Research map: Regulation of Cochlear Nucleus Synaptogenesis by Progranulin in a Stem Cell–Based Coculture Model

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  1. Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival · Philip Van Damme · 2008 · 423 citations · Cited by this paper
  2. Evaluation of Puromycin-Induced Podocyte Injury and Protective Effects of Voclosporin Using Induced Pluripotent Stem Cells from a Patient with Nephrotic Syndrome Harboring an INF2 Variant · 2026 · Related
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  5. Cellular Localization of Gene Expression for Progranulin · RACHAEL L. DANIEL · 2000 · 356 citations · Cited by this paper
  6. Three-Dimensional Aggregate Culture Enhances the Therapeutic Efficacy of Human Umbilical Cord-Derived Mesenchymal Stem Cells in the Mouse Model of Metabolic Dysfunction-Associated Steatohepatitis · 2026 · Related
  7. Mouse in red: Red fluorescent protein expression in mouse ES cells, embryos, and adult animals · Kristina Vintersten · 2004 · 323 citations · Cited by this paper
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  9. Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system · Charles Petitpré · 2018 · 280 citations · Cited by this paper
  10. Retraction: Transcriptional Repression of Mad-Max Complex by Human Umbilical Cord Blood Stem Cells Downregulates Extracellular Signal-Regulated Kinase in Glioblastoma · 2026 · Related
  11. Progranulin, lysosomal regulation and neurodegenerative disease · Aimee W. Kao · 2017 · 279 citations · Cited by this paper
  12. Efficacy of Thrice-Weekly Versus Once-Weekly Umbilical Cord Mesenchymal Stromal Cell Infusions for Steroid-Refractory Severe Acute Graft-Versus-Host Disease: A Retrospective Cohort Study · 2026 · Related
  13. Synaptic dysfunction in progranulin-deficient mice · Terri L. Petkau · 2011 · 182 citations · Cited by this paper
  14. Effects of Complex I Inhibition on the Architecture of Neural Rosettes Differentiated from Human-Induced Pluripotent Stem Cells · 2025 · Related
  15. Progranulin: normal function and role in neurodegeneration · Jason L. Eriksen · 2007 · 145 citations · Cited by this paper
  16. Basement Membrane of Hertwig’s Epithelial Root Sheath Is Involved in Dental Follicle Cell Differentiation into Cementoblasts · 2025 · Related
  17. Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease · Babykumari P. Chitramuthu · 2017 · 144 citations · Cited by this paper
  18. Engineering of functional auditory neurons from human induced pluripotent stem cells · 2026 · Related
  19. Primary Neural Degeneration in Noise-Exposed Human Cochleas: Correlations with Outer Hair Cell Loss and Word-Discrimination Scores · Pei‐zhe Wu · 2021 · 137 citations · Cited by this paper
  20. Age-related loss of spiral ganglion neurons · Jianxin Bao · 2009 · 131 citations · Cited by this paper
  21. BMP4 induction of sensory neurons from human embryonic stem cells and reinnervation of sensory epithelium · Fuxin Shi · 2007 · 129 citations · Cited by this paper
  22. Translating animal models to human therapeutics in noise-induced and age-related hearing loss · Sharon G. Kujawa · 2019 · 111 citations · Cited by this paper
  23. Audiological issues and hearing loss among veterans with mild traumatic brain injury · Michael Oleksiak · 2012 · 103 citations · Cited by this paper
  24. Auditory difficulties in blast-exposed Veterans with clinically normal hearing · Gabrielle H. Saunders · 2015 · 98 citations · Cited by this paper
  25. Progranulin Deficiency Decreases Gross Neural Connectivity But Enhances Transmission at Individual Synapses · Lucı́a Tapia · 2011 · 88 citations · Cited by this paper
  26. Increased caspase activation and decreased TDP‐43 solubility in progranulin knockout cortical cultures · Gernot Kleinberger · 2010 · 69 citations · Cited by this paper
  27. Autophagy Regulates the Survival of Hair Cells and Spiral Ganglion Neurons in Cases of Noise, Ototoxic Drug, and Age-Induced Sensorineural Hearing Loss · Lingna Guo · 2021 · 66 citations · Cited by this paper
  28. Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease · Jackalina M. Van Kampen · 2017 · 49 citations · Cited by this paper
  29. Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum · Naofumi Uesaka · 2018 · 48 citations · Cited by this paper
  30. Biased auditory nerve central synaptopathy is associated with age‐related hearing loss · Meijian Wang · 2021 · 47 citations · Cited by this paper
  31. Synaptic transmission at the endbulb of Held deteriorates during age‐related hearing loss · Ruili Xie · 2016 · 45 citations · Cited by this paper
  32. Hidden hearing loss and endbulbs of Held: Evidence for central pathology before detection of ABR threshold increases · Michael A. Muniak · 2018 · 45 citations · Cited by this paper
  33. Specification of neuronal subtypes in the spiral ganglion begins prior to birth in the mouse · Tessa R. Sanders · 2022 · 45 citations · Cited by this paper
  34. Potential of embryonic stem cell‐derived neurons for synapse formation with auditory hair cells · Masahiro Matsumoto · 2008 · 44 citations · Cited by this paper
  35. Mechanism and Prevention of Spiral Ganglion Neuron Degeneration in the Cochlea · Li Zhang · 2022 · 42 citations · Cited by this paper
  36. Hidden hearing loss: Fifteen years at a glance · Jiayue Liu · 2024 · 41 citations · Cited by this paper
  37. Loss of Neuroprotective Factors in Neurodegenerative Dementias: The End or the Starting Point? · Luisa Benussi · 2017 · 33 citations · Cited by this paper
  38. Differentiation of Spiral Ganglion-Derived Neural Stem Cells into Functional Synaptogenetic Neurons · Xiaoyang Li · 2016 · 27 citations · Cited by this paper
  39. Innervation of Cochlear Hair Cells by Human Induced Pluripotent Stem Cell‐Derived Neurons In Vitro · Niliksha Gunewardene · 2016 · 26 citations · Cited by this paper

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