Research map: Risk of developing malignant peripheral nerve sheath tumors in patients with neurofibromatosis 1 receiving MEK inhibitor treatment for plexiform neurofibromas

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  1. Malignant peripheral nerve sheath tumours in neurofibromatosis 1 · D. Gareth Evans · 2002 · 1297 citations · Cited by this paper
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  23. Low mutation burden and frequent loss of CDKN2A/B and SMARCA2, but not PRC2, define premalignant neurofibromatosis type 1–associated atypical neurofibromas · Alexander Pemov · 2019 · 121 citations · Cited by this paper
  24. Tumor Burden in Patients with Neurofibromatosis Types 1 and 2 and Schwannomatosis: Determination on Whole-Body MR Images · Wenli Cai · 2009 · 119 citations · Cited by this paper
  25. A nationwide cohort study on treatment and survival in patients with malignant peripheral nerve sheath tumours · Enrico L. Martin · 2019 · 112 citations · Cited by this paper
  26. ReNeu: A Pivotal, Phase IIb Trial of Mirdametinib in Adults and Children With Symptomatic Neurofibromatosis Type 1-Associated Plexiform Neurofibroma · Christopher L. Moertel · 2024 · 102 citations · Cited by this paper
  27. Longitudinal evaluation of peripheral nerve sheath tumors in neurofibromatosis type 1: growth analysis of plexiform neurofibromas and distinct nodular lesions · Srivandana Akshintala · 2020 · 82 citations · Cited by this paper
  28. Characteristics of children enrolled in treatment trials for NF1-related plexiform neurofibromas · A. Kim · 2009 · 79 citations · Cited by this paper
  29. Benign whole body tumor volume is a risk factor for malignant peripheral nerve sheath tumors in neurofibromatosis type 1 · Rosa Nguyen · 2013 · 74 citations · Cited by this paper
  30. Selumetinib in children with neurofibromatosis type 1 and asymptomatic inoperable plexiform neurofibroma at risk for developing tumor-related morbidity · Andrea M. Gross · 2022 · 70 citations · Cited by this paper
  31. Radiation-Induced Malignant Peripheral Nerve Sheath Tumors: A Systematic Review · Ryuya Yamanaka · 2017 · 69 citations · Cited by this paper
  32. Efficacy and safety of selumetinib in adults with neurofibromatosis type 1 and symptomatic, inoperable plexiform neurofibromas (KOMET): a multicentre, international, randomised, placebo-controlled, parallel, double-blind, phase 3 study · Alice P. Chen · 2025 · 52 citations · Cited by this paper
  33. Selumetinib in adults with NF1 and inoperable plexiform neurofibroma: a phase 2 trial · Andrea M. Gross · 2025 · 50 citations · Cited by this paper
  34. The Role of Polycomb Repressive Complex in Malignant Peripheral Nerve Sheath Tumor · Xiyuan Zhang · 2020 · 42 citations · Cited by this paper
  35. Consensus recommendations for an integrated diagnostic approach to peripheral nerve sheath tumors arising in the setting of Neurofibromatosis Type 1 · Calixto‐Hope G. Lucas · 2024 · 39 citations · Cited by this paper
  36. Sporadic and Familial Variants in NF1: An Explanation of the Wide Variability in Neurocognitive Phenotype? · Maëlle Biotteau · 2020 · 36 citations · Cited by this paper
  37. Non-cytotoxic systemic treatment in malignant peripheral nerve sheath tumors (MPNST): A systematic review from bench to bedside · Enrico L. Martin · 2019 · 34 citations · Cited by this paper
  38. Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis: Impact of Family History · Fatema Malbari · 2018 · 20 citations · Cited by this paper
  39. Cellular radiosensitivity of patients with different types of neurofibromatosis · Mohammed A. Hannan · 1993 · 16 citations · Cited by this paper

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