Research map: Artificial Intelligence-Assisted Prediction and Experimental Assessment of Drug–Excipient Compatibility for Early Formulation Development

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Papers in this map

  1. Artificial intelligence in drug discovery and development · Debleena Paul · 2020 · 1680 citations · Cited by this paper
  2. Quality-by-design Assisted Laboratory Scale Up of Artemisinin Nanoemulsion Augmented Drug Delivery, Cytotoxicity and Cellular Uptake in Leishmania donovani Parasite, a Causative Agent for Cutaneous Leishmaniasis · 2026 · Related
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  9. Artificial intelligence-driven pharmaceutical industry: A paradigm shift in drug discovery, formulation development, manufacturing, quality control, and post-market surveillance · Kampanart Huanbutta · 2024 · 150 citations · Cited by this paper
  10. Self-Assembled Dextran-Stearic Acid Nanocarrier for Co-Delivery of Temozolomide and IFN-α with Enhanced in Vitro Antitumor Activity in Melanoma Cells · 2026 · Related
  11. Pharmaceutical Excipients and Drug Metabolism: A Mini-Review · Rahul Patel · 2020 · 108 citations · Cited by this paper
  12. Synergistic Anticancer effects of Fagonia indica Extract in Combination with Paclitaxel and Benzoporphyrin Derivative · 2026 · Related
  13. Compatibility studies of acyclovir and lactose in physical mixtures and commercial tablets · Farnaz Monajjemzadeh · 2009 · 88 citations · Cited by this paper
  14. Umbilical MSC-Derived Exosome-Associated Standardized Propolis Polyphenols Enhance Apoptosis-Associated and Oxidant-Responsive Signals in HepG2 Cells · 2026 · Related
  15. Influence of artificial intelligence in modern pharmaceutical formulation and drug development · Kazi Asraf Ali · 2024 · 84 citations · Cited by this paper
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  17. Development of Natural Compound Molecular Fingerprint (NC-MFP) with the Dictionary of Natural Products (DNP) for natural product-based drug development · Myungwon Seo · 2020 · 70 citations · Cited by this paper
  18. Mechanistic Insights into LGALS3-Mediated Osteoarthritis Progression: Activation of the cGAS-STING Pathway as a Key Driver of Senescence-Related Osteoarthritis · 2026 · Related
  19. Hierarchical Porous Carbon—PLLA and PLGA Hybrid Nanoparticles for Intranasal Delivery of Galantamine for Alzheimer’s Disease Therapy · Stavroula G. Nanaki · 2020 · 57 citations · Cited by this paper
  20. Box-Behnken Design (BBD) Based Development of Naringenin Encapsulated Transferosome Infused In Situ Gel for Wound Healing: Safety Study, Efficacy Assessment and In Vitro Evaluation · 2026 · Related
  21. Molecular-fingerprint machine-learning-assisted design and prediction for high-performance MOFs for capture of NMHCs from air · Xueying Yuan · 2021 · 51 citations · Cited by this paper
  22. DE-INTERACT: A machine-learning-based predictive tool for the drug-excipient interaction study during product development—Validation through paracetamol and vanillin as a case study · Swayamprakash Patel · 2023 · 38 citations · Cited by this paper
  23. A prediction model based on artificial intelligence techniques for disintegration time and hardness of fast disintegrating tablets in pre-formulation tests · Mehri Momeni · 2024 · 38 citations · Cited by this paper
  24. Preparation, Characterization, and Biological Evaluation of a Hydrophilic Peptide Loaded on PEG-PLGA Nanoparticles · Lisa Marinelli · 2022 · 37 citations · Cited by this paper
  25. Artificial intelligence-driven prediction of multiple drug interactions · Siqi Chen · 2022 · 35 citations · Cited by this paper
  26. Drug-Drug Interactions Prediction Using Fingerprint Only · Bing Ran · 2022 · 33 citations · Cited by this paper
  27. A Review of Machine Learning and QSAR/QSPR Predictions for Complexes of Organic Molecules with Cyclodextrins · Dariusz Boczar · 2024 · 31 citations · Cited by this paper
  28. Towards safer and efficient formulations: Machine learning approaches to predict drug-excipient compatibility · Nguyễn Thu Hằng · 2024 · 29 citations · Cited by this paper
  29. Compatibility of atenolol with excipients: LC–MS/TOF characterization of degradation/interaction products, and mechanisms of their formation · Vijay Kumar · 2009 · 25 citations · Cited by this paper
  30. Drug-Excipient Compatibility Study Through a Novel Vial-in-Vial Experimental Setup: A Benchmark Study · Sonali Jain · 2023 · 24 citations · Cited by this paper
  31. Accelerated Predictive Stability Testing: Accelerating Registration Phase and Application of Reduced Designs for Shelf-Life Determination of Parenteral Drug Product · Lara Pavčnik · 2025 · 24 citations · Cited by this paper
  32. A comprehensive review of the Maillard reaction in solid pharmaceutical dosage forms: a focus on lactose · Jia Xiang · 2026 · 24 citations · Cited by this paper
  33. FTIR, Raman spectroscopy and HT-XRD in compatibility study between naproxen and excipients · Barbara Rojek · 2023 · 21 citations · Cited by this paper
  34. Drug-excipient compatibility studies in formulation development: A case study with benznidazole and monoglycerides · Rodrigo Henrique Saatkamp · 2023 · 19 citations · Cited by this paper
  35. Graph Neural Network-Based Toxicity Prediction by Integrating Molecular Fingerprints and Knowledge Graph Features · Junjie Xie · 2025 · 17 citations · Cited by this paper
  36. A rapid FTIR spectroscopic assay for quantitative determination of Memantine hydrochloride and Amisulpride in human plasma and pharmaceutical formulations · Noha Nahedj Atia · 2020 · 13 citations · Cited by this paper
  37. Molecular Descriptors as a Facile Tool toward Designing Surface-Functionalized Nanoparticles for Drug Delivery · Sourav Bhattacharjee · 2022 · 10 citations · Cited by this paper
  38. Anti-Alzheimer's effect of memantine/donepezil/metformin-loaded PVA/PEO composite nanofibers produced by pressurized gyration: Production, characterization, and in vitro evaluation · Ece Güler · 2024 · 10 citations · Cited by this paper
  39. Preparation and in vitro characterization of memantine HCl loaded PLGA nanoparticles for Alzheimer's disease · Gizem Tezel · 2024 · 10 citations · Cited by this paper

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