Research map: The Impact of Ageing on Skeletal Muscle: Roles of Mitochondrial Dysregulation, Systemic Communication, and Exercise

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  1. Mutation of the mouse klotho gene leads to a syndrome resembling ageing · Makoto Kuro‐o · 1997 · 3883 citations · Cited by this paper
  2. Maternal Obesity Programs Adipogenic Commitment in Neonatal Mesenchymal Stem Cells: A Link to Redox‐Dependent FOXO1 Signaling · 2026 · Related
  3. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders · Darren J. Baker · 2011 · 3748 citations · Cited by this paper
  4. Connexin Regulation and Modulation of Neural Stem Cell Differentiation Induced by Cell‐Permeable Itaconate · 2026 · Related
  5. Cellular senescence: from physiology to pathology · Daniel Muñoz‐Espín · 2014 · 2902 citations · Cited by this paper
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  7. Naturally occurring p16Ink4a-positive cells shorten healthy lifespan · Darren J. Baker · 2016 · 2881 citations · Cited by this paper
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  9. Senolytics improve physical function and increase lifespan in old age · Ming Xu · 2018 · 2357 citations · Cited by this paper
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  11. What is the cause of the ageing atrophy? · Jan E. Lexell · 1988 · 2083 citations · Cited by this paper
  12. Hematopoietic Stem Cell Tropism Mediated Targeting of Breast Cancer Stem Cells via Alteration of Tumor Immune‐Microenvironment · 2026 · Related
  13. Sarcopenia: Aging-Related Loss of Muscle Mass and Function · Lars Larsson · 2018 · 1821 citations · Cited by this paper
  14. Induction of Cellular Senescence by Pesticide Exposure in Human Umbilical Vein Endothelial Cells (HUVECs): Impacts on Telomerase Length, Cellular Morphology, and mtDNA Variation · 2026 · Related
  15. Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis · Aaron W. Joe · 2010 · 1742 citations · Cited by this paper
  16. Role of Chitinase 3–like‐1 in Myelofibrosis via Fibroblast‐Produced Extracellular Matrix Enhancement · 2026 · Related
  17. Strength, But Not Muscle Mass, Is Associated With Mortality in the Health, Aging and Body Composition Study Cohort · Anne B. Newman · 2006 · 1714 citations · Cited by this paper
  18. Neuromuscular electrical stimulation training induces myonuclear accretion and hypertrophy in mice without overt signs of muscle damage and regeneration · 2025 · Related
  19. Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis · Andrew S. Brack · 2007 · 1583 citations · Cited by this paper
  20. Sarcopenia in Menopausal Women: Prevalence, Risk Factors, Hormonal Mechanisms, and Management Strategies · 2025 · Related
  21. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease · Brian N. Finck · 2006 · 1443 citations · Cited by this paper
  22. Inflammation and aging: signaling pathways and intervention therapies · Xia Li · 2023 · 1415 citations · Cited by this paper
  23. Sarcopenia, Dynapenia, and the Impact of Advancing Age on Human Skeletal Muscle Size and Strength; a Quantitative Review · William Kyle Mitchell · 2012 · 1396 citations · Cited by this paper
  24. Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle · Akiyoshi Uezumi · 2010 · 1360 citations · Cited by this paper
  25. Autophagy Is Required to Maintain Muscle Mass · Eva Masiero · 2009 · 1294 citations · Cited by this paper
  26. Notch-Mediated Restoration of Regenerative Potential to Aged Muscle · Irina M. Conboy · 2003 · 1130 citations · Cited by this paper
  27. The role of mitochondria in aging · Ana M. Bratić · 2013 · 1115 citations · Cited by this paper
  28. CXCR3 ligands: redundant, collaborative and antagonistic functions · Joanna R. Groom · 2011 · 1046 citations · Cited by this paper
  29. PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription · Marco Sandri · 2006 · 976 citations · Cited by this paper
  30. Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration · Ramkumar Sambasivan · 2011 · 952 citations · Cited by this paper
  31. Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage · Frédéric Relaix · 2012 · 923 citations · Cited by this paper
  32. The Regulation of Notch Signaling Controls Satellite Cell Activation and Cell Fate Determination in Postnatal Myogenesis · Irina M. Conboy · 2002 · 901 citations · Cited by this paper
  33. The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans · Daniel James Wilkinson · 2018 · 888 citations · Cited by this paper
  34. The aged niche disrupts muscle stem cell quiescence · Joe V. Chakkalakal · 2012 · 871 citations · Cited by this paper
  35. Transcriptional integration of mitochondrial biogenesis · Richard C. Scarpulla · 2012 · 809 citations · Cited by this paper
  36. AGE‐RELATED CHANGES IN THE STRUCTURE AND FUNCTION OF SKELETAL MUSCLES · John A. Faulkner · 2007 · 769 citations · Cited by this paper
  37. Macrophages in inflammation, repair and regeneration · Yumiko Oishi · 2018 · 757 citations · Cited by this paper
  38. Grip strength, body composition, and mortality · Catharine R. Galé · 2006 · 748 citations · Cited by this paper
  39. Rejuvenation of the muscle stem cell population restores strength to injured aged muscles · Benjamin D. Cosgrove · 2014 · 693 citations · Cited by this paper

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