Research map: Understanding vial strain during freezing of aqueous solutions–Part I: A combined approach of experimental strain gauge measurements and computer simulations

Back to the article

Papers in this map

  1. Design of Freeze-Drying Processes for Pharmaceuticals: Practical Advice · Xiaolin Charlie Tang · 2004 · 972 citations · Cited by this paper
  2. Formulation development and evaluation of nasal in situ gel of promethazine hydrochloride- part II: Pharmacokinetic evaluation and bioavailability studies · 2026 · Related
  3. Current Perspectives on Stability of Protein Drug Products during Formulation, Fill and Finish Operations · Nitin Rathore · 2008 · 291 citations · Cited by this paper
  4. From particle to performance: Linking size-dependent swelling to disintegration mechanisms in natural plant product tablets · 2026 · Related
  5. Engineering Properties of Fresh-Water Ice · Lorne W. Gold · 1977 · 154 citations · Cited by this paper
  6. Perfluorocarbon–liquid interface culture method enhances mucus production and allows evaluation of drug permeability through the mucus layer · 2026 · Related
  7. Heat transfer in vial lyophilization · Mikael Brűlls · 2002 · 101 citations · Cited by this paper
  8. In-die compressibility as a surrogate for lubrication-induced changes in tabletability · 2026 · Related
  9. Thermal Expansion of Ice · T.R. Butkovich · 1959 · 50 citations · Cited by this paper
  10. Rational design, expression and refolding of a novel bispecific antibody to simultaneously target VEGF-A and Ang-2 for inhibition of angiogenesis · 2026 · Related
  11. Vial breakage during freeze‐drying: Crystallization of sodium chloride in sodium chloride‐sucrose frozen aqueous solutions · Nathaniel Milton · 2007 · 35 citations · Cited by this paper
  12. Efficacy of ultraviolet irradiation of pharmaceutical excipients in mitigating N-nitrosamine generation · 2026 · Related
  13. Stochastic shelf-scale modeling framework for the freezing stage in freeze-drying processes · Leif-Thore Deck · 2021 · 34 citations · Cited by this paper
  14. Elucidation of intermolecular interaction patterns in quaternary solid dispersion complexes of enzalutamide · 2026 · Related
  15. Trouble With the Neighbor During Freeze-Drying: Rivalry About Energy · Sarah Ehlers · 2020 · 29 citations · Cited by this paper
  16. Niclosamide ethanolamine induces malignant phyllodes tumor cell death via mTOR-TFEB axis-mediated lysosomal biogenesis and functional uncoupling · 2026 · Related
  17. Quality attributes and evaluation of pharmaceutical glass containers for parenterals · Charudharshini Srinivasan · 2019 · 27 citations · Cited by this paper
  18. Correlation between protein-polydimethylsiloxane visible particle formation and computationally derived antibody surface properties · 2026 · Related
  19. Thermal Expansion Measurements in Fresh and Saline Ice Using Fiber Optic Strain Gauges and Multipoint Temperature Sensors Based on Bragg Gratings · Aleksey V. Marchenko · 2016 · 25 citations · Cited by this paper
  20. Identification of a diastereomer of penicilloic acid during acid-mediated degradation of 6-aminopenicillanic acid · 2026 · Related
  21. Thermal expansion of substrate may affect adhesion of Chinese hamster fibroblasts to surfaces during freezing · Taylor Rutt · 2018 · 21 citations · Cited by this paper
  22. Experimental measurement and expression of atmospheric ice Young's modulus according to its density · Valérian Palanque · 2023 · 20 citations · Cited by this paper
  23. Thermal Expansion of Single-Crystal H 2 O and D 2 O Ice Ih · David T. W. Buckingham · 2018 · 19 citations · Cited by this paper
  24. Study of Oncolytic Virus Preservation and Formulation · Lina Pan · 2023 · 15 citations · Cited by this paper
  25. Failure of Glass Tubing Vials during Lyophilization · David R. Machak · 2018 · 9 citations · Cited by this paper
  26. Impact of chamber wall temperature on energy transfer during freeze-drying · Sarah Ehlers · 2020 · 9 citations · Cited by this paper
  27. Effects of Subzero Temperature Exposure and Supercooling on Glass Vial Breakage: Risk Management and Other Applications in Cold Chain Distribution · Edgard Chow · 2012 · 8 citations · Cited by this paper
  28. Vial Breakage in Lyophilization- Case Studies from Commercial Manufacturing and Laboratory Studies · Ekneet Kaur Sahni · 2022 · 7 citations · Cited by this paper
  29. Mechanism of glass ampoule breakage prevention during the freeze-drying process of sodium thiopental lyophilization products on addition of sodium chloride · Takuro Ito · 2006 · 6 citations · Cited by this paper
  30. Freeze Drying and Vial Breakage: Misconceptions, Root Causes and Mitigation Strategies for the Pharmaceutical Industry · Xin Jin · 2023 · 6 citations · Cited by this paper
  31. Mechanical Characterization of Vial Strain During Freezing and Thawing Operations Using Amorphous Excipients · Andrew David Strongrich · 2024 · 4 citations · Cited by this paper

Source: OpenAlex (CC0)