Research map: The role of the HB-EGF-regulated EGFR-mitophagy axis in maintaining cartilage homeostasis and osteoarthritis

Back to the article

Papers in this map

  1. EGF–ERBB signalling: towards the systems level · Ami Citri · 2006 · 2031 citations · Cited by this paper
  2. Human chorionic membrane mesenchymal stem cell-conditioned medium activates the SOX18/MECP2 axis to protect against sepsis-induced lung injury · 2026 · Related
  3. Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021 · Jaimie D Steinmetz · 2023 · 2016 citations · Cited by this paper
  4. Arctiin activates CB2R to regulate the TRAF6-STAT1/6 pathway maintain macrophage M1/M2 homeostasis · 2026 · Related
  5. Mechanisms of mitophagy in cellular homeostasis, physiology and pathology · Konstantinos Palikaras · 2018 · 1511 citations · Cited by this paper
  6. Leukemia inhibitory factor drives malignant progression in lung squamous cell carcinoma via the PI3K/AKT/GSK-3β/β-catenin axis · 2026 · Related
  7. Autophagy and Mitophagy in Cardiovascular Disease · José Manuel Bravo‐San Pedro · 2017 · 852 citations · Cited by this paper
  8. Alpha-2-macroglobulin attenuates glucocorticoid-induced osteonecrosis of the femoral head by enhancing osteogenesis and antioxidant defense via the Akt/Nrf2 signaling pathway · 2026 · Related
  9. Deciphering the Molecular Signals of PINK1/Parkin Mitophagy · Thanh Ngoc Nguyen · 2016 · 748 citations · Cited by this paper
  10. Porcine submandibular glands as potential salivary gland experimental models: histological, immunohistochemical, and ultrastructural characterization · 2026 · Related
  11. Intra-articular treatment options for knee osteoarthritis · Ian A. Jones · 2018 · 533 citations · Cited by this paper
  12. Study of the potential protective efficacy of lactoferrin on indomethacin-induced gastric fundic mucosal injury in rats · 2026 · Related
  13. Mitophagy in degenerative joint diseases · Kai Sun · 2020 · 471 citations · Cited by this paper
  14. lncRNA MEG3 and Beclin-1 as diagnostic biomarkers in serous ovarian carcinoma: molecular and immunohistochemical insights · 2026 · Related
  15. Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases · Carlotta Giorgi · 2018 · 465 citations · Cited by this paper
  16. Downregulation of fibroblast growth factor 7 impairs endometrial receptivity and decidualisation via extracellular signal-regulated kinase and C-Jun N-Terminal kinase pathways, contributing to recurrent spontaneous abortion · 2026 · Related
  17. LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis · Manoj Arra · 2020 · 423 citations · Cited by this paper
  18. Testosterone propionate maintains autophagic flux and mitochondrial integrity via regulation of the LC3B/p62/Beclin-1/mTOR axis in induced liver fibrosis · 2026 · Related
  19. PINK1/Parkin-mediated mitophagy in neurodegenerative diseases · Jie Li · 2022 · 383 citations · Cited by this paper
  20. Protective effects of Withania somnifera (Ashwagandha) against chronic unpredictable mild stress-induced testicular damage in adolescent rats · 2026 · Related
  21. Osteoarthritis: the genesis of pain · Kai Fu · 2017 · 345 citations · Cited by this paper
  22. Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis · Eleni Zengini · 2018 · 341 citations · Cited by this paper
  23. Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis · Konstantinos Palikaras · 2015 · 272 citations · Cited by this paper
  24. Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes · Mohammad Y. Ansari · 2017 · 248 citations · Cited by this paper
  25. Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy · Sunli Hu · 2020 · 237 citations · Cited by this paper
  26. Mitochondrial Structure and Bioenergetics in Normal and Disease Conditions · Margherita Protasoni · 2021 · 223 citations · Cited by this paper
  27. Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK/PINK1/Parkin-mediated mitophagy · Zhuangzhuang Jin · 2022 · 191 citations · Cited by this paper
  28. Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis · Davide Francesco D'Amico · 2022 · 169 citations · Cited by this paper
  29. Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy in primary chondrocytes · Chenzhong Wang · 2018 · 167 citations · Cited by this paper
  30. A Systems View of Risk Factors for Knee Osteoarthritis Reveals Insights into the Pathogenesis of the Disease · Thomas P. Andriacchi · 2014 · 141 citations · Cited by this paper
  31. Human Cachexia Induces Changes in Mitochondria, Autophagy and Apoptosis in the Skeletal Muscle · Gabriela Salim de Castro · 2019 · 118 citations · Cited by this paper
  32. EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation · Haoruo Jia · 2016 · 114 citations · Cited by this paper
  33. Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease · Yu-Wen Zhang · 2005 · 97 citations · Cited by this paper
  34. Pink1-Mediated Chondrocytic Mitophagy Contributes to Cartilage Degeneration in Osteoarthritis · Hyo Jung Shin · 2019 · 90 citations · Cited by this paper
  35. Transforming growth factor α suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis · Christopher Thomas Appleton · 2007 · 81 citations · Cited by this paper
  36. Transforming growth factor alpha controls the transition from hypertrophic cartilage to bone during endochondral bone growth · Shirine E. Usmani · 2012 · 72 citations · Cited by this paper
  37. Loading‐Induced Reduction in Sclerostin as a Mechanism of Subchondral Bone Plate Sclerosis in Mouse Knee Joints During Late‐Stage Osteoarthritis · Haoruo Jia · 2017 · 72 citations · Cited by this paper
  38. Mitochondria and mitophagy: biosensors for cartilage degradation and osteoarthritis · Francisco Javier Blanco · 2018 · 63 citations · Cited by this paper
  39. Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation · Ben Staal · 2014 · 58 citations · Cited by this paper

Source: OpenAlex (CC0)