Research map: The urinary microbiome, overactive bladder and bladder pain syndrome/interstitial cystitis — mechanisms, diagnostics and therapeutic opportunities

Papers in this map

1. The Microbiota-Gut-Brain Axis · John F. Cryan · 2019 · 5234 citations · Cited by this paper
2. Urolithiasis in patients with cancer · 2026 · Related
3. Population-Based Survey of Urinary Incontinence, Overactive Bladder, and Other Lower Urinary Tract Symptoms in Five Countries: Results of the EPIC Study · Debra E. Irwin · 2006 · 2647 citations · Cited by this paper
4. Bladder cancer research is blossoming in Birmingham · 2026 · Related
5. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction · Bernard T. Haylen · 2009 · 2233 citations · Cited by this paper
6. Animal models of spinal cord injury in neuro-urological research · 2026 · Related
7. Urine Is Not Sterile: Use of Enhanced Urine Culture Techniques To Detect Resident Bacterial Flora in the Adult Female Bladder · Evann E. Hilt · 2013 · 896 citations · Cited by this paper
8. Transitional urology: a comprehensive review of the transitional care process · 2026 · Related
9. The Female Urinary Microbiome: a Comparison of Women with and without Urgency Urinary Incontinence · Meghan M. Pearce · 2014 · 771 citations · Cited by this paper
10. Why counting women is not enough: from inclusion to equity in oncology trials · 2026 · Related
11. Evidence of Uncultivated Bacteria in the Adult Female Bladder · Alan J. Wolfe · 2012 · 706 citations · Cited by this paper
12. Polypropylene mesh degradation and systemic disease: biological plausibility is not clinical evidence · 2026 · Related
13. The Clinical Urine Culture: Enhanced Techniques Improve Detection of Clinically Relevant Microorganisms · Travis K. Price · 2016 · 443 citations · Cited by this paper
14. Leveraging generative AI to enhance doctor–patient communication · 2026 · Related
15. A Comprehensive Review of Overactive Bladder Pathophysiology: On the Way to Tailored Treatment · B. Peyronnet · 2019 · 440 citations · Cited by this paper
16. Neoadjuvant intraprostatic immunotherapy for high-risk localized prostate cancer · 2026 · Related
17. Vaginal microbiome transplantation in women with intractable bacterial vaginosis · Ahinoam Lev‐Sagie · 2019 · 424 citations · Cited by this paper
18. Physiologic-microbiome interactions in the pathogenesis of genitourinary syndrome of menopause among menopausal stages · 2025 · Related
19. Network analysis methods for studying microbial communities: A mini review · Monica Steffi Matchado · 2021 · 375 citations · Cited by this paper
20. Exploring promising biomarkers based on pathogenic mechanisms in interstitial cystitis/bladder pain syndrome · 2025 · Related
21. Assessing diversity of the female urine microbiota by high throughput sequencing of 16S rDNA amplicons · Huma A. Siddiqui · 2011 · 346 citations · Cited by this paper
22. Menopause and the vaginal microbiome · Alicia L. Muhleisen · 2016 · 341 citations · Cited by this paper
23. Intravesical bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomised, placebo-controlled, double-blind clinical trial · Lorenz Leitner · 2020 · 330 citations · Cited by this paper
24. The female urinary microbiome in urgency urinary incontinence · Meghan M. Pearce · 2015 · 304 citations · Cited by this paper
25. Does the Urinary Microbiome Play a Role in Urgency Urinary Incontinence and Its Severity? · Lisa A. Karstens · 2016 · 278 citations · Cited by this paper
26. Incontinence medication response relates to the female urinary microbiota · Krystal J. Thomas-White · 2015 · 261 citations · Cited by this paper
27. Alterations of microbiota in urine from women with interstitial cystitis · Huma A. Siddiqui · 2012 · 232 citations · Cited by this paper
28. A standard for terminology in chronic pelvic pain syndromes: A report from the chronic pelvic pain working group of the international continence society · Regula Doggweiler · 2016 · 229 citations · Cited by this paper
29. Persistence and Adherence with Mirabegron versus Antimuscarinic Agents in Patients with Overactive Bladder: A Retrospective Observational Study in UK Clinical Practice · Christopher Reginald Chapple · 2017 · 209 citations · Cited by this paper
30. “Sterile Urine” and the Presence of Bacteria · Alan J. Wolfe · 2015 · 185 citations · Cited by this paper
31. Colonic irritation in the rat sensitizes urinary bladder afferents to mechanical and chemical stimuli: an afferent origin of pelvic organ cross-sensitization · Elena E. Ustinova · 2006 · 137 citations · Cited by this paper
32. Male Bladder Microbiome Relates to Lower Urinary Tract Symptoms · Petar Bajic · 2018 · 133 citations · Cited by this paper
33. Community profiling of the urinary microbiota: considerations for low-biomass samples · Lisa A. Karstens · 2018 · 133 citations · Cited by this paper
34. The female urinary microbiota, urinary health and common urinary disorders · Linda T. Brubaker · 2017 · 131 citations · Cited by this paper
35. Cross‐talk and sensitization of bladder afferent nerves · Elena E. Ustinova · 2009 · 118 citations · Cited by this paper
36. Urinary bacteria in adult women with urgency urinary incontinence · Linda T. Brubaker · 2014 · 117 citations · Cited by this paper
37. Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised, open-label, first part of a two-part phase 2 trial · Paul J. Kim · 2024 · 110 citations · Cited by this paper
38. Organ cross talk modulates pelvic pain · Charles N. Rudick · 2007 · 109 citations · Cited by this paper
39. Assessment of the Lower Urinary Tract Microbiota during Symptom Flare in Women with Urologic Chronic Pelvic Pain Syndrome: A MAPP Network Study · J. Curtis Nickel · 2015 · 108 citations · Cited by this paper

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