Research map: Harnessing chitosan-based biomaterials for advanced cancer immunotherapy: from nanocarriers to tumor microenvironment modulation

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Papers in this map

  1. Chitosan: Structural modification, biological activity and application · Wenjie Wang · 2020 · 651 citations · Cited by this paper
  2. Breaking the self-reinforcing cycle of aging: Biomaterial strategies for aged bone regeneration · Yihan Wang · 2026 · Cites this paper
  3. A programmable nanoplatform for inflammatory-state reprogramming in psoriasis treatment · 2026 · Related
  4. Combinatorial Photothermal and Immuno Cancer Therapy Using Chitosan-Coated Hollow Copper Sulfide Nanoparticles · Liangran Guo · 2014 · 533 citations · Cited by this paper
  5. HAMA microneedles patch loaded with muscle-targeting engineered apoptotic vesicles and attenuating sarcopenia by regulating mitochondrial homeostasis · 2026 · Related
  6. Chitins and Chitosans as Immunoadjuvants and Non-Allergenic Drug Carriers · Riccardo A.A. Müzzarelli · 2010 · 416 citations · Cited by this paper
  7. Mitochondrial transfer via ADSC-EVs reprograms glucose/glutamine metabolism to restore TCA cycle-driven M2 polarization in diabetic wounds · 2026 · Related
  8. Chitin regulation of immune responses: an old molecule with new roles · Chun Geun Lee · 2008 · 398 citations · Cited by this paper
  9. Magnetic field-controlled nanozymes effectively overcome therapeutic limitations in tumor ferroptosis therapy · 2026 · Related
  10. Enhanced antitumor immunity by targeting dendritic cells with tumor cell lysate-loaded chitosan nanoparticles vaccine · Gaona Shi · 2016 · 307 citations · Cited by this paper
  11. Layered double hydroxide-based ROS-scavenging nanozyme hydrogels re-establish osteoimmune-angiogenic coupling for osteoporotic bone repair · 2026 · Related
  12. Tumor Microenvironment Responsive Nanogel for the Combinatorial Antitumor Effect of Chemotherapy and Immunotherapy · Qingle Song · 2017 · 257 citations · Cited by this paper
  13. Synergistic Effect of Anti-PD-L1 Treatment and CD8+ T-Cell Activating Nanotherapy in Pancreatic Ductal Adenocarcinoma Evaluated via 3D Mathematical Modeling · 2025 · Related
  14. Inhibitory effects of chitooligosaccharides on tumor growth and metastasis · Kun-Te Shen · 2009 · 207 citations · Cited by this paper
  15. Nanoparticles and their significant risks: a comprehensive review of toxicological and regulatory perspectives · 2026 · Related
  16. Antitumor Effects of Various Low-Molecular-Weight Chitosans Are Due to Increased Natural Killer Activity of Intestinal Intraepithelial Lymphocytes in Sarcoma 180–Bearing Mice · Yasunori Maeda · 2004 · 191 citations · Cited by this paper
  17. Virosome-masked ratiometric nanoprobes for in vivo dynamic imaging of influenza a virus infection · 2026 · Related
  18. Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells · Yudong Song · 2018 · 189 citations · Cited by this paper
  19. Schwann cell-derived extracellular vesicles promote periodontal tissue regeneration · 2026 · Related
  20. CD73 specific siRNA loaded chitosan lactate nanoparticles potentiate the antitumor effect of a dendritic cell vaccine in 4T1 breast cancer bearing mice · Farhad Jadidi‐Niaragh · 2016 · 183 citations · Cited by this paper
  21. Exploration of the Synergistic Effect of Chitosan Oligosaccharide and Dacarbazine (DTIC) in the Treatment of Melanoma · 2026 · Related
  22. A magnetic chitosan hydrogel for sustained and prolonged delivery of Bacillus Calmette–Guérin in the treatment of bladder cancer · Dong Zhang · 2013 · 171 citations · Cited by this paper
  23. Review: Application of chitosan and its derivatives in medical materials · Wen Tang · 2023 · 170 citations · Cited by this paper
  24. Mannosylated chitosan nanoparticle–based cytokine gene therapy suppressed cancer growth in BALB/c mice bearing CT-26 carcinoma cells · Tae Hee Kim · 2006 · 164 citations · Cited by this paper
  25. Injectable Immunotherapeutic Hydrogel Containing RNA-Loaded Lipid Nanoparticles Reshapes Tumor Microenvironment for Pancreatic Cancer Therapy · Chao Gao · 2022 · 131 citations · Cited by this paper
  26. A chitosan hydrogel-based cancer drug delivery system exhibits synergistic antitumor effects by combining with a vaccinia viral vaccine · Hee Dong Han · 2007 · 122 citations · Cited by this paper
  27. Folic Acid-Chitosan Conjugated Nanoparticles for Improving Tumor-Targeted Drug Delivery · Huijuan Song · 2013 · 121 citations · Cited by this paper
  28. Construction of a core-shell microneedle system to achieve targeted co-delivery of checkpoint inhibitors for melanoma immunotherapy · Peipei Yang · 2020 · 117 citations · Cited by this paper
  29. Protective effect of chitooligosaccharides against cyclophosphamide-induced immunosuppression in mice · Yuxia Mei · 2013 · 111 citations · Cited by this paper
  30. Oral Nanomotor‐Enabled Mucus Traverse and Tumor Penetration for Targeted Chemo‐Sono‐Immunotherapy against Colon Cancer · Yingui Cao · 2022 · 108 citations · Cited by this paper
  31. Therapeutic targeting of chitosan–PEG–folate-complexed oncolytic adenovirus for active and systemic cancer gene therapy · Oh-Joon Kwon · 2013 · 106 citations · Cited by this paper
  32. Blockage of immune checkpoint molecules increases T‐cell priming potential of dendritic cell vaccine · Hadi Hassannia · 2019 · 103 citations · Cited by this paper
  33. Carboxymethyl chitosan represses tumor angiogenesis in vitro and in vivo · Zhiwen Jiang · 2015 · 102 citations · Cited by this paper
  34. Intratumoral Immunotherapy of Established Solid Tumors With Chitosan/IL-12 · David A. Zaharoff · 2010 · 101 citations · Cited by this paper
  35. Ferroptosis‐Enhanced Immunotherapy with an Injectable Dextran‐Chitosan Hydrogel for the Treatment of Malignant Ascites in Hepatocellular Carcinoma · Jingshu Meng · 2023 · 101 citations · Cited by this paper
  36. Cold to Hot: Binary Cooperative Microneedle Array-Amplified Photoimmunotherapy for Eliciting Antitumor Immunity and the Abscopal Effect · Minglong Chen · 2020 · 100 citations · Cited by this paper
  37. Chitosan/γ-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer · Flávia Damaceno Monteiro de Castro · 2020 · 98 citations · Cited by this paper
  38. Eyedrop-based macromolecular ophthalmic drug delivery for ocular fundus disease treatment · Jingjing Shen · 2023 · 95 citations · Cited by this paper
  39. Blockade of CTLA-4 increases anti-tumor response inducing potential of dendritic cell vaccine · Maryam Esmaily · 2020 · 94 citations · Cited by this paper

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