Research map: Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics

Back to the article

Papers in this map

  1. Mechanisms and regulation of cholesterol homeostasis · Jie Luo · 2019 · 2069 citations · Cited by this paper
  2. Colorectal Precancerous Lesions: Molecular Mechanisms, Research Tools, and Natural Product‐Based Clinical Translation · 2026 · Related
  3. 27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology · Erik Russell Nelson · 2013 · 861 citations · Cited by this paper
  4. Theranostic Advancements in Brain Cancer: Promising Approaches for Emerging Therapy · 2026 · Related
  5. LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor · Noam Zelcer · 2009 · 859 citations · Cited by this paper
  6. The Role of Glycoprotein Non‐Metastatic Melanoma Protein B (GPNMB) in Tumors and Other Diseases · 2025 · Related
  7. Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol · Su-Yang Liu · 2012 · 701 citations · Cited by this paper
  8. SIRT7 Orchestrates Ligand‐Dependent ERα Signaling Rewiring to Drive Tamoxifen Resistance in ERα‐positive Breast Cancer · 2026 · Related
  9. Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics · Yajun Duan · 2022 · 530 citations · Cited by this paper
  10. A Causal Relationship Between Genetically Proxied Inhibition of HMGCR, NPC1L1, and PCSK9 and Cancers · 2025 · Related
  11. Altered metabolism in cancer: insights into energy pathways and therapeutic targets · Muhammad Tufail · 2024 · 516 citations · Cited by this paper
  12. Interplay between 7-ketocholesterol and tamoxifen shapes stress responses in breast cancer cells · 2026 · Related
  13. Oxysterols direct immune cell migration via EBI2 · Sébastien Hannedouche · 2011 · 501 citations · Cited by this paper
  14. Tumor‐Resident Mast Cells Facilitated Breast Cancer Progression via Activating Type I Interferon Pathway · 2026 · Related
  15. 25-Hydroxycholesterol suppresses interleukin-1–driven inflammation downstream of type I interferon · Andrea Reboldi · 2014 · 451 citations · Cited by this paper
  16. Cancer Comorbidities: Clinical Impacts, Mechanistic Insights, and Management Strategies · 2026 · Related
  17. The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells · Amy E. Baek · 2017 · 442 citations · Cited by this paper
  18. Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery · 2026 · Related
  19. 25-Hydroxycholesterols in innate and adaptive immunity · Jason G. Cyster · 2014 · 399 citations · Cited by this paper
  20. Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity · 2026 · Related
  21. 27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth · Qian Wu · 2013 · 361 citations · Cited by this paper
  22. Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation · Eric V. Dang · 2017 · 361 citations · Cited by this paper
  23. Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer · Wen Liu · 2021 · 355 citations · Cited by this paper
  24. Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages · Sean P. Arlauckas · 2018 · 349 citations · Cited by this paper
  25. Tumor-mediated liver X receptor-α activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses · Eduardo J. Villablanca · 2009 · 338 citations · Cited by this paper
  26. 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production · David R. Bauman · 2009 · 337 citations · Cited by this paper
  27. EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells · Jianhua Li · 2016 · 320 citations · Cited by this paper
  28. Oxysterols are allosteric activators of the oncoprotein Smoothened · Sigrid Nachtergaele · 2012 · 293 citations · Cited by this paper
  29. Phospholipids and cholesterol: Inducers of cancer multidrug resistance and therapeutic targets · Joanna Kopecka · 2019 · 293 citations · Cited by this paper
  30. 25-Hydroxycholesterol acts as an amplifier of inflammatory signaling · Elizabeth S. Gold · 2014 · 257 citations · Cited by this paper
  31. The oxysterol–CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils · Laura Raccosta · 2013 · 245 citations · Cited by this paper
  32. Oxysterol Gradient Generation by Lymphoid Stromal Cells Guides Activated B Cell Movement during Humoral Responses · Tangsheng Yi · 2012 · 233 citations · Cited by this paper
  33. Functional significance of cholesterol metabolism in cancer: from threat to treatment · Mingming Xiao · 2023 · 229 citations · Cited by this paper
  34. The Role of Oxysterols in Human Cancer · Alžběta Spálenková · 2017 · 201 citations · Cited by this paper
  35. Chrysotoxine regulates ferroptosis and the PI3K/AKT/mTOR pathway to prevent cervical cancer · Ji Zhou · 2024 · 187 citations · Cited by this paper
  36. 25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages · Jun Xiao · 2024 · 185 citations · Cited by this paper
  37. Cholesterol oxidation products and their biological importance · Waldemar Kulig · 2016 · 184 citations · Cited by this paper
  38. PI3K/AKT/mTOR signaling pathway: an important driver and therapeutic target in triple-negative breast cancer · Huanping Zhang · 2024 · 182 citations · Cited by this paper
  39. ABCA1 and ABCG1 as potential therapeutic targets for the prevention of atherosclerosis · Michinori Matsuo · 2021 · 177 citations · Cited by this paper

Source: OpenAlex (CC0)