Research map: CRISPR/Cas system as a novel therapeutic strategy to combat multi-drug-resistant bacteria

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  1. A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity · Martin Jínek · 2012 · 17808 citations · Cited by this paper
  2. Lacticaseibacillus paracasei Jlus66 ameliorates hyperuricemia by inhibiting xanthine oxidase activity, modulating uric acid transporter proteins and the gut microbiota · 2026 · Related
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  17. Molecular mechanisms of antibiotic resistance · Jessica M. A. Blair · 2014 · 4116 citations · Cited by this paper
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  21. Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes · Stan J. J. Brouns · 2008 · 2693 citations · Cited by this paper
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  23. An updated evolutionary classification of CRISPR–Cas systems · Kira S. Makarova · 2015 · 2640 citations · Cited by this paper
  24. CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III · Elitza M. Deltcheva · 2011 · 2623 citations · Cited by this paper
  25. Evolution and classification of the CRISPR–Cas systems · Kira S. Makarova · 2011 · 2561 citations · Cited by this paper
  26. Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product · Yoshizumi Ishino · 1987 · 2421 citations · Cited by this paper
  27. The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA · Josiane E. Garneau · 2010 · 2403 citations · Cited by this paper
  28. Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies · Zheng Pang · 2018 · 2374 citations · Cited by this paper
  29. Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements · Francisco J. M. Mojica · 2005 · 2272 citations · Cited by this paper
  30. An overview of the antimicrobial resistance mechanisms of bacteria · Wanda C. Reygaert · 2018 · 1925 citations · Cited by this paper
  31. Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria · Clayton W. Hall · 2017 · 1732 citations · Cited by this paper
  32. The CRISPR tool kit for genome editing and beyond · Mazhar Adli · 2018 · 1706 citations · Cited by this paper
  33. Engineered CRISPR-Cas9 nucleases with altered PAM specificities · Benjamin P. Kleinstiver · 2015 · 1696 citations · Cited by this paper
  34. Emerging Strategies to Combat ESKAPE Pathogens in the Era of Antimicrobial Resistance: A Review · Mansura S. Mulani · 2019 · 1686 citations · Cited by this paper
  35. Evolved Cas9 variants with broad PAM compatibility and high DNA specificity · Johnny H. Hu · 2018 · 1646 citations · Cited by this paper
  36. Structural Mechanism for Rifampicin Inhibition of Bacterial RNA Polymerase · Elizabeth A. Campbell · 2001 · 1601 citations · Cited by this paper
  37. Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and Approaches to Resolve It · Zeinab Breijyeh · 2020 · 1579 citations · Cited by this paper
  38. β-Lactams and β-Lactamase Inhibitors: An Overview · Karen Bush · 2016 · 1370 citations · Cited by this paper
  39. CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies · Christine Pourcel · 2005 · 1369 citations · Cited by this paper

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