Research map: A mini review of genome-predicted β-lactam susceptibility in Streptococcus pneumoniae: from PBP profiles to potential clinical interpretation

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Papers in this map

  1. Setting and Revising Antibacterial Susceptibility Breakpoints · John D. Turnidge · 2007 · 578 citations · Cited by this paper
  2. Functional analyses of male-specific early-phosphorylated proteins reveal an intrinsically disordered protein required for microgamete release in Plasmodium berghei · 2026 · Related
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  5. International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact · Rebecca Ashley Gladstone · 2019 · 284 citations · Cited by this paper
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  7. Penicillin-binding proteins 2b and 2x of Streptococcus pneumoniae are primary resistance determinants for different classes of beta-lactam antibiotics · T Grebe · 1996 · 246 citations · Cited by this paper
  8. Cooperation of transposable elements to endow global networks of initiators of hybrid assembly pathways of endogenous multiprotein complexes · 2026 · Related
  9. Penicillin-Binding Protein Transpeptidase Signatures for Tracking and Predicting β-Lactam Resistance Levels in Streptococcus pneumoniae · Yuan Li · 2016 · 191 citations · Cited by this paper
  10. Longitudinal dynamics and treatment-associated determinants of interferon-gamma responses in tuberculosis: a 10-year retrospective QuantiFERON-TB Gold study · 2026 · Related
  11. Rationale for Revised Penicillin Susceptibility Breakpoints versusStreptococcus pneumoniae:Coping with Antimicrobial Susceptibility in an Era of Resistance · Melvin P. Weinstein · 2009 · 178 citations · Cited by this paper
  12. Diagnostic and differential diagnostic value of plasma extracellular vesicle-associated miRNAs in AIDS patients with tuberculosis and non-tuberculous mycobacterial infection · 2026 · Related
  13. Using whole genome sequencing to identify resistance determinants and predict antimicrobial resistance phenotypes for year 2015 invasive pneumococcal disease isolates recovered in the United States · Benjamin J. Metcalf · 2016 · 145 citations · Cited by this paper
  14. Lipid metabolism in the resuscitation of dormant mycobacterium tuberculosis: molecular resilience, host hijacking, and clinical opportunities · 2026 · Related
  15. Validation of β-lactam minimum inhibitory concentration predictions for pneumococcal isolates with newly encountered penicillin binding protein (PBP) sequences · on behalf of the Active Bacterial Core surveillance team · 2017 · 95 citations · Cited by this paper
  16. Admission CD4+ T cell BTLA expression and its association with infection risk and respiratory outcomes in sepsis · 2026 · Related
  17. Compensatory Evolution of pbp Mutations Restores the Fitness Cost Imposed by β-Lactam Resistance in Streptococcus pneumoniae · Andrea G. Albarracín Orio · 2011 · 87 citations · Cited by this paper
  18. Prevalence and genetic diversity of respiratory syncytial viruses circulating in Bulgaria, 2023-2025 · 2026 · Related
  19. Genomics for antimicrobial resistance—progress and future directions · Norelle L. Sherry · 2025 · 68 citations · Cited by this paper
  20. The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci · Joshua C D'Aeth · 2021 · 48 citations · Cited by this paper
  21. Evidence review and recommendations for the implementation of genomics for antimicrobial resistance surveillance: reports from an international expert group · Kate S. Baker · 2023 · 44 citations · Cited by this paper
  22. Streptococcus pneumoniae serotypes that frequently colonise the human nasopharynx are common recipients of penicillin-binding protein gene fragments from Streptococcus mitis · Akuzike Kalizang’oma · 2021 · 26 citations · Cited by this paper
  23. Genomic analysis and reconstruction of cefotaxime resistance in Streptococcus pneumoniae · Fereshteh Fani · 2013 · 25 citations · Cited by this paper
  24. The acquisition of clinically relevant amoxicillin resistance in Streptococcus pneumoniae requires ordered horizontal gene transfer of four loci · Paddy S. Gibson · 2022 · 25 citations · Cited by this paper
  25. Loss of Pde1 function acts as an evolutionary gateway to penicillin resistance in Streptococcus pneumoniae · Carolin Martina Kobras · 2023 · 25 citations · Cited by this paper
  26. In silico exploration of phenolics as modulators of penicillin binding protein (PBP) 2× of Streptococcus pneumoniae · ‪Jamiu Olaseni Aribisala · 2024 · 21 citations · Cited by this paper
  27. Linear Regression Equations To Predict β-Lactam, Macrolide, Lincosamide, and Fluoroquinolone MICs from Molecular Antimicrobial Resistance Determinants in Streptococcus pneumoniae · Walter Demczuk · 2021 · 19 citations · Cited by this paper
  28. Interspecies recombination, not de novo mutation, maintains virulence after β-lactam resistance acquisition in Streptococcus pneumoniae · Andrew T. Nishimoto · 2022 · 17 citations · Cited by this paper
  29. Development of the Pneumococcal Genome Library, a core genome multilocus sequence typing scheme, and a taxonomic life identification number barcoding system to investigate and define pneumococcal population structure · Melissa J. Jansen van Rensburg · 2024 · 17 citations · Cited by this paper
  30. Systematic analysis of supervised machine learning as an effective approach to predicate β-lactam resistance phenotype in Streptococcus pneumoniae · Chaodong Zhang · 2019 · 16 citations · Cited by this paper
  31. Penicillin susceptibility breakpoints for Streptococcus pneumoniae and their effect on susceptibility categorisation in Germany (1997–2013) · Matthias Imöhl · 2014 · 16 citations · Cited by this paper
  32. Expanded profiling of β-lactam selectivity for penicillin-binding proteins in Streptococcus pneumoniae D39 · Deepti Sharan · 2022 · 15 citations · Cited by this paper
  33. Combined Structural Analysis and Molecular Dynamics Reveal Penicillin-Binding Protein Inhibition Mode with β-Lactones · Parker L. Flanders · 2022 · 14 citations · Cited by this paper
  34. Predicting Oral Beta-lactam susceptibilities against Streptococcus pneumoniae · Mark E. Murphy · 2021 · 13 citations · Cited by this paper
  35. Antimicrobial susceptibility testing of invasive isolates of Streptococcus pneumoniae from Canadian patients: the SAVE study, 2011–2020 · Morgan A. Alford · 2023 · 10 citations · Cited by this paper
  36. Predicting β-lactam susceptibility from the genome of Streptococcus pneumoniae and other mitis group streptococci · Helle Brander Eriksen · 2023 · 8 citations · Cited by this paper
  37. GPS Pipeline: portable, scalable genomic pipeline for Streptococcus pneumoniae surveillance from Global Pneumococcal Sequencing Project · Harry C. H. Hung · 2025 · 8 citations · Cited by this paper
  38. Variability of β-lactam susceptibility testing for Streptococcus pneumoniae using 4 commercial test methods and broth microdilution · Marthe Charles · 2015 · 7 citations · Cited by this paper
  39. The role of whole genome sequencing in antimicrobial susceptibility prediction of bacteria: 2025 update from the European Committee on Antimicrobial Susceptibility Testing Subcommittee · Ørjan Samuelsen · 2026 · 5 citations · Cited by this paper

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