Research map: Beyond randomized clinical trials in pediatric rheumatology: exploring the potential of target trial emulation

Back to the article

Papers in this map

  1. Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies · Erik B von Elm · 2007 · 10808 citations · Cited by this paper
  2. Decoding the complexity of intestinal immunity with spatial transcriptomics · 2026 · Related
  3. Using Big Data to Emulate a Target Trial When a Randomized Trial Is Not Available: Table 1. · Miguel Ángel Hernán · 2016 · 3061 citations · Cited by this paper
  4. Understanding antiphospholipid syndrome clinical phenotypes with the guidance of antiphospholipid antibody-related pathogenic mechanisms · 2026 · Related
  5. Immortal Time Bias in Pharmacoepidemiology · Samy Suissa · 2007 · 1793 citations · Cited by this paper
  6. Functional interactions of Kv1.3 channels in microglia and T cells and their implications in neurodegeneration · 2026 · Related
  7. Use of directed acyclic graphs (DAGs) to identify confounders in applied health research: review and recommendations · Peter W. G. Tennant · 2020 · 1066 citations · Cited by this paper
  8. A critical look at disease classification/diagnosis criteria in rheumatology · 2026 · Related
  9. Efficacy and safety of tofacitinib monotherapy, tofacitinib with methotrexate, and adalimumab with methotrexate in patients with rheumatoid arthritis (ORAL Strategy): a phase 3b/4, double-blind, head-to-head, randomised controlled trial · Roy Fleischmann · 2017 · 505 citations · Cited by this paper
  10. Mapping antibody sequences and effector functions across spatial niches · 2026 · Related
  11. Transparent Reporting of Observational Studies Emulating a Target Trial—The TARGET Statement · Aidan Gregory Cashin · 2025 · 235 citations · Cited by this paper
  12. Why we need to maintain a critical view on big data and artificial intelligence predictions · 2026 · Related
  13. Core concepts in pharmacoepidemiology: Confounding by indication and the role of active comparators · Rachel Sendor · 2022 · 198 citations · Cited by this paper
  14. From disease to syndrome: the evolution of Parkinson’s as a heterogeneous entity · 2026 · Related
  15. An International registry on Autoinflammatory diseases: the Eurofever experience · Nataša Toplak · 2012 · 194 citations · Cited by this paper
  16. Recurrent pericarditis in children: evidence, controversies, and emerging perspectives · 2026 · Related
  17. The Target Trial Framework for Causal Inference From Observational Data: Why and When Is It Helpful? · Miguel Ángel Hernán · 2025 · 188 citations · Cited by this paper
  18. Spatial metabolic heterogeneity shapes CD8+ T cell function in cancer · 2026 · Related
  19. Target Trial Emulation to Improve Causal Inference from Observational Data: What, Why, and How? · Edouard L. Fu · 2023 · 180 citations · Cited by this paper
  20. Leveraging the PEDSnet clinical research network and electronic health record data to enhance efficiency of trial enrollment for a rare pediatric rheumatic disease · 2026 · Related
  21. Networking in paediatrics: the example of the Paediatric Rheumatology International Trials Organisation (PRINTO) · Nicolino Ruperto · 2011 · 175 citations · Cited by this paper
  22. Reporting of Observational Studies Explicitly Aiming to Emulate Randomized Trials · Harrison J Hansford · 2023 · 101 citations · Cited by this paper
  23. A Structural Description of Biases That Generate Immortal Time · Miguel Ángel Hernán · 2024 · 92 citations · Cited by this paper
  24. Philosophy of Inferences from Retrospective Studies · Harold F. Dorn · 1953 · 63 citations · Cited by this paper
  25. Process guide for inferential studies using healthcare data from routine clinical practice to evaluate causal effects of drugs (PRINCIPLED): considerations from the FDA Sentinel Innovation Center · Rishi J. Desai · 2024 · 61 citations · Cited by this paper
  26. Pediatric Rheumatology Collaborative Study Group – over four decades of pivotal clinical drug research in pediatric rheumatology · Hermine I. Brunner · 2018 · 49 citations · Cited by this paper
  27. Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee · Gabriella Giancane · 2020 · 41 citations · Cited by this paper
  28. Causal inference in survival analysis using longitudinal observational data: Sequential trials and marginal structural models · Ruth H. Keogh · 2023 · 39 citations · Cited by this paper
  29. A survey of national and multi-national registries and cohort studies in juvenile idiopathic arthritis: challenges and opportunities · Timothy Beukelman · 2017 · 37 citations · Cited by this paper
  30. Comparative Risks of Infection With Belimumab Versus Oral Immunosuppressants in Patients With Nonrenal Systemic Lupus Erythematosus · Emma Materne · 2023 · 31 citations · Cited by this paper
  31. Are Target Trial Emulations the Gold Standard for Observational Studies? · Neil Pearce · 2023 · 30 citations · Cited by this paper
  32. Early Initiation of Biologics and Disease Outcomes in Adults and Children With Inflammatory Bowel Diseases: Results From the Epidemiology Group of the Nationwide Israeli Inflammatory Bowel Disease Research Nucleus Cohort · Rona Lujan · 2024 · 27 citations · Cited by this paper
  33. Starting right: aligning eligibility and treatment assignment at time zero when emulating a target trial · Edouard L Fu · 2026 · 27 citations · Cited by this paper
  34. Efficacy and Safety of Sodium–Glucose Cotransporter 2 Inhibitors for the Primary Prevention of Cardiovascular, Renal Events, and Safety Outcomes in Patients With Systemic Lupus Erythematosus and Comorbid Type 2 Diabetes: A Population‐Based Target Trial Emulation · Kevin Sheng‐Kai · 2024 · 26 citations · Cited by this paper
  35. Improving rheumatoid arthritis comparative effectiveness research through causal inference principles: systematic review using a target trial emulation framework · Sizheng Steven Zhao · 2020 · 24 citations · Cited by this paper
  36. Advancing Principled Pharmacoepidemiologic Research to Support Regulatory and Healthcare Decision Making: The Era of Real‐World Evidence · Rohini K. Hernandez · 2025 · 17 citations · Cited by this paper
  37. Effect of first-line biologic initiation on glucocorticoid exposure in children hospitalized with new-onset systemic juvenile idiopathic arthritis: emulation of a pragmatic trial using observational data · Rosemary G. Peterson · 2021 · 16 citations · Cited by this paper
  38. Conducting observational analyses with the target trial emulation approach: a methodological systematic review · Noémie Simon‐Tillaux · 2024 · 14 citations · Cited by this paper
  39. Non-TNFi biologic and targeted synthetic DMARDs in rheumatoid arthritis-associated interstitial lung disease: A propensity score-matched, active-comparator, new-user study · Halie Frideres · 2025 · 13 citations · Cited by this paper

Source: OpenAlex (CC0)