Research map: Vitamin C as an Adjunctive Therapy in Cancer

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Papers in this map

  1. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues · Qi Chen · 2005 · 1084 citations · Cited by this paper
  2. Rising Pancreatic Adenocarcinoma and Type 2 Diabetes Mellitus-Related Mortality in the United States, 2000 to 2024, With Forecasts to 2034 · 2026 · Related
  3. Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer. · Ewan M. Cameron · 1976 · 709 citations · Cited by this paper
  4. Local Control Outcomes of Patients With Brain Metastases From Small Cell Lung Cancer Treated With Stereotactic Radiosurgery · 2026 · Related
  5. Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo · Qi Chen · 2007 · 672 citations · Cited by this paper
  6. Early Versus Delayed Pancreatic Enzyme Replacement Therapy After Pancreatic Cancer Surgery · 2026 · Related
  7. High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy · Yan Ma · 2014 · 495 citations · Cited by this paper
  8. Targeted CysLTR1 Blockade Rescues Myeloid-Mediated Resistance to Immune Checkpoint Inhibition in Solid Malignancies · 2026 · Related
  9. The orthomolecular treatment of cancer II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer · Ewan M. Cameron · 1974 · 344 citations · Cited by this paper
  10. Emergence of Single-Week Adjuvant Radiation Therapy for Early-Stage Breast Cancer in the United States · 2026 · Related
  11. Mechanisms of Ascorbate-Induced Cytotoxicity in Pancreatic Cancer · Juan Du · 2010 · 324 citations · Cited by this paper
  12. The Inpatient Metastatic Spine Score · 2026 · Related
  13. Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial · Jessemae L. Welsh · 2013 · 310 citations · Cited by this paper
  14. Comorbidity Burden, Treatment, and Survival Among Screen-Detected Lung Cancer Patients · 2026 · Related
  15. Phase I Evaluation of Intravenous Ascorbic Acid in Combination with Gemcitabine and Erlotinib in Patients with Metastatic Pancreatic Cancer · Daniel Monti · 2012 · 273 citations · Cited by this paper
  16. Combination of Ponatinib and Blinatumomab in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia · 2026 · Related
  17. High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer · Franziska Böttger · 2021 · 211 citations · Cited by this paper
  18. Disparities in the Receipt of Palliative-Intent Treatment Among Disaggregated Hispanic Populations With Stage IV Liver Cancer in the United States · 2026 · Related
  19. Antioxidant Therapy in Cancer: Rationale and Progress · Maochao Luo · 2022 · 193 citations · Cited by this paper
  20. Executive Summary of the American Radium Society (ARS) Appropriate Use Criteria (AUC) for the Use of Radiation in the Prevention and Treatment of Heterotopic Ossification (HO) · 2026 · Related
  21. Changes of Terminal Cancer Patients' Health-related Quality of Life after High Dose Vitamin C Administration · Chang Hwan Yeom · 2007 · 149 citations · Cited by this paper
  22. High Dose Parenteral Ascorbate Inhibited Pancreatic Cancer Growth and Metastasis: Mechanisms and a Phase I/IIa study · Kishore Polireddy · 2017 · 149 citations · Cited by this paper
  23. The Use of Antioxidants with First-Line Chemotherapy in Two Cases of Ovarian Cancer · Jeanne Drisko · 2003 · 148 citations · Cited by this paper
  24. Pharmacologic Ascorbate Reduces Radiation-Induced Normal Tissue Toxicity and Enhances Tumor Radiosensitization in Pancreatic Cancer · Matthew S. Alexander · 2018 · 128 citations · Cited by this paper
  25. A Phase I/II Study of Arsenic Trioxide/Bortezomib/Ascorbic Acid Combination Therapy for the Treatment of Relapsed or Refractory Multiple Myeloma · James R. Berenson · 2007 · 124 citations · Cited by this paper
  26. Reprogramming the Epigenome With Vitamin C · Taylor Lee Chong · 2019 · 123 citations · Cited by this paper
  27. Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent · Neil H Riordan · 1995 · 118 citations · Cited by this paper
  28. Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells · James C. Boyer · 2005 · 113 citations · Cited by this paper
  29. The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia · Huihui Zhao · 2018 · 111 citations · Cited by this paper
  30. Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs · Anja Frömberg · 2010 · 91 citations · Cited by this paper
  31. Chemotherapy Alonevs.Chemotherapy Plus High Dose Multiple Antioxidants in Patients with Advanced Non Small Cell Lung Cancer · Ashutosh Pathak · 2005 · 90 citations · Cited by this paper
  32. Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes · Linn Gillberg · 2019 · 88 citations · Cited by this paper
  33. First-in-Human Phase I Clinical Trial of Pharmacologic Ascorbate Combined with Radiation and Temozolomide for Newly Diagnosed Glioblastoma · Bryan G. Allen · 2019 · 84 citations · Cited by this paper
  34. Evaluation of the In Vitro and In Vivo Antitumor Activities of Vitamin C and K-3 Combinations against Human Prostate Cancer · James M. Jamison · 2001 · 80 citations · Cited by this paper
  35. Clinical experience with intravenous administration of ascorbic acid: achievable levels in blood for different states of inflammation and disease in cancer patients · Nina A. Mikirova · 2013 · 80 citations · Cited by this paper
  36. Gender and Sodium-Ascorbate Transporter Isoforms Determine Ascorbate Concentrations in Mice · Shiu‐Ming Kuo · 2004 · 77 citations · Cited by this paper
  37. A phase 2 trial exploring the effects of high‐dose (10,000 IU/day) vitamin D3 in breast cancer patients with bone metastases · Eitan Amir · 2009 · 74 citations · Cited by this paper
  38. Sodium Ascorbate induces apoptosis in neuroblastoma cell lines by interfering with iron uptake · Roberta Carosio · 2007 · 71 citations · Cited by this paper
  39. A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy · Basir U. Tareen · 2008 · 67 citations · Cited by this paper

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