Research map: PAICS as a diagnostic and prognostic biomarker in bladder cancer: bioinformatics and molecular dynamics insights

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  1. Regularization Paths for Generalized Linear Models via Coordinate Descent · Jerome H. Friedman · 2010 · 21057 citations · Cited by this paper
  2. cGAS-STING pathway-related genes as candidate molecules associated with cervical intraepithelial neoplasia: an exploratory bioinformatics analysis · 2026 · Related
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  5. Treatment Options and Outcomes in Nonmetastatic Muscle Invasive Bladder Cancer · Rashed A. Ghandour · 2019 · 142 citations · Cited by this paper
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  7. Role and regulation of coordinately expressedde novopurine biosynthetic enzymesPPATandPAICSin lung cancer · Moloy T. Goswami · 2015 · 116 citations · Cited by this paper
  8. FXYD6 functions as a tumor suppressor in lung adenocarcinoma via the OIP5-AS1/miR-4735-3p/FXYD6 axis · 2026 · Related
  9. Transcriptome sequencing identifies ANLN as a promising prognostic biomarker in bladder urothelial carcinoma · Shuxiong Zeng · 2017 · 75 citations · Cited by this paper
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  11. The Role of the Microbiome in the Etiopathogenesis of Colon Cancer · Geniver El Tekle · 2024 · 68 citations · Cited by this paper
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  13. Machine learning identifies TIME subtypes linking EGFR mutations and immune states in lung adenocarcinoma · Zetian Gong · 2025 · 67 citations · Cited by this paper
  14. Pan-cancer analysis identifies ODF2 as a dual prognostic and predictive biomarker for immunotherapy · 2026 · Related
  15. A Role for De Novo Purine Metabolic Enzyme PAICS in Bladder Cancer Progression · Balabhadrapatruni V. S. K. Chakravarthi · 2018 · 62 citations · Cited by this paper
  16. Ion homeostasis related gene signature characterizes the immune landscape and predicts prognosis in lung adenocarcinoma · 2026 · Related
  17. Metabolic reprogramming signature predicts immunotherapy efficacy in lung adenocarcinoma: Targeting SLC25A1 to overcome immune resistance · Zhang Pengpeng · 2025 · 61 citations · Cited by this paper
  18. The Tumor Microenvironment of Bladder Cancer · Ken Hatogai · 2020 · 61 citations · Cited by this paper
  19. Roles of highly expressed PAICS in lung adenocarcinoma · Shuyi Zhou · 2019 · 56 citations · Cited by this paper
  20. Tumor immune microenvironment (TIME) to enhance antitumor immunity · Sajin Rajbhandary · 2023 · 51 citations · Cited by this paper
  21. Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines · Minjun Meng · 2018 · 50 citations · Cited by this paper
  22. Expression and Role of PAICS, a De Novo Purine Biosynthetic Gene in Prostate Cancer · Balabhadrapatruni V. S. K. Chakravarthi · 2016 · 50 citations · Cited by this paper
  23. Molecular subtypes and prognostic signature rooted in disulfidptosis highlight tumor microenvironment in lung adenocarcinoma · Wei Xia · 2025 · 41 citations · Cited by this paper
  24. Expression of Th1- Th2- and Th17-associated cytokines in laryngeal carcinoma · Xiaoqun Xu · 2016 · 39 citations · Cited by this paper
  25. Identification of Key Biomarkers in Bladder Cancer: Evidence from a Bioinformatics Analysis · Chuan Zhang · 2020 · 36 citations · Cited by this paper
  26. Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy · Chantal Hoi Yin Cheung · 2019 · 35 citations · Cited by this paper
  27. Urinary Exosomal Long Noncoding RNA TERC as a Noninvasive Diagnostic and Prognostic Biomarker for Bladder Urothelial Carcinoma · Chen Chen · 2022 · 34 citations · Cited by this paper
  28. Th17 Cells Induce Th1-Polarizing Monocyte-Derived Dendritic Cells · Matthew G Davidson · 2013 · 31 citations · Cited by this paper
  29. In silico analysis of the immune microenvironment in bladder cancer · Ye Zhang · 2020 · 31 citations · Cited by this paper
  30. PAICS contributes to gastric carcinogenesis and participates in DNA damage response by interacting with histone deacetylase 1/2 · Nan Jing Huang · 2020 · 30 citations · Cited by this paper
  31. Molecular and Pharmacological Bladder Cancer Therapy Screening: Discovery of Clofarabine as a Highly Active Compound · Iris E. Ertl · 2022 · 28 citations · Cited by this paper
  32. Prognosis and immune infiltration analysis of endoplasmic reticulum stress-related genes in bladder urothelial carcinoma · Yaxuan Wang · 2022 · 28 citations · Cited by this paper
  33. Identification of a glutamine metabolism reprogramming signature for predicting prognosis, immunotherapy efficacy, and drug candidates in bladder cancer · Yan Xu · 2023 · 23 citations · Cited by this paper
  34. PAICS as a potential target for cancer therapy linking purine biosynthesis to cancer progression · A. Huo Ma · 2023 · 21 citations · Cited by this paper
  35. PLAUR as a Potential Biomarker Associated with Immune Infiltration in Bladder Urothelial Carcinoma · Mulin Liu · 2021 · 16 citations · Cited by this paper
  36. Genome‐scale CRISPR–Cas9 screen identifies PAICS as a therapeutic target for EGFR wild‐type non‐small cell lung cancer · Yufeng Li · 2024 · 16 citations · Cited by this paper
  37. Do we know the Th1/Th2/Th17 determinants of vaccine response? · Srinivas Garlapati · 2012 · 13 citations · Cited by this paper
  38. Clinical Potential of Fruit in Bladder Cancer Prevention and Treatment · Paulina Wigner · 2022 · 13 citations · Cited by this paper
  39. Core promoter mutation contributes to abnormal gene expression in bladder cancer · Teng Huang · 2022 · 12 citations · Cited by this paper

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