Research map: FGF21/sirtuin 1 axis mediates the cardioprotective effects of high‐intensity interval training against doxorubicin‐induced cardiotoxicity by reducing inflammatory and oxidative stress

Back to the article

Papers in this map

  1. Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart · Ralph R. Alcendor · 2007 · 1154 citations · Cited by this paper
  2. Digital N ‐of‐1 trials and their application in experimental physiology · 2026 · Related
  3. Understanding the Physiology of FGF21 · ffolliott Martin Fisher · 2015 · 916 citations · Cited by this paper
  4. Effects of 14 days of head‐down bed rest with or without exercise, and subsequent recovery on bone turnover, density and structure in older adults · 2026 · Related
  5. Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management · Pushkar Singh Rawat · 2021 · 910 citations · Cited by this paper
  6. Maternal obesity during lactation as a hypertensive cardiovascular risk factor in the offspring · 2026 · Related
  7. AMPK: positive and negative regulation, and its role in whole-body energy homeostasis · David Grahame Hardie · 2014 · 486 citations · Cited by this paper
  8. Why reporting requires more than findings · 2026 · Related
  9. Running speed and maximal oxygen uptake in rats and mice: practical implications for exercise training · Morten A. Høydal · 2007 · 346 citations · Cited by this paper
  10. When is a muscle at rest? The problem of background activity in brain stimulation · 2026 · Related
  11. Fibroblast growth factor 21 protects the heart from oxidative stress · Anna Planavila · 2014 · 272 citations · Cited by this paper
  12. Long‐term adverse cardiovascular changes induced by cocoa shell extract administration through lactation in fetal undernourished and control rats · 2026 · Related
  13. FGF21–Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity · Leigang Jin · 2022 · 258 citations · Cited by this paper
  14. From hot tub to high altitude: The makings of a human physiology field expedition and the next generation of physiologists · 2026 · Related
  15. Fibroblast growth factor 21 (FGF21) inhibits macrophage-mediated inflammation by activating Nrf2 and suppressing the NF-κB signaling pathway · Yin-Hang Yu · 2016 · 177 citations · Cited by this paper
  16. Effects of baclofen and lorazepam on interhemispheric inhibition in humans · 2026 · Related
  17. FGF21-based pharmacotherapy – potential utility for metabolic disorders · Ruth E. Gimeno · 2014 · 168 citations · Cited by this paper
  18. Jumping in simulated lunar gravity with blood flow restriction as a potential exercise countermeasure: The acute physiological effects · 2026 · Related
  19. Cardioprotective effects of fibroblast growth factor 21 against doxorubicin-induced toxicity via the SIRT1/LKB1/AMPK pathway · Shudong Wang · 2017 · 140 citations · Cited by this paper
  20. Comparison of exercise training and repeated hot water immersion on vascular function in overweight older adults · 2026 · Related
  21. Targeting FGF21 in cardiovascular and metabolic diseases: from mechanism to medicine · Huiling Tan · 2022 · 118 citations · Cited by this paper
  22. Doxorubicin-induced cardiotoxicity and risk factors · Carl W. Belger · 2023 · 109 citations · Cited by this paper
  23. Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2 · Jie Wang · 2022 · 100 citations · Cited by this paper
  24. Mitochondria and Doxorubicin-Induced Cardiomyopathy: A Complex Interplay · Leonardo Schirone · 2022 · 94 citations · Cited by this paper
  25. Doxorubicin cardiomyopathy is ameliorated by acacetin via Sirt1‐mediated activation of AMPK/Nrf2 signal molecules · Wei‐Yin Wu · 2020 · 65 citations · Cited by this paper
  26. Fibroblast Growth Factor 21 (FGF21) Promotes Formation of Aerobic Myofibers via the FGF21‐SIRT1‐AMPK‐PGC1α Pathway · Xinyi Liu · 2016 · 55 citations · Cited by this paper
  27. Rush to the fire: FGF21 extinguishes metabolic stress, metaflammation and tissue damage · Yongde Luo · 2017 · 54 citations · Cited by this paper
  28. Impact of high-intensity interval training and sprint interval training on peripheral markers of glycemic control in metabolic syndrome and type 2 diabetes · Alberto Jiménez‐Maldonado · 2020 · 46 citations · Cited by this paper
  29. Cardioprotective effects of exercise training on doxorubicin-induced cardiomyopathy: a systematic review with meta-analysis of preclinical studies · Paola Victória da Costa Ghignatti · 2021 · 46 citations · Cited by this paper
  30. Targeting necroptotic cell death pathway by high-intensity interval training (HIIT) decreases development of post-ischemic adverse remodelling after myocardial ischemia / reperfusion injury · Alireza Ghardashi Afousi · 2018 · 39 citations · Cited by this paper
  31. Effect of high-intensity interval training on cardiac structure and function in rats with acute myocardial infarct · Bozhong Wang · 2020 · 28 citations · Cited by this paper
  32. The Roles of FGF21 and ALCAT1 in Aerobic Exercise‐Induced Cardioprotection of Postmyocardial Infarction Mice · Wenyan Bo · 2021 · 27 citations · Cited by this paper
  33. The effects of 12 weeks of high-intensity interval training and moderate-intensity continuous training on FGF21, irisin, and myostatin in men with type 2 diabetes mellitus · Simin Riahy · 2023 · 24 citations · Cited by this paper
  34. Cardioprotective effects of asiaticoside against diabetic cardiomyopathy: Activation of the AMPK/Nrf2 pathway · Chennian Xu · 2023 · 23 citations · Cited by this paper
  35. Optimizing dose selection for doxorubicin-induced cardiotoxicity in mice: A comprehensive analysis of single and multiple-dose regimens · Li Min · 2025 · 14 citations · Cited by this paper
  36. Prevention and treatment of anthracycline-induced cardiotoxicity: a systematic review and network meta-analysis of randomized controlled trials · Siyu Li · 2025 · 9 citations · Cited by this paper
  37. High-intensity interval training elicits superior effects than continuous training to improve renal redox status via klotho and Nrf2 signaling in female rats with cisplatin nephrotoxicity · Érika Azenathe Barros Mercês · 2025 · 4 citations · Cited by this paper

Source: OpenAlex (CC0)