Research map: Siglec-9: A pivotal immune checkpoint connecting immune homeostasis with the pathogenesis of multiple diseases

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Papers in this map

  1. Interactions between Siglec-7/9 receptors and ligands influence NK cell–dependent tumor immunosurveillance · Camilla Jandus · 2014 · 454 citations · Cited by this paper
  2. LINC01004-SPI1 axis-activated SIGLEC9 in tumor-associated macrophages induces radioresistance and the formation of immunosuppressive tumor microenvironment in esophageal squamous cell carcinoma · Fen qin Zhao · 2023 · 37 citations · Related
  3. Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response · Aaron F. Carlin · 2009 · 409 citations · Cited by this paper
  4. Rewiring immunometabolism in hepato-biliary-pancreatic cancers: Unraveling TME-mediated metabolic suppression and advancing next-generation immunotherapeutic approaches · 2026 · Related
  5. The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins · Stacy Alyse Malaker · 2019 · 300 citations · Cited by this paper
  6. Predicting the course: Real-world trajectories toward minimal disease activity in psoriatic arthritis · 2026 · Related
  7. Siglec-9, a Novel Sialic Acid Binding Member of the Immunoglobulin Superfamily Expressed Broadly on Human Blood Leukocytes · Jiquan Q. Zhang · 2000 · 239 citations · Cited by this paper
  8. The future of TCR-Treg therapies is renewables · 2026 · Related
  9. Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer · Heinz Philipp Laubli · 2014 · 236 citations · Cited by this paper
  10. Pathological reprogramming of innate immune cells drives resistance to biologics in inflammatory bowel diseases · 2026 · Related
  11. Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment · Stephan von Gunten · 2005 · 219 citations · Cited by this paper
  12. Small molecules targeting immune checkpoint proteins for cancer immunotherapy: a patent and literature review (2020–2024) · 2025 · Related
  13. Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes · Jennifer A. Belisle · 2010 · 216 citations · Cited by this paper
  14. Inflammatory biomarkers of atherosclerosis in SLE that may improve SLE-specific cardiovascular risk assessment tools · 2026 · Related
  15. A Small Region of the Natural Killer Cell Receptor, Siglec-7, Is Responsible for Its Preferred Binding to α2,8-Disialyl and Branched α2,6-Sialyl Residues · Toshiyuki Yamaji · 2002 · 210 citations · Cited by this paper
  16. Iron, autoimmunity, and thrombosis: Exploring sex-specific interactions · 2026 · Related
  17. Negative Regulation of T Cell Receptor Signaling by Siglec-7 (p70/AIRM) and Siglec-9 · Yuzuru Ikehara · 2004 · 208 citations · Cited by this paper
  18. The application of low-carbohydrate diet in autoimmune diseases: Mechanisms, evidence, and prospects for clinical translation · 2026 · Related
  19. Targeting Siglecs with a sialic acid–decorated nanoparticle abrogates inflammation · Shaun Spence · 2015 · 185 citations · Cited by this paper
  20. Cell Death Modulation by Intravenous Immunoglobulin · 2010 · Related
  21. Siglecs-7/9 function as inhibitory immune checkpoints in vivo and can be targeted to enhance therapeutic antitumor immunity · Itziar Ibarlucea-Benitez · 2021 · 182 citations · Cited by this paper
  22. The Membrane-Proximal Immunoreceptor Tyrosine-Based Inhibitory Motif Is Critical for the Inhibitory Signaling Mediated by Siglecs-7 and -9, CD33-Related Siglecs Expressed on Human Monocytes and NK Cells · Tony Avril · 2004 · 178 citations · Cited by this paper
  23. Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation? · Huan Cao · 2010 · 171 citations · Cited by this paper
  24. Cloning, Characterization, and Phylogenetic Analysis of Siglec-9, a New Member of the CD33-related Group of Siglecs · Takashi Angata · 2000 · 169 citations · Cited by this paper
  25. Siglec-9 Regulates an Effector Memory CD8+ T-cell Subset That Congregates in the Melanoma Tumor Microenvironment · Quentin Haas · 2019 · 163 citations · Cited by this paper
  26. Secreted Ectodomain of Sialic Acid-Binding Ig-Like Lectin-9 and Monocyte Chemoattractant Protein-1 Promote Recovery after Rat Spinal Cord Injury by Altering Macrophage Polarity · Kohki Matsubara · 2015 · 148 citations · Cited by this paper
  27. Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties · Huifeng Yu · 2017 · 134 citations · Cited by this paper
  28. Immunologic and functional evidence for anti–Siglec-9 autoantibodies in intravenous immunoglobulin preparations · Stephan von Gunten · 2006 · 132 citations · Cited by this paper
  29. High Resolution Crystal Structures of Siglec-7 · M.S. Alphey · 2003 · 129 citations · Cited by this paper
  30. Lectin Galactoside-binding Soluble 3 Binding Protein (LGALS3BP) Is a Tumor-associated Immunomodulatory Ligand for CD33-related Siglecs · Heinz Philipp Laubli · 2014 · 119 citations · Cited by this paper
  31. Siglec-9 enhances IL-10 production in macrophages via tyrosine-based motifs · Munetoshi Ando · 2008 · 110 citations · Cited by this paper
  32. Sugar Free: Novel Immunotherapeutic Approaches Targeting Siglecs and Sialic Acids to Enhance Natural Killer Cell Cytotoxicity Against Cancer · John M. Daly · 2019 · 109 citations · Cited by this paper
  33. Sialoglycoproteins adsorbed by Pseudomonas aeruginosa facilitate their survival by impeding neutrophil extracellular trap through siglec-9 · Biswajit Khatua · 2012 · 106 citations · Cited by this paper
  34. Factors secreted from dental pulp stem cells show multifaceted benefits for treating experimental rheumatoid arthritis · Jun Ishikawa · 2015 · 100 citations · Cited by this paper
  35. Click and Pick: Identification of Sialoside Analogues for Siglec‐Based Cell Targeting · Cory D. Rillahan · 2012 · 98 citations · Cited by this paper
  36. Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment · Hannah Egan · 2023 · 97 citations · Cited by this paper
  37. Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation · Ismael Secundino · 2015 · 94 citations · Cited by this paper
  38. Colonic Epithelial Cells Express Specific Ligands for Mucosal Macrophage Immunosuppressive Receptors Siglec-7 and -9 · Keiko Miyazaki · 2012 · 92 citations · Cited by this paper
  39. Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing · Satoshi Uchiyama · 2019 · 85 citations · Cited by this paper

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