Research map: Cholesterol nose-to-brain delivery as a possible therapeutic strategy in Huntington’s disease

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Papers in this map

  1. Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice · Laura Mangiarini · 1996 · 3117 citations · Cited by this paper
  2. Cholesterol restores corticostriatal synaptic connectivity in Huntington’s disease through BDNF/TrkB signalling, supporting a role for cholesterol pathways implicated by human genetic modifier studies · Allegra Lenci · 2026 · Cites this paper
  3. Application of the Allen Human Brain Atlas in Alzheimer’s disease and Parkinson’s disease · 2026 · Related
  4. Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain · Marian DiFiglia · 1997 · 2933 citations · Cited by this paper
  5. Nanotechnological and in vivo characterization of a new generation of brain-permeable nanoparticles for brain-targeted cholesterol delivery in Huntington’s disease · Giulia Birolini · 2026 · Cites this paper
  6. Age-dependent removal of Atg9-containing vesicle accumulations in motoneuron disease models by physical exercise · 2025 · Related
  7. Thematic review series: Brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal · John M. Dietschy · 2004 · 1095 citations · Cited by this paper
  8. Reduced synaptic vesicle protein 2A in extracellular vesicles and brains of Alzheimer’s disease: associations with Aβ, tau, synaptic proteins and APOE ε4 · 2025 · Related
  9. Linking lipids to Alzheimer's disease: cholesterol and beyond · Gilbert Di Paolo · 2011 · 1000 citations · Cited by this paper
  10. Targeting the glymphatic system: Aβ accumulation and phototherapy strategies across different stages of Alzheimer’s disease · 2025 · Related
  11. Lipid Rafts in the Maintenance of Synapses, Dendritic Spines, and Surface AMPA Receptor Stability · Heike Hering · 2003 · 602 citations · Cited by this paper
  12. Attenuating α-synuclein pathology in mice with in situ engineered astrocytes · 2025 · Related
  13. Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood–brain barrier: an excellent platform for brain targeting · Chandrakantsing Vijaysing Pardeshi · 2013 · 479 citations · Cited by this paper
  14. Stratification of brain-derived extracellular vesicles of Alzheimer’s disease patients indicates a unique proteomic content and a higher seeding capacity of small extracellular vesicles · 2025 · Related
  15. Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain · Ingemar Björkhem · 2006 · 384 citations · Cited by this paper
  16. LRRK2 G2019S mutation contributes to mitochondrial transfer dysfunction in a Drp1-STX17-dependent manner · 2025 · Related
  17. Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis · Lauren M. Byrne · 2017 · 372 citations · Cited by this paper
  18. Proximity labeling in neuroscience: decoding molecular landscapes for precision neurology · 2026 · Related
  19. Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain · David W. Russell · 2009 · 337 citations · Cited by this paper
  20. Microbiota and Alzheimer’s disease: mechanistic insights from a multi-organ perspective · 2026 · Related
  21. Role of cholesterol in synapse formation and function · Frank W. Pfrieger · 2003 · 330 citations · Cited by this paper
  22. Lysophagy protects against ANXA11 amyloid fibril toxicity and propagation in FTLD · 2026 · Related
  23. Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies · Cláudia Pina Costa · 2021 · 303 citations · Cited by this paper
  24. Dysfunction of the Cholesterol Biosynthetic Pathway in Huntington's Disease · Marta Valenza · 2005 · 302 citations · Cited by this paper
  25. Nose-to-brain delivery of lipid-based nanosystems for epileptic seizures and anxiety crisis · Cláudia Pina Costa · 2019 · 208 citations · Cited by this paper
  26. CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease · Lydie Boussicault · 2016 · 197 citations · Cited by this paper
  27. Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse · Gang Quan · 2003 · 178 citations · Cited by this paper
  28. Altered cholesterol and fatty acid metabolism in Huntington disease · Robert Block · 2009 · 156 citations · Cited by this paper
  29. Revisiting nanoparticle technology for blood–brain barrier transport: Unfolding at the endothelial gate improves the fate of transferrin receptor-targeted liposomes · Kasper Bendix Johnsen · 2015 · 131 citations · Cited by this paper
  30. Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation · Marta Valenza · 2007 · 130 citations · Cited by this paper
  31. Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington’s disease · Marta Valenza · 2007 · 127 citations · Cited by this paper
  32. CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington’s disease · Radhia Kacher · 2019 · 118 citations · Cited by this paper
  33. Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington’s disease · Filipe Brogueira Rodrigues · 2020 · 114 citations · Cited by this paper
  34. Cholesterol‐loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice · Marta Valenza · 2015 · 113 citations · Cited by this paper
  35. Oxysterol research: a brief review · William James Griffiths · 2019 · 107 citations · Cited by this paper
  36. Cerebrospinal Fluid Biomarkers for Huntington’s Disease · Lauren M. Byrne · 2016 · 81 citations · Cited by this paper
  37. Cholesterol Hydroxylating Cytochrome P450 46A1: From Mechanisms of Action to Clinical Applications · Irina A. Pikuleva · 2021 · 80 citations · Cited by this paper
  38. Visualizing Cholesterol in the Brain by On-Tissue Derivatization and Quantitative Mass Spectrometry Imaging · Roberto Angelini · 2021 · 74 citations · Cited by this paper
  39. Altered Cholesterol Homeostasis in Huntington’s Disease · Radhia Kacher · 2022 · 67 citations · Cited by this paper

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