Research map: The co-regulation of NLRP3 inflammasome and autophagy for cardiovascular diseases

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Papers in this map

  1. The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation · Nathan Kelley · 2019 · 3590 citations · Cited by this paper
  2. Nephroprotective Effects of Curcumin in Murine Models of Focal and Segmental Glomerulosclerosis · 2025 · Related
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  11. NLRP3 and pyroptosis blockers for treating inflammatory diseases · Rebecca C. Coll · 2022 · 789 citations · Cited by this paper
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  13. Machinery, regulation and pathophysiological implications of autophagosome maturation · Yan G. Zhao · 2021 · 579 citations · Cited by this paper
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  15. Targeting Mitochondria-Inflammation Circuit by β-Hydroxybutyrate Mitigates HFpEF · Yan Deng · 2020 · 416 citations · Cited by this paper
  16. The Effects and Mechanisms of Indole Derivatives in Improving Doxorubicin-Induced Cardiomyopathy · 2025 · Related
  17. Autophagy and Inflammation · Yu Matsuzawa · 2017 · 389 citations · Cited by this paper
  18. Inflammatory conditions determine glucocorticoid effects on spontaneous or immunoglobulin-induced neutrophil death · 2026 · Related
  19. The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy · Patrick Kwabena Oduro · 2021 · 340 citations · Cited by this paper
  20. The role of galectins in the regulation of autophagy and inflammasome in host immunity · 2024 · Related
  21. Targeting the NLRP3 inflammasome in cardiovascular diseases · Stefano A Toldo · 2021 · 329 citations · Cited by this paper
  22. Why should autophagic flux be assessed? · Xiao-Jie Zhang · 2013 · 315 citations · Cited by this paper
  23. NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation · Liudmila Andreeva · 2021 · 292 citations · Cited by this paper
  24. Empagliflozin Blunts Worsening Cardiac Dysfunction Associated With Reduced NLRP3 (Nucleotide-Binding Domain-Like Receptor Protein 3) Inflammasome Activation in Heart Failure · Nikole J. Byrne · 2020 · 267 citations · Cited by this paper
  25. Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome Inhibition · Sai Ma · 2018 · 244 citations · Cited by this paper
  26. Clinical benefits and pharmacology of scutellarin: A comprehensive review · Liping Wang · 2018 · 236 citations · Cited by this paper
  27. Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway · Shaohong Fang · 2021 · 232 citations · Cited by this paper
  28. USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy · Tao Liu · 2020 · 230 citations · Cited by this paper
  29. NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload · Yasutomi Higashikuni · 2022 · 224 citations · Cited by this paper
  30. Macrophage–NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension · Ruaa Al‐Qazazi · 2022 · 222 citations · Cited by this paper
  31. NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice · Fabiola Marín‐Aguilar · 2019 · 219 citations · Cited by this paper
  32. Effect of empagliflozin on circulating proteomics in heart failure: mechanistic insights into the EMPEROR programme · Faiez M. Zannad · 2022 · 219 citations · Cited by this paper
  33. Tetramethylpyrazine: A review on its mechanisms and functions · Jianguo Lin · 2022 · 213 citations · Cited by this paper
  34. Deficient Chaperone-Mediated Autophagy Promotes Inflammation and Atherosclerosis · Lei Qiao · 2021 · 186 citations · Cited by this paper
  35. The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors · Xiaoyan Zhan · 2023 · 181 citations · Cited by this paper
  36. LAMP2A, LAMP2B and LAMP2C: similar structures, divergent roles · Lei Qiao · 2023 · 171 citations · Cited by this paper
  37. Targeting the Inflammasome in Cardiovascular Disease · Maria Belland Olsen · 2021 · 170 citations · Cited by this paper
  38. Irisin protects against vascular calcification by activating autophagy and inhibiting NLRP3-mediated vascular smooth muscle cell pyroptosis in chronic kidney disease · Qi Pang · 2022 · 163 citations · Cited by this paper
  39. Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis · Xiaoxiao Liu · 2022 · 157 citations · Cited by this paper

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