Research map: Multifaceted roles of CD44 in cancer progression and targeted therapeutic strategies

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  1. Prospective identification of tumorigenic breast cancer cells · Muhammad Al‐Hajj · 2003 · 10470 citations · Cited by this paper
  2. CD44 promotes angiogenesis in myocardial infarction through regulating plasma exosome uptake and further enhancing FGFR2 signaling transduction · 2025 · Related
  3. CD44 is the principal cell surface receptor for hyaluronate · Alejandro A. Aruffo · 1990 · 2472 citations · Cited by this paper
  4. METTL14-dependent N6-methyladenosine modification of FGF16 participates in IGFBP5 deficiency-enhanced angiogenesis · 2026 · Related
  5. Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells · Margherita Norelli · 2018 · 1419 citations · Cited by this paper
  6. Decoding spontaneous intracerebral hemorrhage: mechanistic breakthroughs and disruptive revolution in pharmacological treatment · 2026 · Related
  7. FIBRONECTIN AND ITS RECEPTORS · Erkki I. Ruoslahti · 1988 · 1342 citations · Cited by this paper
  8. Metastasis-related genomic aberrations and evolutionary trajectory in uveal melanoma · 2026 · Related
  9. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. · Gavin Robert Screaton · 1992 · 1042 citations · Cited by this paper
  10. Coordinated DNA 5-mC and RNA m5C methylation epigenetically regulates MZF1 splice variants to drive EGFR-TKI resistance · 2026 · Related
  11. Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1) · Georg F. Weber · 1996 · 960 citations · Cited by this paper
  12. Cannabidiol triggers fatty acids β-oxidation mediated by Stat2 to facilitate intestinal stem cells regeneration post radiation · 2026 · Related
  13. Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer · Suniti Misra · 2015 · 884 citations · Cited by this paper
  14. RUNX1 recruitment of GCN5 in keratinocytes upregulates ICOSLG and promotes T cell activation in the psoriasis microenvironment · 2026 · Related
  15. Membrane-Type 1 Matrix Metalloproteinase Cleaves Cd44 and Promotes Cell Migration · Masahiro Kajita · 2001 · 744 citations · Cited by this paper
  16. Dynamics, function, and regulation of mammary stem cells in development and disease · 2026 · Related
  17. Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique alpha and common beta subunits. · Elizabeth A. Wayner · 1987 · 719 citations · Cited by this paper
  18. CPT1B K321 crotonylation contributes to cardiac dysfunction in endotoxic shock · 2026 · Related
  19. Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion · Qin Yu · 1999 · 715 citations · Cited by this paper
  20. Safety, biodistribution, pharmacokinetics, and immunogenicity of 99m Tc-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with squamous cell carcinoma of the head and neck · 2003 · Related
  21. CD44 cell adhesion molecules. · Steve Goodison · 1999 · 682 citations · Cited by this paper
  22. CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression · Rhonda L. Brown · 2011 · 662 citations · Cited by this paper
  23. CD44 is of Functional Importance for Colorectal Cancer Stem Cells · Lei Du · 2008 · 599 citations · Cited by this paper
  24. Hyaluronan-binding Proteins: Tying Up the Giant · Anthony J. Day · 2002 · 578 citations · Cited by this paper
  25. Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth · Alexander Pietras · 2014 · 570 citations · Cited by this paper
  26. A human lymphocyte homing receptor, the Hermes antigen, is related to cartilage proteoglycan core and link proteins · Leslie A. Goldstein · 1989 · 564 citations · Cited by this paper
  27. Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin. · Sirpa Jalkanen · 1992 · 537 citations · Cited by this paper
  28. Non-Small Cell Lung Cancer Cells Expressing CD44 Are Enriched for Stem Cell-Like Properties · Elaine Lai‐Han Leung · 2010 · 482 citations · Cited by this paper
  29. Six Genes Expressed in Bones and Teeth Encode the Current Members of the SIBLING Family of Proteins · Larry W. Fisher · 2003 · 463 citations · Cited by this paper
  30. Hyaluronan biology: A complex balancing act of structure, function, location and context · Stavros Garantziotis · 2019 · 398 citations · Cited by this paper
  31. Characterization of the class III collagen receptor, a phosphorylated, transmembrane glycoprotein expressed in nucleated human cells. · W G Carter · 1988 · 376 citations · Cited by this paper
  32. Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway · Isamu Okamoto · 2001 · 375 citations · Cited by this paper
  33. CD44 variant exon epitopes in primary breast cancer and length of survival · Marwan Kaufmann · 1995 · 362 citations · Cited by this paper
  34. The normal structure and function of CD44 and its role in neoplasia · Robert Sneath · 1998 · 342 citations · Cited by this paper
  35. CD44 directs membrane‐type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin‐like domain · Hidetoshi Mori · 2002 · 338 citations · Cited by this paper
  36. Antimitotic Activity of the Potent Tumor Inhibitor Maytansine · Stephen P. Remillard · 1975 · 335 citations · Cited by this paper
  37. A Phase I Dose Escalation Study with Anti-CD44v6 Bivatuzumab Mertansine in Patients with Incurable Squamous Cell Carcinoma of the Head and Neck or Esophagus · Bernard M. Tijink · 2006 · 325 citations · Cited by this paper
  38. Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins · Jan Willem Mulder · 1994 · 316 citations · Cited by this paper
  39. A Distinct Endothelial Cell Recognition System That Controls Lymphocyte Traffic into Inflamed Synovium · Sirpa Jalkanen · 1986 · 313 citations · Cited by this paper

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