Research map: Metabolic reprogramming of NSUN2-mediated m5C modification promotes the progression of hepatocellular carcinoma by restricting natural killer cell-mediated cytotoxicity

Back to the article

Papers in this map

  1. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries · Freddie Bray · 2024 · 26051 citations · Cited by this paper
  2. In vivo intratumoral heterogeneity in a dish: scalable forebrain organoid models of embryonal brain tumors for high‐throughput personalized drug discovery · 2025 · Related
  3. Metabolic regulation of gene expression by histone lactylation · Di Zhang · 2019 · 4375 citations · Cited by this paper
  4. Anbenitamab in combination with chemotherapy in patients with HER2‐positive gastric or gastroesophageal junction carcinoma who failed previous therapy containing trastuzumab: a multicenter, phase II study (KC‐WISE 01) · 2025 · Related
  5. Combination cancer immunotherapy and new immunomodulatory targets · Kathleen Margaret Mahoney · 2015 · 1346 citations · Cited by this paper
  6. A practical overview and statistical analysis of interval‐censored data in cancer · 2025 · Related
  7. Exploring the NK cell platform for cancer immunotherapy · Jacob A. Myers · 2020 · 1333 citations · Cited by this paper
  8. The Roles of Protein S -Palmitoylation in Cancers: From Dynamic Modulation to Therapeutic Potential · 2026 · Related
  9. 5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader · Xin Yang · 2017 · 1229 citations · Cited by this paper
  10. WTAP-Mediated Glutaminase Splicing Bias Suppresses Ferroptosis in Hepatocellular Carcinoma · 2026 · Related
  11. NK cells and cancer: you can teach innate cells new tricks · Maelig G. Morvan · 2015 · 1182 citations · Cited by this paper
  12. Proliferation and Apoptosis Adaptor Protein 15 (PEA15), a Potential Oncogenic Regulator of VHL and HIF1A Identified through Proteomic Analysis in Hepatocellular Carcinoma · 2026 · Related
  13. Natural killer cells and other innate lymphoid cells in cancer · Laura Chiossone · 2018 · 1043 citations · Cited by this paper
  14. CD24 is a promising immunotherapeutic target for enhancing efficacy of third‐generation EGFR‐TKIs on EGFR‐mutated lung cancer · 2025 · Related
  15. Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade · Joy Hsu · 2018 · 842 citations · Cited by this paper
  16. Neoadjuvant chemoradiotherapy with capecitabine and irinotecan guided by UGT1A1 status in patients with locally advanced rectal cancer: 5‐year update of the CinClare trial · 2025 · Related
  17. The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma · Romain Donné · 2022 · 639 citations · Cited by this paper
  18. HMGB3 promotes brain metastasis of lung adenocarcinoma by recruiting SSBP1 for nuclear translocation to remodel mitochondrial metabolism · 2025 · Related
  19. Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer · Roland Nilsson · 2014 · 622 citations · Cited by this paper
  20. Camrelizumab Plus Nab-paclitaxel in Patients with Previously Treated Advanced Urothelial Carcinoma: A Multicenter Phase II Study · 2026 · Related
  21. Formation and function of the lytic NK-cell immunological synapse · Jordan Scott Orange · 2008 · 610 citations · Cited by this paper
  22. A single-cell atlas of the multicellular ecosystem of primary and metastatic hepatocellular carcinoma · Yiming Lu · 2022 · 555 citations · Cited by this paper
  23. Natural killer cell therapies · Eric D. Vivier · 2024 · 467 citations · Cited by this paper
  24. Lactate and lactylation in cancer · Jie Chen · 2025 · 461 citations · Cited by this paper
  25. NK Cell-Based Immune Checkpoint Inhibition · Muhammad Babar Khan · 2020 · 368 citations · Cited by this paper
  26. Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches · Muhammad Tufail · 2025 · 347 citations · Cited by this paper
  27. CD36+ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor · Guiqi Zhu · 2023 · 342 citations · Cited by this paper
  28. Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma · Alessandra De Leo · 2024 · 311 citations · Cited by this paper
  29. Biological roles of RNA m5C modification and its implications in Cancer immunotherapy · Hang Song · 2022 · 245 citations · Cited by this paper
  30. CD56brightPerforinlow Noncytotoxic Human NK Cells Are Abundant in Both Healthy and Neoplastic Solid Tissues and Recirculate to Secondary Lymphoid Organs via Afferent Lymph · Paolo Carrega · 2014 · 226 citations · Cited by this paper
  31. Moonlighting functions of metabolic enzymes and metabolites in cancer · Chaoyun Pan · 2021 · 203 citations · Cited by this paper
  32. Histone lactylation drives CD8+ T cell metabolism and function · Deblina Raychaudhuri · 2024 · 190 citations · Cited by this paper
  33. Histone Lactylation: A New Role for Glucose Metabolism · Maria V. Liberti · 2019 · 178 citations · Cited by this paper
  34. The role of RNA methylation in tumor immunity and its potential in immunotherapy · Yan Li · 2024 · 150 citations · Cited by this paper
  35. Hepatocellular carcinoma patients with high circulating cytotoxic T cells and intra-tumoral immune signature benefit from pembrolizumab: results from a single-arm phase 2 trial · Jung Yong Hong · 2022 · 140 citations · Cited by this paper
  36. Metabolic Recoding of NSUN2‐Mediated m 5 C Modification Promotes the Progression of Colorectal Cancer via the NSUN2/YBX1/m 5 C‐ENO1 Positive Feedback Loop · Baoxiang Chen · 2024 · 128 citations · Cited by this paper
  37. Multifunctional Effects of a Small-Molecule STAT3 Inhibitor on NASH and Hepatocellular Carcinoma in Mice · Kwang Hwa Jung · 2017 · 126 citations · Cited by this paper
  38. Epigenetically upregulated NSUN2 confers ferroptosis resistance in endometrial cancer via m5C modification of SLC7A11 mRNA · Shuai-Jun Chen · 2023 · 125 citations · Cited by this paper
  39. Tumors evade immune cytotoxicity by altering the surface topology of NK cells · Xiaohu Zheng · 2023 · 117 citations · Cited by this paper

Source: OpenAlex (CC0)