Research map: BCAA metabolic reprogramming identifies BCKDK as a therapeutic target in cancer
Back to the article
Papers in this map
Hallmarks of Cancer: The Next Generation
· Douglas Hanahan · 2011 · 67934 citations · Cited by this paper
Advancements in the molecular understanding of major depressive disorder uncovering novel targets with therapeutic promise: focus on recurrence of illness
· 2025 · Related
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
· Matthew G. Vander Heiden · 2009 · 16528 citations · Cited by this paper
Modulating tonic NMDA receptor currents: mechanistic insights into ketamine, esketamine, and dextromethorphan for major depressive disorder and implications for the discovery and development of investigational agents
· 2026 · Related
The Emerging Hallmarks of Cancer Metabolism
· Natalya N. Pavlova · 2016 · 6216 citations · Cited by this paper
Molecular targets in gastric cancer for nanomedicine therapeutics: mechanistic insights and translational progress
· 2026 · Related
Targeting cancer metabolism in the era of precision oncology
· Zachary E. Stine · 2021 · 1243 citations · Cited by this paper
AQP7 suppresses cell stemness and metastasis by targeting Wnt signaling in basal-like breast cancer
· 2026 · Related
Combinatorial drug therapy for cancer in the post-genomic era
· Bissan Al‐Lazikani · 2012 · 1115 citations · Cited by this paper
CDK7 as a New therapeutic target in pancreatic and lung cancer: current evidence and future perspectives
· 2025 · Related
Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy
· Jackie E. Bader · 2020 · 1100 citations · Cited by this paper
Advances in CGRP therapeutic targets for migraine: where do we stand 5 years later?
· 2026 · Related
Branched Chain Amino Acids
· Michael D. Neinast · 2018 · 742 citations · Cited by this paper
Transient receptor potential (TRP) channels: an emerging therapeutic target for the treatment of cardiac hypertrophy
· 2026 · Related
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras -driven cancers
· Jared R. Mayers · 2016 · 606 citations · Cited by this paper
Lipopolysaccharide-targeting treatments for multidrug-resistant Pseudomonas aeruginosa
· 2026 · Related
Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer
· Sharanya Sivanand · 2020 · 509 citations · Cited by this paper
5-FU in combination with PARP inhibitor ABT-888 deregulates MGMT-dependent mismatch repair (MMR) pathway in MMR-proficient colorectal cancer stem cells by modulating MGMT/PARP1/MSH6 complex
· 2026 · Related
Metabolism of Amino Acids in Cancer
· Zhen Cheng Wei · 2021 · 439 citations · Cited by this paper
Unveiling the role of mineralocorticoid receptor antagonists in epilepsy: the intersection of seizures, stress, and neuroinflammation
· 2025 · Related
Target validation using chemical probes
· Mark E. Bunnage · 2013 · 436 citations · Cited by this paper
Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia
· Ayuna Hattori · 2017 · 415 citations · Cited by this paper
The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase
· Phillip James White · 2018 · 375 citations · Cited by this paper
Drug–Target Kinetics in Drug Discovery
· Peter J. Tonge · 2017 · 303 citations · Cited by this paper
Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression
· Russell Erick Ericksen · 2019 · 302 citations · Cited by this paper
Branched-chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole-body Metabolism
· Gagandeep Mann · 2021 · 270 citations · Cited by this paper
BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma
· Jintao Li · 2020 · 263 citations · Cited by this paper
Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells
· Gang Lu · 2009 · 229 citations · Cited by this paper
Rational Cancer Treatment Combinations: An Urgent Clinical Need
· Julia Boshuizen · 2020 · 219 citations · Cited by this paper
Allosteric small-molecule kinase inhibitors
· Peng Wu · 2015 · 217 citations · Cited by this paper
Regulation of branched-chain α-ketoacid dehydrogenase kinase
· Ralph Paxton · 1984 · 179 citations · Cited by this paper
Enzymes involved in branched-chain amino acid metabolism in humans
· María M. Adeva‐Andany · 2017 · 168 citations · Cited by this paper
Branched-chain amino acid catabolism: unique segregation of pathway enzymes in organ systems and peripheral nerves
· Andrew J. Sweatt · 2004 · 146 citations · Cited by this paper
Impaired growth and neurological abnormalities in branched-chain α-keto acid dehydrogenase kinase-deficient mice
· Mandar Joshi · 2006 · 126 citations · Cited by this paper
Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase
· Shih-Chia Tso · 2014 · 115 citations · Cited by this paper
Phenylbutyrate therapy for maple syrup urine disease
· Nicola Brunetti‐Pierri · 2010 · 99 citations · Cited by this paper
BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer
· Peipei Xue · 2017 · 93 citations · Cited by this paper
Designing small molecules to target cryptic pockets yields both positive and negative allosteric modulators
· Kathryn M. Hart · 2017 · 79 citations · Cited by this paper
Inhibition of branched chain alpha-ketoacid dehydrogenase kinase activity by alpha-chloroisocaproate.
· Robert A. Harris · 1982 · 78 citations · Cited by this paper
Source: OpenAlex (CC0)