Research map: cGAS-STING signaling in acute myeloid leukemia: biology, pathophysiology and therapeutic implications

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Papers in this map

  1. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel · Hartmut Döhner · 2016 · 5984 citations · Cited by this paper
  2. Mouse Gata1 3′UTR modulates Gata1 levels to affect erythropoiesis · 2025 · Related
  3. Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion · Haidong Dong · 2002 · 5117 citations · Cited by this paper
  4. The rise of bone marrow organoids as next-generation models for blood formation and failure · 2026 · Related
  5. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade · Yoshiko Iwai · 2002 · 3256 citations · Cited by this paper
  6. Emerging paradigms in redox regulation: the role of selenoproteins in normal and malignant hematopoiesis · 2025 · Related
  7. Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing · Qi Chen · 2016 · 2353 citations · Cited by this paper
  8. Image-enabled cell sorting permits prospective isolation of primitive hematopoietic stem cell subsets with distinct functional potential · 2026 · Related
  9. STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors · Liufu Deng · 2014 · 2194 citations · Cited by this paper
  10. CD20-targeted immunotherapies in B-cell malignancies: mechanistic and clinical advances · 2026 · Related
  11. Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation · Siqi Liu · 2015 · 1983 citations · Cited by this paper
  12. 2019 – ENDOTHELIAL CELL-DERIVED THROMBOSPONDIN-1 NEGATIVELY AFFECTS HEMATOPOIETIC FUNCTION DURING AGING · 2025 · Related
  13. STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors · Seng‐Ryong Woo · 2014 · 1923 citations · Cited by this paper
  14. ER-diffusion barriers exist in hematopoietic stem cell mitoses, but are not required for lysosomal asymmetric cell division · 2025 · Related
  15. Cancer immunoediting and resistance to T cell-based immunotherapy · Jake S. O’Donnell · 2018 · 1826 citations · Cited by this paper
  16. Inhibition of activated protein C anticoagulant function enhances coagulation but does not interrupt downstream mechanisms driving hemophilic arthropathy · 2026 · Related
  17. Cell cycle control in cancer · Helen K. Matthews · 2021 · 1537 citations · Cited by this paper
  18. Cytotoxic and Genotoxic Stress Transiently Increase the Contribution of Platelet-Biased Hematopoietic Stem Cells to Platelet Production · 2026 · Related
  19. Cytoplasmic chromatin triggers inflammation in senescence and cancer · Zhixun Dou · 2017 · 1357 citations · Cited by this paper
  20. Heme synthesis inhibition induces the intrinsic apoptosis pathway in leukemia with OSGIN1 upregulation · 2026 · Related
  21. Mitochondrial DNA in innate immune responses and inflammatory pathology · Andrew Phillip West · 2017 · 1124 citations · Cited by this paper
  22. Structural basis of STING binding with and phosphorylation by TBK1 · Conggang Zhang · 2019 · 1112 citations · Cited by this paper
  23. Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP · Guijun Shang · 2019 · 781 citations · Cited by this paper
  24. Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer · Michael M. Vilenchik · 2003 · 733 citations · Cited by this paper
  25. Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling · Hiroyasu Konno · 2013 · 698 citations · Cited by this paper
  26. Nuclear cGAS suppresses DNA repair and promotes tumorigenesis · Haipeng Liu · 2018 · 673 citations · Cited by this paper
  27. Innate Immune Recognition of Cancer · Seng‐Ryong Woo · 2015 · 592 citations · Cited by this paper
  28. cGAS-STING pathway in cancer biotherapy · Yang Wang · 2020 · 414 citations · Cited by this paper
  29. TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA/STING Protein for K63-linked Ubiquitination · Jing Zhang · 2012 · 410 citations · Cited by this paper
  30. STING cyclic dinucleotide sensing originated in bacteria · Benjamin R. Morehouse · 2020 · 404 citations · Cited by this paper
  31. The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum · Sonal Srikanth · 2018 · 379 citations · Cited by this paper
  32. The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis · Saskia Friederike Erttmann · 2022 · 371 citations · Cited by this paper
  33. Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy · Takahiro Yamazaki · 2020 · 359 citations · Cited by this paper
  34. STING-induced regulatory B cells compromise NK function in cancer immunity · Sirui Li · 2022 · 345 citations · Cited by this paper
  35. Non-cell-autonomous cancer progression from chromosomal instability · Jun Li · 2023 · 312 citations · Cited by this paper
  36. Cytosolic DNA sensing by cGAS: regulation, function, and human diseases · Le Yu · 2021 · 272 citations · Cited by this paper
  37. TRIM29 promotes DNA virus infections by inhibiting innate immune response · Junji Xing · 2017 · 257 citations · Cited by this paper
  38. Phosphorylation and chromatin tethering prevent cGAS activation during mitosis · Tuo Li · 2021 · 238 citations · Cited by this paper
  39. Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity · Pengyan Xia · 2016 · 229 citations · Cited by this paper

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