pregnancy: A Meta-analysis · Yannick Bacq · 2012 · 286 citations · Cited by this paper
  16. PPARα modulation of macrophage polarization and inflammatory signaling in mimic periodontitis · 2025 · Related
  17. Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method · Juan Carlos García‐Cañaveras · 2012 · 278 citations · Cited by this paper
  18. Tanshinone I as a novel ferritinophagy inducer triggers ferroptosis to suppress gastric cancer growth · 2026 · Related
  19. Bile acid metabolism and signalling in liver disease · Claudia Daniela Fuchs · 2024 · 225 citations · Cited by this paper
  20. Bile acids as gatekeepers: Orchestrating gut-liver axis for metabolic and immune balance · 2026 · Related
  21. Novel insight into mechanisms of cholestatic liver injury · Benjamin Leeland Woolbright · 2012 · 204 citations · Cited by this paper
  22. Novel therapeutic targets for cholestatic and fatty liver disease · Michael A Trauner · 2021 · 201 citations · Cited by this paper
  23. Estrogen Receptor α Mediates 17α-Ethynylestradiol Causing Hepatotoxicity · Yukio Yamamoto · 2006 · 180 citations · Cited by this paper
  24. Obacunone alleviates ferroptosis during lipopolysaccharide-induced acute lung injury by upregulating Nrf2-dependent antioxidant responses · Jin Li · 2022 · 180 citations · Cited by this paper
  25. Clinical trial: effectiveness of Lactobacillus rhamnosus (strains E/N, Oxy and Pen) in the prevention of antibiotic‐associated diarrhoea in children · Marek Ruszczyński · 2008 · 132 citations · Cited by this paper
  26. Bacteroides uniformis-induced perturbations in colonic microbiota and bile acid levels inhibit TH17 differentiation and ameliorate colitis developments · Yiting Yan · 2023 · 124 citations · Cited by this paper
  27. Gut Microbiota Analysis in Rats with Methamphetamine-Induced Conditioned Place Preference · Tingting Ning · 2017 · 115 citations · Cited by this paper
  28. Bile acid homeostasis in female mice deficient in Cyp7a1 and Cyp27a1 · Daniel Rizzolo · 2021 · 104 citations · Cited by this paper
  29. Cholestatic liver diseases of genetic etiology: Advances and controversies · Samar H. Ibrahim · 2022 · 70 citations · Cited by this paper
  30. Current Clinical Trial Status and Future Prospects of PPAR-Targeted Drugs for Treating Nonalcoholic Fatty Liver Disease · Shotaro Kamata · 2023 · 67 citations · Cited by this paper
  31. Obacunone Protects Against Ulcerative Colitis in Mice by Modulating Gut Microbiota, Attenuating TLR4/NF-κB Signaling Cascades, and Improving Disrupted Epithelial Barriers · Xiaoping Luo · 2020 · 59 citations · Cited by this paper
  32. Obacunone targets macrophage migration inhibitory factor (MIF) to impede osteoclastogenesis and alleviate ovariectomy-induced bone loss · Jianbo He · 2023 · 53 citations · Cited by this paper
  33. Obacunone Attenuates Liver Fibrosis with Enhancing Anti-Oxidant Effects of GPx-4 and Inhibition of EMT · Yongquan Bai · 2021 · 48 citations · Cited by this paper
  34. Dietary obacunone supplementation stimulates muscle hypertrophy, and suppresses hyperglycemia and obesity through the TGR5 and PPARγ pathway · Taro Horiba · 2015 · 48 citations · Cited by this paper
  35. Inhibition of NLRP3-mediated crosstalk between hepatocytes and liver macrophages by geniposidic acid alleviates cholestatic liver inflammatory injury · Meng Song · 2022 · 47 citations · Cited by this paper
  36. Lactobacillus gasseri RW2014 Ameliorates Hyperlipidemia by Modulating Bile Acid Metabolism and Gut Microbiota Composition in Rats · Xianping Li · 2022 · 47 citations · Cited by this paper
  37. Mitochondrial Bioenergetics of Extramammary Tissues in Lactating Dairy Cattle · Victoria Favorit · 2021 · 38 citations · Cited by this paper
  38. Inhibition of ATGL alleviates MASH via impaired PPARα signalling that favours hydrophilic bile acid composition in mice · Emmanuel Dauda Dixon · 2024 · 38 citations · Cited by this paper
  39. Targeting c-Jun inhibits fatty acid oxidation to overcome tamoxifen resistance in estrogen receptor-positive breast cancer · Cen Jiang · 2023 · 36 citations · Cited by this paper

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