Research map: Dual-Metal Regulation of Cardiac Remodeling: Targeting the LOXL2-Ferroptosis Axis in Metal-Induced Cardiac Dysfunction

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  1. Copper induces cell death by targeting lipoylated TCA cycle proteins · Peter Tsvetkov · 2022 · 5027 citations · Cited by this paper
  2. Non-canonical PPARα Agonism by Arjunolic Acid Mitigates Cardiomyocyte PANoptosis Through a Novel PPARα/CRYAB/IKKα Axis During Pathological Cardiac Hypertrophy · 2026 · Related
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  11. Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation · Yoshihiko Ichikawa · 2014 · 897 citations · Cited by this paper
  12. GLI1 Promotes Hypoxia Induced Pyroptosis of PASMCs and Aggravates Pulmonary Arterial Hypertension in Rats by Upregulating HDAC1 Expression · 2026 · Related
  13. Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis · Xuexian Fang · 2020 · 800 citations · Cited by this paper
  14. E-cigarette Aerosol Containing Nicotine Increases Aortic Stiffness in Young Mice · 2026 · Related
  15. Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases · Yi Yu · 2021 · 793 citations · Cited by this paper
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  17. The release and activity of HMGB1 in ferroptosis · Qirong Wen · 2019 · 676 citations · Cited by this paper
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  19. Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity · Tomonori Tadokoro · 2020 · 670 citations · Cited by this paper
  20. Global, Regional, and National Burden of Cardiovascular Diseases and Risk Factors in 204 Countries and Territories, 1990-2023 · Benjamin A. Stark · 2025 · 612 citations · Cited by this paper
  21. Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting Cardiomyocyte Ferroptosis · Wenbin Cai · 2023 · 452 citations · Cited by this paper
  22. Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk between Ferroptosis and Apoptosis · Young‐Sun Lee · 2018 · 444 citations · Cited by this paper
  23. The Role of NCOA4-Mediated Ferritinophagy in Health and Disease · Naiara Santana-Codina · 2018 · 394 citations · Cited by this paper
  24. Lipid Metabolism and Ferroptosis · Ji-Yoon Lee · 2021 · 376 citations · Cited by this paper
  25. Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway · Su-Ran Li · 2022 · 368 citations · Cited by this paper
  26. Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment · Jin Yang · 2016 · 279 citations · Cited by this paper
  27. Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling · Zhenzhou Zhang · 2022 · 263 citations · Cited by this paper
  28. ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis · Vinit Shanbhag · 2019 · 237 citations · Cited by this paper
  29. Dexrazoxane · Risto S Cvetkovi · 2005 · 204 citations · Cited by this paper
  30. TGF-β and WNT signaling pathways in cardiac fibrosis: non-coding RNAs come into focus · Fatemeh Yousefi · 2020 · 198 citations · Cited by this paper
  31. Copper transporters and copper chaperones: roles in cardiovascular physiology and disease · Tohru Fukai · 2018 · 194 citations · Cited by this paper
  32. Iron and Copper in Mitochondrial Diseases · Wenjing Xu · 2013 · 185 citations · Cited by this paper
  33. Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling · Tetyana G Voloshenyuk · 2011 · 179 citations · Cited by this paper
  34. In defence of ferroptosis · Francesca M. Alves · 2025 · 176 citations · Cited by this paper
  35. The Molecular Mechanisms of Iron Metabolism and Its Role in Cardiac Dysfunction and Cardioprotection · T Ravíngerová · 2020 · 165 citations · Cited by this paper
  36. Cardiac 12/15 lipoxygenase–induced inflammation is involved in heart failure · Yosuke Kayama · 2009 · 157 citations · Cited by this paper
  37. Iron Metabolism in Cardiovascular Disease: Physiology, Mechanisms, and Therapeutic Targets · Konrad Teodor Sawicki · 2023 · 152 citations · Cited by this paper
  38. Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction · José González · 2015 · 144 citations · Cited by this paper
  39. Targeting Iron Metabolism and Ferroptosis as Novel Therapeutic Approaches in Cardiovascular Diseases · Yufei Andy Chen · 2023 · 139 citations · Cited by this paper

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