Research map: Febuxostat enhances the anti-tumor efficacy of 2-fluoroadenine and 5’-methylthioadenosine in MTAP-deleted cancer

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  1. Next-generation characterization of the Cancer Cell Line Encyclopedia · Mahmoud Ghandi · 2019 · 3790 citations · Cited by this paper
  2. Chemotherapy-Induced Neutropenia in Palestinian Patients with Solid Malignancies: Patient Characteristics, Severity Risk Factors, and Management Patterns · 2026 · Related
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  15. 5′-Methylthioadenosine administration prevents lipid peroxidation and fibrogenesis induced in rat liver by carbon-tetrachloride intoxication · Maria Maddalena Simile · 2001 · 114 citations · Cited by this paper
  16. BRAF Inhibition–Associated Nuclear Remodeling is Linked to Cancer-Associated Fibroblast Activation · 2026 · Related
  17. Metabolism and Metabolic Actions of 6-Methylpurine and 2-Fluoroadenine in Human Cells · William Bell. Parker · 1998 · 112 citations · Cited by this paper
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  19. 8-Hydroxyadenine as the intermediate in the oxidation of adenine to 2,8-dihydroxyadenine by xanthine oxidase · James Β. Wyngaarden · 1957 · 111 citations · Cited by this paper
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  21. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia · Olufunmilayo Ibironke Olopade · 1992 · 88 citations · Cited by this paper
  22. Assignment of the gene for methylthioadenosine phosphorylase to human chromosome 9 by mouse-human somatic cell hybridization. · Carlos J. Carrera · 1984 · 64 citations · Cited by this paper
  23. The xanthine oxidase inhibitor Febuxostat reduces tissue uric acid content and inhibits injury-induced inflammation in the liver and lung · Hiroshi Kataoka · 2014 · 54 citations · Cited by this paper
  24. The clinical value of serum xanthine oxidase levels in patients with acute ischemic stroke · Hailong Yu · 2023 · 43 citations · Cited by this paper
  25. Specific Targeting of MTAP -Deleted Tumors with a Combination of 2′-Fluoroadenine and 5′-Methylthioadenosine · Baiqing Tang · 2018 · 35 citations · Cited by this paper
  26. Methylthioadenosine phosphorylase deficiency in tumors: A compelling therapeutic target · Na Fan · 2023 · 35 citations · Cited by this paper
  27. Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells · Baiqing Tang · 2012 · 34 citations · Cited by this paper
  28. Differential Neuroprotective Effects of 5′-Deoxy-5′-Methylthioadenosine · Beatriz Moreno · 2014 · 27 citations · Cited by this paper
  29. Regulation of Xanthine Oxidase Activity by Substrates at Active Sites via Cooperative Interactions between Catalytic Subunits: Implication to Drug Pharmacokinetics · Lin Ai Tai · 2010 · 9 citations · Cited by this paper
  30. A systematic literature review of MTAP deletions in solid and hematologic Cancers · Mary C. Clouser · 2025 · 6 citations · Cited by this paper
  31. The efficacy and safety of different doses of febuxostat and allopurinol: A meta-analysis · Feng Zhang · 2025 · 4 citations · Cited by this paper
  32. PRMT5 Identified as a Viable Target for Combination Therapy in Preclinical Models of Pancreatic Cancer · Xiaolong Wei · 2025 · 2 citations · Cited by this paper

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