Research map: Beyond Traditional Covariates: An Interpretable Machine Learning Workflow for Improved Hybrid Pharmacometric Modeling

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  1. PhysioBank, PhysioToolkit, and PhysioNet · Ary L. Goldberger · 2000 · 14916 citations · Cited by this paper
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  21. Hospitalized Patients With and Without Hemodialysis Have Markedly Different Vancomycin Pharmacokinetics: A Population Pharmacokinetic Model-Based Analysis · Vineet Goti · 2018 · 84 citations · Cited by this paper
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  24. Pharmacokinetics of vancomycin and dosing recommendations for trauma patients · Susanna Edith Medellín‐Garibay · 2015 · 61 citations · Cited by this paper
  25. Adoption of Machine Learning in Pharmacometrics: An Overview of Recent Implementations and Their Considerations · Alexander Janßen · 2022 · 56 citations · Cited by this paper
  26. Covariate modeling in pharmacometrics: General points for consideration · Kinjal Sanghavi · 2024 · 47 citations · Cited by this paper
  27. Efficient and relevant stepwise covariate model building for pharmacometrics · Robin J. Svensson · 2022 · 45 citations · Cited by this paper
  28. Easy and reliable maximum a posteriori Bayesian estimation of pharmacokinetic parameters with the open‐source R package mapbayr · Félicien Le Louedec · 2021 · 38 citations · Cited by this paper
  29. Application of SHAP values for inferring the optimal functional form of covariates in pharmacokinetic modeling · Alexander Janßen · 2022 · 38 citations · Cited by this paper
  30. Deep compartment models: A deep learning approach for the reliable prediction of time‐series data in pharmacokinetic modeling · Alexander Janßen · 2022 · 37 citations · Cited by this paper
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  33. Application of machine learning combined with population pharmacokinetics to improve individual prediction of vancomycin clearance in simulated adult patients · Guodong Li · 2024 · 15 citations · Cited by this paper
  34. Vancomycin in ICU Patients with Gram-Positive Infections: Initial Trough Levels and Mortality · Nadiyah Alshehri · 2020 · 13 citations · Cited by this paper
  35. Covariate Model Selection Approaches for Population Pharmacokinetics: A Systematic Review of Existing Methods, From SCM to AI · Mélanie Karlsen · 2025 · 12 citations · Cited by this paper
  36. Genetic algorithm guided population pharmacokinetic model development for simvastatin, concurrently or non-concurrently co-administered with amlodipine · Ayyappa Chaturvedula · 2013 · 11 citations · Cited by this paper
  37. Properties of the full random‐effect modeling approach with missing covariate data · Joakim Nyberg · 2023 · 9 citations · Cited by this paper
  38. A Generative and Causal Pharmacokinetic Model for Factor VIII in Hemophilia A: A Machine Learning Framework for Continuous Model Refinement · Alexander Janßen · 2024 · 9 citations · Cited by this paper
  39. Simulation of Vancomycin Exposure Using Trough and Peak Levels Achieves the Target Area under the Steady-State Concentration–Time Curve in ICU Patients · Yuta Ibe · 2023 · 8 citations · Cited by this paper

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