Research map: Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

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Papers in this map

  1. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021 · Kanyin Liane Ong · 2023 · 4687 citations · Cited by this paper
  2. Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management · 2026 · Related
  3. Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes · Jennifer B. Green · 2015 · 2619 citations · Cited by this paper
  4. Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle · 2025 · Related
  5. Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial · Jean‐Louis Chiasson · 2002 · 2560 citations · Cited by this paper
  6. Preoperative Albumin Infusion Reduced Pulmonary Complications in Elderly Patients With Hypoalbuminemia Undergoing Cardiac Surgery: A Single‐Center, Randomized, Double‐Blind, Controlled Pilot Trial · 2026 · Related
  7. Insulin resistance, cardiovascular stiffening and cardiovascular disease · Michael A. Hill · 2021 · 1111 citations · Cited by this paper
  8. CD8 + Tissue‐Resident Memory T Cells in Health and Disease · 2026 · Related
  9. Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial · Julio Rosenstock · 2021 · 1060 citations · Cited by this paper
  10. MYC in Oncogenesis and Therapeutic Implications · 2026 · Related
  11. Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials · Colin Baigent · 2022 · 1023 citations · Cited by this paper
  12. Lymphatic Endothelial Cells in Health and Disease · 2026 · Related
  13. Obesity Management in Adults · Arielle Elmaleh-Sachs · 2023 · 738 citations · Cited by this paper
  14. Nicotinamide N‐Methyltransferase Epigenetically Activates Fibronectin 1 Through H3K9me3 Remodeling in Clear Cell Renal Cell Carcinoma · 2026 · Related
  15. The aetiology and molecular landscape of insulin resistance · David Ernest James · 2021 · 713 citations · Cited by this paper
  16. Markers Predicting Cure With Combinatorial Treatment in a Mouse Model of Latent Autoimmune Diabetes in Adults · 2026 · Related
  17. Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy · Xi Lu · 2024 · 642 citations · Cited by this paper
  18. Dimethyl fumarate modulates M1/M2 macrophage polarization to ameliorate periodontal destruction by increasing TUFM-mediated mitophagy · 2025 · Related
  19. SGLT2 inhibitors and GLP-1 receptor agonists: established and emerging indications · Emily E. Brown · 2021 · 582 citations · Cited by this paper
  20. Islet Tissue Macrophages in Immunity Homeostasis and Type 1 Diabetes · 2025 · Related
  21. A global view of the interplay between non-alcoholic fatty liver disease and diabetes · Norbert Stefan · 2022 · 562 citations · Cited by this paper
  22. Emerging Targets in Type 2 Diabetes and Diabetic Complications · Sevgican Demir · 2021 · 530 citations · Cited by this paper
  23. Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus · Daniel Ferguson · 2021 · 513 citations · Cited by this paper
  24. GLP-1 Receptor Agonists for the Reduction of Atherosclerotic Cardiovascular Risk in Patients With Type 2 Diabetes · Nikolaus Marx · 2022 · 494 citations · Cited by this paper
  25. The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia · Lykke Sylow · 2021 · 354 citations · Cited by this paper
  26. Effects of GLP-1 receptor agonists on kidney and cardiovascular disease outcomes: a meta-analysis of randomised controlled trials · Sunil V. Badve · 2024 · 332 citations · Cited by this paper
  27. MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice · Wei Ying · 2021 · 306 citations · Cited by this paper
  28. Treatment of type 2 diabetes: challenges, hopes, and anticipated successes · Michael Albrecht Nauck · 2021 · 295 citations · Cited by this paper
  29. High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance · Anil Kumar · 2021 · 283 citations · Cited by this paper
  30. Finerenone Reduces Risk of Incident Heart Failure in Patients With Chronic Kidney Disease and Type 2 Diabetes: Analyses From the FIGARO-DKD Trial · Gerasimos Filippatos · 2021 · 283 citations · Cited by this paper
  31. Long-Term Outcomes of Medical Management vs Bariatric Surgery in Type 2 Diabetes · Anita P. Courcoulas · 2024 · 278 citations · Cited by this paper
  32. Hepatic selective insulin resistance at the intersection of insulin signaling and metabolic dysfunction-associated steatotic liver disease · Tao Bo · 2024 · 273 citations · Cited by this paper
  33. Inter-organ crosstalk during development and progression of type 2 diabetes mellitus · Georgia Xourafa · 2023 · 269 citations · Cited by this paper
  34. Pharmacological treatment of hyperglycemia in type 2 diabetes · Simeon I. Taylor · 2021 · 252 citations · Cited by this paper
  35. Insulin resistance and insulin sensitizing agents · Lucia Mastrototaro · 2021 · 252 citations · Cited by this paper
  36. Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care · Nicolas J. Pillon · 2021 · 237 citations · Cited by this paper
  37. Brain insulin signalling in metabolic homeostasis and disease · Thomas Scherer · 2021 · 220 citations · Cited by this paper
  38. Cardiovascular disease in diabetes, beyond glucose · Robert H. Eckel · 2021 · 219 citations · Cited by this paper
  39. The metabolic impact of small intestinal nutrient sensing · Frank Anthony Duca · 2021 · 206 citations · Cited by this paper

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